Histological validation of ultrasound‐guided neurography in early nerve regeneration

Neck, Johan W. van; Kool, Bridget; Hekking‐Weijma, J. M.; Walbeehm, Erik T.; Visser, Gerhard H.; Blok, Joleen H.

doi:10.1002/mus.21405

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Although not standard, near-nerve needle recording and stimulation have been performed for decades [115] and given the increased need for sensitive measures from non-standard nerves in the context of neuroregeneration studies, their improved validity in this context is likely relevant to many studies involving neuroregeneration. The CNAP is a fundamental biomarker of nerve health that can be recorded using needle electrodes with guidance from stimulation, direct visualization, or more recently ultrasound [19,115,[200][201][202]. Reference values for amplitudes are not currently available because of increased variability as the amount and type of tissue, and therefore resistance, between electrode and nerve reduces [115,203].…”

Section: Needle Stimulation and Recordingmentioning

confidence: 99%

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology

et al. 2023

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Peripheral neuroregeneration research and therapeutic options are expanding exponentially. With this expansion comes an increasing need to reliably evaluate and quantify nerve health. Valid and responsive measures that can serve as biomarkers of the nerve status are essential for both clinical and research purposes for diagnosis, longitudinal follow-up, and monitoring the impact of any intervention. Furthermore, such biomarkers can elucidate regeneration mechanisms and open new avenues for research. Without these measures, clinical decision-making falls short, and research becomes more costly, time-consuming, and sometimes infeasible. As a companion to Part 2, which is focused on non-invasive imaging, Part 1 of this two-part scoping review systematically identifies and critically examines many current and emerging neurophysiological techniques that have the potential to evaluate peripheral nerve health, particularly from the perspective of regenerative therapies and research.

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Section: Needle Stimulation and Recordingmentioning

confidence: 99%

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology

et al. 2023

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Reference values for nerve ultrasonography in the upper extremity

et al. 2013

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Anodal Block in Evaluation of Nerve Conduction Changes in Anesthetized Rats: Preclinical Non-Randomized Experimental Study

Pokrovskii

Ardelyan

Tashu

et al. 2022

Kuban. nauсh. med. vestnik

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Background. There is currently no gold standard for functional assessment of nerve regeneration. Different researchers use various methods to assess the functionality of the regenerated nerve directly and indirectly. Indirect methods have the advantage of being minimally invasive, and the benefit of direct methods is recording the signal directly in the nerve.Objectives. To identify significant parameters of neurogram changes in the sciatic nerve in an anaesthetized rat when the anode block is applied and to evaluate neurography as a method for functional assessment of nerve regeneration.Methods. A series of experiments was performed on 10 anaesthetized rats. A DC anode was placed on the exposed sciatic nerve, more proximal and more distal to the recording electrodes, and a common cathode in the form of a needle was introduced into one of the forelimbs. Needle nichrome electrodes were introduced into the nerve using a manipulator. An original neurogram and a neurogram against anode activation were recorded by closing the DC circuit of different voltages to block the afferent signal, efferent signal and afferent and efferent signals simultaneously.Results. When the anodal block of different voltages was applied to the afferent signal, efferent signal, and afferent and efferent signals simultaneously in all 10 experiments, the frequency-amplitude characteristics of the neurogram changed significantly as compared to the original neurogram. The amplitude of the neurogram increased considerably, while the frequency decreased, though not so dramatically. The changes in amplitude and frequency parameters were revealed to depend on the voltage value. In most cases, this relationship was directly proportional to the amplitude and inversely proportional to the frequency.Conclusion. Considering the nature of the dynamics of the neurogram when exposed to the anodal block, the most significant parameter of its change is the amplitude. Changes in nerve fibre composition during its regeneration after damage cause changes in afferent and efferent signals, which is likely to be displayed in the neurogram as compared to the initial state. Thus, the anodal block can be used as a model of nerve damage, and the analysis of the dynamics of neurogram parameters — as a method for functional assessment of nerve regeneration.

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Histological validation of ultrasound‐guided neurography in early nerve regeneration

Cited by 4 publications

References 31 publications

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology

Reference values for nerve ultrasonography in the upper extremity

Anodal Block in Evaluation of Nerve Conduction Changes in Anesthetized Rats: Preclinical Non-Randomized Experimental Study

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