Histological study of the internal mammary artery with emphasis on its suitability as a coronary artery bypass graft

Son, Jacques A.M. van; Smedts, Frank; Wilde, P.C.M. de; Pijls, Nico H.J.; Wong-Alcala, Luthy S M; Kubat, K; Tavilla, Giuseppe; Lk, Lacquet

doi:10.1016/0003-4975(93)90483-x

Cited by 89 publications

(35 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The internal mammary artery is the only medium-sized artery to possess an elastic component like that of elastic arteries, in addition to typical muscular features. 23 This complex nature may have its origin in embryological development, as the internal mammary artery forms from anastomoses of thoracic intersegmental arteries that develop directly from the dorsal aorta. 29 Apart from the medial SMCs, zones of intimal thickening were also identified occasionally, and the SMCs in these zones more closely resemble those of the elastic medial regions than those of the muscular medial regions with respect to patterns of Cx43 and desmin expression.…”

Section: Discussionmentioning

confidence: 99%

“…The internal mammary artery is relatively resistant to atherosclerosis, and is the preferred choice of vessel for coronary artery bypass surgery, 22 but our knowledge of the cellular basis of these properties has so far remained limited. The primary reason for selecting this vessel for study is that, in its distal region, it has an unusual histological pattern, ranging from elastic to elastomuscular to muscular, 23 with SMCs of correspondingly distinctive morphology and intermediate filament expression patterns, 24 thus providing an opportunity to compare the relationship between Cx43 expression and SMC heterogeneity within a single vessel. By characterizing the SMCs with respect to histological location, ultrastructural morphology, connexin expression (by immunohistochemistry and in situ hybridization), and differentiation marker expression (by immunohistochemistry), we show that Cx43 expression is high and desmin expression low in SMCs of elastic medial regions, whereas the converse characteristics apply to SMCs of muscular medial regions.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Differential Expression of Connexin43 and Desmin Defines Two Subpopulations of Medial Smooth Muscle Cells in the Human Internal Mammary Artery

Yeh

Haw

et al. 1999

ATVB

View full text Add to dashboard Cite

Abstract-Upregulation of connexin43-gap junctions is associated with transition of contractile vascular smooth muscle cells (SMCs) to the synthetic state. To determine whether phenotypically distinct subpopulations of medial SMCs differentially express connexin43, we investigated the human distal internal mammary artery, a structurally heterogeneous vessel with features ranging from elastic to elastomuscular to muscular. Immunoconfocal microscopy combined with quantitative analysis and complemented by in situ hybridization showed that SMCs in the elastic medial regions expressed high levels of connexin43 but low levels of desmin, whereas those of muscular medial regions expressed low levels of connexin43 but high levels of desmin. Ultrastructurally, SMCs of both regions were of the contractile phenotype, but the former cells were irregular in shape with relatively prominent synthetic organelles whereas the latter were spindle shaped with fewer synthetic organelles. Vimentin, smooth muscle ␣-actin, calponin, h-caldesmon, and myosin heavy chains (SM1 and SM2) were equally highly expressed by most cells in both subpopulations. The connexin43/desmin expression pattern of SMCs in regions of intimal thickening resembled those of elastic medial regions. These findings refine the view suggested from previous studies that high levels of connexin43 expression are associated with SMCs of a less contractile/more synthetic phenotype. In the internal mammary artery, the 2 subpopulations of SMCs with markedly different connexin43 expression levels both represent a differentiated contractile phenotype, but the subpopulation showing high levels of connexin43-gap junctions is characterized by low levels of desmin and structural features that reflect a more synthetic tendency.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Differential Expression of Connexin43 and Desmin Defines Two Subpopulations of Medial Smooth Muscle Cells in the Human Internal Mammary Artery

Yeh

Haw

et al. 1999

ATVB

View full text Add to dashboard Cite

show abstract

“…Van Son et al studied the histology compared to other arterial grafts used in CABG and reported that the ITA presents with a uniform structure along its length [9]. In a future study, correcting this first study, the authors demonstrated the variability of the histologic composition of the ITA over its different segments [6]. This study confirmed that there is a greater predominance of elastic fibers in the medial segment of the ITA than in the proximal and distal segments.…”

Section: Discussionmentioning

confidence: 55%

“…Additionally, the relative immunity of the LITA to arteriosclerosis greatly contributes to this [3,4] as do specific factors of the vessel wall such as the histologic [5,6], ultrastructural [5] and histochemical [7,8] compositions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<![CDATA[<B>Sequential histomorphometric study of the left internal thoracic artery</B>]]>

Kneubil¹,

Gomes²,

Aquino³

et al. 2006

Braz. j. cardiovasc. surg.

View full text Add to dashboard Cite

Objective: The use of left internal thoracic artery (LITA) in coronary artery bypass surgery is currently recognized as the best option, providing lower incidences of cardiovascular events and superior long-term survival. Now, incremental utilization of these grafts makes a reassessment of its histological structure necessary. Therefore, the purpose of this study was to examine and compare the sequential histological structure of LITA.Method: Specimens of LITA harvested from 18 cadavers, divided into nine proportional segments, were studied. Cuts of each segment were stained by the Verhoeff-Van Gieson technique. The following parameters were analyzed: perimeter of the arterial lumen, thickness of the intima, thickness of the media layer, amount of elastic fiber in the media layer and the elastic fiber density.Results: The collected data showed that perimeter of the LITA decreases downstream on its course, the thickness of the intima is increased in the proximal segments, the thickness of the media layer diminishes throughout its extension, the number of elastic fibers is concentrated in the intermediate segments and the density of elastic fibers is reduced in the proximal and distal segments. Conclusion:Therefore, the findings of the present study validate the heterogeneity of the LITA sequential histological structure. Descriptors

show abstract

Elective stenting of a de novo ostial lesion of the right internal mammary artery

Bedogni

Vecchia

1998

Cathet. Cardiovasc. Diagn.

View full text Add to dashboard Cite

Histological study of the internal mammary artery with emphasis on its suitability as a coronary artery bypass graft

Cited by 89 publications

References 30 publications

Differential Expression of Connexin43 and Desmin Defines Two Subpopulations of Medial Smooth Muscle Cells in the Human Internal Mammary Artery

Differential Expression of Connexin43 and Desmin Defines Two Subpopulations of Medial Smooth Muscle Cells in the Human Internal Mammary Artery

<![CDATA[<B>Sequential histomorphometric study of the left internal thoracic artery</B>]]>

Elective stenting of a de novo ostial lesion of the right internal mammary artery

Contact Info

Product

Resources

About