Histologically confirmed nonbacterial thrombotic endocarditis in a febrile leukemic patient

Jeong, Eun Gyo; Jung, Mi‐Hyang; Youn, Ho-Joong

doi:10.3904/kjim.2016.135

Cited by 6 publications

(3 citation statements)

References 3 publications

(3 reference statements)

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“…Most of these patients were diagnosed by pathological autopsy [3]. A previous study reported that in the past, one patient with newly diagnosed APL developed NTBE [9]. Due to clinically suspected IE, antibiotics were first administered.…”

Section: Discussionmentioning

confidence: 99%

“…In some cases where surgery was performed for NTBE, the prognosis was good [8]. Moreover, in the previously reported cases of NTBE associated with APL, surgical treatment was followed by combination therapy with all-trans retinoic acid (ATRA) and arsenic trioxide, and the general condition improved [9]. Anticoagulation therapy is relatively contraindicated in cases of DIC complicated by APL, therefore, immediate treatment with ATRA is recommended [11,12].…”

Section: Discussionmentioning

confidence: 99%

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Nonbacterial Thrombotic Endocarditis Associated with Acute Promyelocytic Leukemia: An Autopsy Case Report

Hashimoto

Aoki

Kawabata³

et al. 2021

Medicina

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Valve vegetation is one of the most fearful findings for physicians. The first diagnosis that comes to their mind is infective endocarditis (IE), but it can also be noninfective; nonbacterial thrombotic endocarditis (NBTE). NBTE can be even more challenging than IE for physicians because of the wide range of differential diagnoses such as malignancies, autoimmune disorders and human immunodeficiency virus. A 45-year-old woman presented at the emergency room with a sudden onset of dysarthria and right-sided hemiplegia. Laboratory data showed her blood counts and coagulation test were mostly normal and the magnetic resonance imaging detected a high-signal-intensity change in her left brain. An echocardiogram found a vegetation-like structure on her atrial valve. We highly suspected IE leading to cerebral embolism. The clot was successfully removed by our neurosurgeons and anticoagulation therapy was started concurrently. Her state of consciousness improved, but then she suffered a brain hemorrhage and died. The autopsy revealed that the cause of her vegetation was acute promyelocytic leukemia (APL). Based on these findings, it is important to remember that APL can be the cause of NBTE even if the blood count and coagulation tests are almost normal.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis Associated with Acute Promyelocytic Leukemia: An Autopsy Case Report

Hashimoto

Aoki

Kawabata³

et al. 2021

Medicina

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“…There have been various reports of infective endocarditis (IE) in patients with ALL and AML. Nevertheless, cases of nonbacterial thrombotic endocarditis (NBTE), or marantic endocarditis, are few by report in AML, and extremely rare in ALL [9]. They are associated with several other hematologic conditions, such as hypercoagulable states which can be seen with various forms of malignancy [10].…”

Section: Discussionmentioning

confidence: 99%

Geriatric Presentation of Hyperleukocytosis in Setting of B-Cell Acute Lymphoblastic Leukemia, Border-Zone Ischemic Stroke and Endocarditis

Cajavilca¹,

Lam²,

Sykes³

et al. 2019

Int J Blood Res Disord

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BackgroundAcute lymphoblastic leukemia (ALL) is an unusual diagnosis in the adult population. They represent 20% of the cases in the adult population. Moreover, acute leukemia in the elderly is rarely reported in combination with ischemic stroke. We present a case of a female patient presenting with acute hyperleukocytosis and new diagnosis of ALL, border-zone ischemic infarcts, and nonbacterial thrombotic endocarditis. Case PresentationAn 81-year-old female with past medical history significant for stable congestive heart failure, atrial fibrillation on apixaban, and coronary artery disease presented to an outside hospital with 12-hour history of

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Neurologic complications of nonbacterial thrombotic endocarditis

Dafer

2021

Handbook of Clinical Neurology

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Histologically confirmed nonbacterial thrombotic endocarditis in a febrile leukemic patient

Cited by 6 publications

References 3 publications

Nonbacterial Thrombotic Endocarditis Associated with Acute Promyelocytic Leukemia: An Autopsy Case Report

Nonbacterial Thrombotic Endocarditis Associated with Acute Promyelocytic Leukemia: An Autopsy Case Report

Geriatric Presentation of Hyperleukocytosis in Setting of B-Cell Acute Lymphoblastic Leukemia, Border-Zone Ischemic Stroke and Endocarditis

Neurologic complications of nonbacterial thrombotic endocarditis

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