Histology of Laryngeal Mucosa

Štiblar-Martinčič, Draga

doi:10.3109/00016489709124057

Cited by 27 publications

(18 citation statements)

References 15 publications

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“…Within the larynx, SSE is unique to the membranous vocal folds and the superficial surface of the epiglottis (Stell, Gudrun, & Watt, 1981). SSE of the vocal folds transitions to a ciliated pseudostratified columnar epithelium at the anterior and posterior commissures, supraglottis, and subglottis (Bulmer, Ali, Brownlee, Dettmar, & Pearson, 2010; Fisher, et al, 2001; Gray, 2000; Stiblar-Martincic, 1997). Epithelium lining the upper airway is also designated as ciliated pseudostratified columnar which is composed of numerous cell types including ciliated columnar cells and mucus-secreting goblet cells (Knight & Holgate, 2003).…”

Section: Structure Of the Vocal Fold Epithelial Barriermentioning

confidence: 99%

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Levendoski

Leydon

Thibeault

2014

J Speech Lang Hear Res

116

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Purpose Vocal fold epithelium is composed of layers of individual epithelial cells joined by junctional complexes constituting a unique interface with the external environment. This barrier provides structural stability to the vocal folds and protects underlying connective tissue from injury while being nearly continuously exposed to potentially hazardous insults including environmental or systemic-based irritants such as pollutants and reflux, surgical procedures, and vibratory trauma. Small disruptions in the epithelial barrier may have a large impact on susceptibility to injury and overall vocal health. The purpose of this article is to provide a broad-based review of our current knowledge of the vocal fold epithelial barrier. Methods A comprehensive review of the literature was conducted. Details of the structure of the vocal fold epithelial barrier are presented and evaluated in the context of function in injury and pathology. The importance of the epithelial-associated vocal fold mucus barrier is also introduced. Results/Conclusions Information presented in this review is valuable for clinicians and researchers as it highlights the importance of this understudied portion of the vocal folds to overall vocal health and disease. Prevention and treatment of injury to the epithelial barrier is a significant area awaiting further investigation.

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Section: Structure Of the Vocal Fold Epithelial Barriermentioning

confidence: 99%

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Levendoski

Leydon

Thibeault

2014

J Speech Lang Hear Res

116

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“…31 Inflammatory and irritant stimuli can cause a transient or a long-lasting laryngeal narrowing; that is the laryngeal hyperresponsiveness, which contributes to stridor, transmitted wheezing and breathlessness. In addition, antigen-handling cells can be found in the laryngeal mucosa, 33 which suggests that allergens may be important in the development of laryngeal hyper-responsiveness. 31 Vocal cord dysfunction an altered state of autonomic balance, maintained by the activity of more central brain regions as the underlying pathogenesis for PVCM.…”

Section: Pathogenesis Of Pvcmmentioning

confidence: 99%

Paradoxical vocal cord motion disorder: past, present and future

Ibrahim

Gheriani

Almohamed

et al. 2007

Postgraduate Medical Journal

114

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Paradoxical vocal cord motion disorder (PVCM), also called vocal cord dysfunction, is an important differential diagnosis for asthma. The disorder is often misdiagnosed as asthma leading to unnecessary drug use, very high medical utilisation and occasionally tracheal intubation or tracheostomy. Laryngoscopy is the gold standard for diagnosis of PVCM. Speech therapy and psychotherapy are considered the cornerstone of management of this disorder. The aim of this article is to increase the awareness of PVCM among doctors, highlighting the main characteristics that distinguish it from asthma and discuss the recent medical achievements and the possible future perspectives related to this disorder.

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“…Os epitélios do tipo escamoso estratificado são formados mitoticamente a partir das células mais basais que são levadas, pela proliferação contínua, em direção a superfície do epitélio. Neste processo, modifica seu formato de colunar ou cubóide para pavimentoso 9 . Da superfície, a cé-lula é removida por abrasão.…”

Section: Discussionunclassified

Células de Langerhans no epitélio da prega vocal humana: estudo imunoistoquímico

Filho

Ferreira

Filho

et al. 2004

Rev. Bras. Otorrinolaringol.

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Cél ulas de Langerhans (CL) são um tipo de células dendríticas que têm funções que envolvem apresentação de antígeno e a estimulação de resposta T dependente. Elas representam aproximadamente 4% das células do epitélio laríngeo. Objetivo: Identificar a presença de CL no epitélio das pregas vocais, comparar suas subpopulações, bem com comparar a capacidade de quatro marcadores imunoistoquímicos. Forma de Estudo: Experimental. Casuística e Método: Seis cadáveres, 3 homens e 3 mulheres foram estudados. Foram analisadas amostras de pele e das pregas vocais coradas e imunomarcadas para vimentina, proteína S-100, CD-68 e fascina. Após análise histológica, foi realizado o teste t de Student e análise de variância no estudo estatístico. Resultados e Conclusões: Foi possível identificar a presença de CL no epitélio das pregas vocais de humanos não fumantes de ambos os sexos. A fascina, a vimentina o CD-68 mostraram-se bons marcadores das CL, enquanto a proteína S-100 teve estatisticamente menor poder de marcação tanto na prega vocal (p=0,01) como na pele (p=0,02). Foi possível identificar três diferentes subpopulações de CL presentes tanto na prega vocal como na pele destes indivíduos, contudo apenas na pele observarmos maior quantidade estatisticamente significante na camada basal do epitélio. Langerhans Cells (LC) are a type of dendritic cells that have functions which involves antigen presentation and the stimulation of a T cell response. They represent about 4% of the laryngeal epithelial cells. Aim: The aim of this study was to identify the presence of LC in the epithelium of the vocal folds, to compare their subpopulations, as well as to compare the capacity of four immunohistochemistry markers. Study Design: Experimental. Material and Method: Six cadavers, 3 men and 3 women, were studied. Analysis of vocal folds and skin paraffin blocks stained with commercially available polyclonal S-100, vimentin, CD-68 and fascin were done. After histological analysis, Student t test and Analysis of Variance (ANOVA) were accomplished in the statistical study. Results and Conclusions: It was possible to identify the presence of LC in the epithelium of the human vocal folds in no smokers of both sexes. Fascin, vimentin and CD-68 were superior markers of LC than S-100 polyclonal antibody in vocal folds (p=0,01) and in the skin (p=0,02). It was also possible to identify three different subpopulations of LC in the vocal folds and skin. However, just in the skin it was observed larger amount in the basal layer of the epithelium statistically significant. Palavras-chave: cordas vocais/ anatomia & histologia, células de langerhans, imunohistoquímica. João

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Histology of Laryngeal Mucosa

Cited by 27 publications

References 15 publications

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Vocal Fold Epithelial Barrier in Health and Injury: A Research Review

Paradoxical vocal cord motion disorder: past, present and future

Células de Langerhans no epitélio da prega vocal humana: estudo imunoistoquímico

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