Histologische untersuchungen des lymphatischen Gewebes beim pl�tzlichen Kindstod

Entrup, Maria; Brinkmann, B.

doi:10.1007/bf00204706

Cited by 1 publication

(4 citation statements)

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“…In accordance with the previous study [2] and the results of others [3,4,5] a substantial lack of reactivity in the immune system of SID victims could not be demonstrated. The B-and T-cell antigens investigated showed normal reactivity and a correlation with the histological classifications.…”

Section: Discussionsupporting

confidence: 89%

“…These features increased from group A to C while T-cell antigens showed normal expressions. VHP and SH seem to be especially associated with virus infection [2]. FH could be found in all nl regions investigated as a "generalized" feature while PLH and VHP if present were more often and more strongly expressed in the lung hilum.…”

Section: Discussionmentioning

confidence: 97%

“…Lymph node (nl) changes were classified as follows [2,12,13]. If combination patterns between the defined reaction patterns were observed, the most prominent one was chosen for classification.…”

Section: Histologymentioning

confidence: 99%

“…Correlations to the various reaction pattern of the lymphatic tissues [2] showed that 77% of cases with pulmonary inflammation had different varieties of the florid type of reaction compared to only 17% of control cases. Immunological and histological investigations carried out in SID cases [3,4,5] gave no evidence for disturbances of the humoral immunsystem in these infants.…”

Section: Introductionmentioning

confidence: 96%

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Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)

Bajanowski

Ortmann

Hernández

et al. 1997

International Journal of Legal Medicine

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In 50 cases of sudden infant death cervical, paratracheal and lung hilar lymph nodes, the thymus and the spleen were investigated by histology and immunohistochemistry (CD 20, 21, 45RO). The cases were divided into 3 groups based on autopsy findings including extensive histology: A --without pathological changes (N = 12), B --with minimal to intermediate inflammation (N = 23) and C --with severe inflammation (N = 15). In accordance with previous results the frequency of "pathological" lymph node changes, such as paracortical lymphoid hyperplasia and variegated hyperplasia of the pulp increased from group A to group C. The B-cell antigens reacted accordingly. A pronounced lymphodepletation of the thymus as a sign of a long lasting stimulation of the T-cell system was also observed increasingly from group A to C. In summary, in none of the cases results obtained were indicative of a defect of the T- or B-cell system. The results in group A seem to indicate that changes in the reaction pattern of the lymphoid tissues could be a more sensitive method of detection of early stages of inflammation than local histology.

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