Histologisch-histochemische und immunhistochemische Untersuchungen an Knorpelkanälen menschlicher Rippenknorpel

Craatz, Steffen; Weiss, J.; Schmidt, Wolfgang

doi:10.1016/s0940-9602(99)80128-9

Cited by 6 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During our study, we detected these cartilage canals particularly in the central parts of the cartilage. These findings confirm the nutritive function of canals as previously noted in many studies [21,50]. In accordance with the results from Kampen et al's study [15], we proved that central parts of costal cartilages ossify later.…”

Section: Discussionsupporting

confidence: 93%

“…However, our study did not prove either of these assumptions. It confirmed the vascularization of costal cartilages in agreement with other authors [20,21]. We found that the cartilage of newborns and small children is densely penetrated with cartilage canals.…”

Section: Discussionsupporting

confidence: 93%

“…It is supplied from the surrounding vascular network by perichondral diffusion [19]. However, the vascularization of the hyaline cartilage has been described both in the prenatal and in the postnatal period [20][21][22][23]. Muss has even described two periods of costal cartilage vascularization [24].…”

mentioning

confidence: 99%

“…The exact role of these canals remains controversial. In addition to their nutritive function and participation in the metabolism of the cartilage [21], an osteogenic function is also being investigated [22,23,25]. The development of cartilage canals occurs first during epiphyseal ossification in mammals.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Age and sexually dimorphic changes in costal cartilages. A preliminary microscopic study

Rejtarová

Hejna

Soukup

et al. 2009

Forensic Science International

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Age and sexually dimorphic changes in costal cartilages. A preliminary microscopic study

Rejtarová

Hejna

Soukup

et al. 2009

Forensic Science International

View full text Add to dashboard Cite

“…Cartilage canals (also known as vascular canals: VCs) are vascularized tubular structures present in the epiphyseal cartilage of bones and are involved in the formation of secondary ossification centers via endochondral ossification in mammals, birds, and reptiles (Blumer et al, ). Cartilage canals also are present in human bone (Chandraraj and Briggs, ; Craatz et al, ; Gilbert et al, ; Fritsch et al, ), thyroid cartilage (Claassen et al, ), and mandibular condylar cartilage (Blackwood, ; Thilander et al, ; Takenoshita, ; Morimoto et al, ; Linss and Möller, ; Mérida‐Velasco et al, ; Rusu et al, ). The term of VCs rather than cartilage canals has traditionally been used in mandibular condylar cartilage.…”

mentioning

confidence: 99%

An Immunohistochemical Study of Matrix Components in Early‐Stage Vascular Canals Within Mandibular Condylar Cartilage in Midterm Human Fetuses

Shibata

Morita

Yokohama-Tamaki

et al. 2015

The Anatomical Record

View full text Add to dashboard Cite

Matrix components of vascular canals (VCs) in human fetal mandibular condylar cartilage (15-16 weeks of gestation) were analyzed by immunohistochemistry. Prevascular canals (PVCs), consisting of spindle-shaped cells without capillary invasion, were observed within the cartilage. Intense immunoreactivity for collagen type I, weak immunoreactivity for aggrecan and tenascin-C, weak hyaluronan (HA) staining, and abundant argyrophilic fibers in PVCs indicated that they contain noncartilaginous fibrous connective tissues that was different from those in the perichondrium/periosteum. These structural and immunohistochemical features of PVCs are different from those of previously reported cartilage canals of the long bone. Capillaries entered the VCs from the periosteum and ascended through VCs. Following capillary invasion, loose connective tissue had formed in the lower part of VCs, and immunoreactivity for collagen types I and III, tenascin-C, and HA staining was evident in the matrix of loose connective tissue. No chondroclasts or osteogenic cells were seen at the front of capillary invasion, although small, mononuclear tartrate-resistant acid phosphatase (TRAP)-positive cells were present. Meanwhile, TRAP-positive, multinucleated chondroclasts and flattened, osteoblast-like cells were observed in the loose connective tissue at the lower part of VCs. These results may indicate slow progress of endochondral ossification in human fetal mandibular condyle. Further, unique matrix components in PVCs/VCs, which were different from those in cartilage canals in long bone, may reflect the difference of speed of endochondral ossification in cartilage canals and human fetal mandibular condyles. Anat Rec, 298:1560Rec, 298: -1571Rec, 298: , 2015

show abstract

Vascular Canals in Permanent Hyaline Cartilage: Development, Corrosion of Nonmineralized Cartilage Matrix, and Removal of Matrix Degradation Products

Gabner

Häusler

Böck

2017

The Anatomical Record

View full text Add to dashboard Cite

Core areas in voluminous pieces of permanent cartilage are metabolically supplied via vascular canals (VCs). We studied cartilage corrosion and removal of matrix degradation products during the development of VCs in nose and rib cartilage of piglets. Conventional staining methods were used for glycosaminoglycans, immunohistochemistry was performed to demonstrate collagens types I and II, laminin, Ki-67, von Willebrand factor, VEGF, macrophage marker MAC387, S-100 protein, MMPs -2,-9,-13,-14, and their inhibitors TIMP1 and TIMP2. VCs derived from connective tissue buds that bulged into cartilage matrix ("perichondrial papillae", PPs). Matrix was corroded at the tips of PPs or resulting VCs. Connective tissue stromata in PPs and VCs comprised an axial afferent blood vessel, peripherally located wide capillaries, fibroblasts, newly synthesized matrix, and residues of corroded cartilage matrix (collagen type II, acidic proteoglycans). Multinucleated chondroclasts were absent, and monocytes/macrophages were not seen outside the blood vessels. Vanishing acidity characterized areas of extracellular matrix degradation ("preresorptive layers"), from where the dismantled matrix components diffused out. Leached-out material stained in an identical manner to intact cartilage matrix. It was detected in the stroma and inside capillaries and associated downstream veins. We conclude that the delicate VCs are excavated by endothelial sprouts and fibroblasts, whilst chondroclasts are specialized to remove high volumes of mineralized cartilage. VCs leading into permanent cartilage can be formed by corrosion or inclusion, but most VCs comprise segments that have developed in either of these ways. Anat Rec, 300:1067-1082, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

Histologisch-histochemische und immunhistochemische Untersuchungen an Knorpelkanälen menschlicher Rippenknorpel

Cited by 6 publications

References 5 publications

Age and sexually dimorphic changes in costal cartilages. A preliminary microscopic study

Age and sexually dimorphic changes in costal cartilages. A preliminary microscopic study

An Immunohistochemical Study of Matrix Components in Early‐Stage Vascular Canals Within Mandibular Condylar Cartilage in Midterm Human Fetuses

Vascular Canals in Permanent Hyaline Cartilage: Development, Corrosion of Nonmineralized Cartilage Matrix, and Removal of Matrix Degradation Products

Contact Info

Product

Resources

About