Histology of Epithelial Skin Tumors

Reichrath, Jörg; Querings, Kerstin

doi:10.1007/0-387-35098-5_2

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Historically, the association between solar UV‐exposure and non‐melanoma skin cancer was first reported by Unna and Dubreuilh at the end of the 19th century 21,22 . These physicians recognized actinic keratoses (AK) and squamous cell carcinomas (SCC) in chronically sun‐exposed skin areas of sailors and vineyard workers (notably, AK are now considered to represent cutaneous SCC in situ ) 23 . At present, it is scientifically accepted that solar UV‐exposure represents the most important environmental risk factor for the development of AK, SCC and basal cell carcinomas (BCC) 24–29 .…”

Section: Uv‐b‐radiation – a Double‐edged Swordmentioning

confidence: 99%

“…cell carcinomas (SCC) in chronically sun-exposed skin areas of sailors and vineyard workers (notably, AK are now considered to represent cutaneous SCC in situ). 23 At present, it is scientifically accepted that solar UV-exposure represents the most important environmental risk factor for the development of AK, SCC and basal cell carcinomas (BCC). [24][25][26][27][28][29] Epidemiological and laboratory data have convincingly shown that sunburns are implicated in the pathogenesis of SCC, 30 BCC, 25,31 and MM.…”

Section: Photocarcinogenesismentioning

confidence: 99%

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Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?

Reichrath

2009

British Journal of Dermatology

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Because solar UV-radiation represents the most important environmental risk factor for the development of non-melanoma skin cancer, UV protection is important to prevent these malignancies. Consequently, public health campaigns were developed to improve the knowledge of the general population regarding the role of UV-radiation for the development of skin cancer. However, it has to be noted that vitamin D-mediated positive effects of UV light were not adequately considered in most of these campaigns, that often propose a strict 'no sun policy' without giving recommendations how to prevent vitamin D-deficiency. Under our living conditions, approximately 90% of all vitamin D needed by the human body has to be formed in the skin through the action of UV-B-radiation and it has been shown that strict sun protection causes vitamin D-deficiency. This dilemma represents a serious problem, for an association of vitamin D-deficiency and multiple independent diseases including various types of cancer, bone diseases, autoimmune diseases, infectious diseases, cardiovascular diseases and hypertension has now been reported in a large number of laboratory and epidemiologic investigations. Although further work is necessary to define an adequate vitamin D-status and adequate guidelines for UV-exposure, it is at present mandatory that guidelines for UV-exposure (e.g. in skin cancer prevention campaigns) consider these facts and give recommendations how to prevent vitamin D-deficiency. At present, most experts in the field agree that the evidence to date suggests that daily intake of 1000-2000 IU vitamin D could reduce the incidence of vitamin D-deficiency-related diseases with minimal risk in Europe, the US, and other countries. In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status. These recommendations will hopefully protect us against vitamin D-deficiency without increasing the risk to develop UV-induced skin cancer.

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Section: Uv‐b‐radiation – a Double‐edged Swordmentioning

confidence: 99%

Section: Photocarcinogenesismentioning

confidence: 99%

Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?

Reichrath

2009

British Journal of Dermatology

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“…It is, however, far more aggressive than BCC 8 . Immunosuppression, smoking, carcinogenic chemicals, preexisting lesions, and occupational hazards are among the predisposing factors 9,10 . Neglected SCC represents an excellent milieu for myiasis, and larvae thrive in large, ulcerated, and necrotic tumors, with consequent bleeding, infection, and pain 11 resulting in significant morbidity and aggravation of an already debilitated host.…”

Section: Introductionmentioning

confidence: 99%

Myiasis in Neglected Cutaneous Squamous Cell Carcinoma of the Head and Neck: Review of Management and Current Protocol Recommendations

Grinblat

Frenkel

Shochat

et al. 2021

Adv Skin Wound Care

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OBJECTIVE To propose a first-aid management protocol for myiasis in neglected cutaneous squamous cell carcinoma (SCC) in the ED based on a recent literature review. DATA SOURCES PubMed. STUDY SELECTION Inclusion criteria were all series and case reports of primary/secondary cutaneous SCC with myiasis of the head and neck, including orbital SCC cases, published after 2005. DATA EXTRACTION A total of 14 articles including 15 patients were included. DATA SYNTHESIS Demographics, socioeconomic situation, site of the lesion, larvae species with bacterial suprainfection, and first-aid treatment options were discussed. Two representative cases are described. CONCLUSIONS Large, ulcerated, necrotic, myiasis-burdened SCC lesions in the head and neck area present a challenge for treatment, and to date, no consensus regarding first-aid management exists. The authors’ proposed four-pillar first-aid management scheme may be a valid option to rapidly improve wound condition through disinfection, pain relief, and malodor and discharge eradication as a bridge to surgery.

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Sunlight, Skin Cancer, and Vitamin D

Reichrath

2010

Vitamin D

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Histology of Epithelial Skin Tumors

Cited by 4 publications

References 29 publications

Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?

Skin cancer prevention and UV-protection: how to avoid vitamin D-deficiency?

Myiasis in Neglected Cutaneous Squamous Cell Carcinoma of the Head and Neck: Review of Management and Current Protocol Recommendations

Sunlight, Skin Cancer, and Vitamin D

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