Histology of Submandibular Gland Tumours, 10 Years’ Experience

Becerril-Ramírez, Perla B.; Bravo-Escobar, Gerardo Arturo; Calleros, Héctor Manuel Prado; Castillo-Ventura, Bertha Beatriz; Pombo-Nava, Alejandro

doi:10.1016/j.otoeng.2011.04.004

Cited by 8 publications

(11 citation statements)

References 9 publications

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“…The mean age of occurrence of PA was 39.8 years with female to male ratio of 3.5:1. 3 In present study also, the mean age was 40.2 years with male to female ratio of 1:4 which showed female preponderance.…”

Section: Discussionsupporting

confidence: 66%

“…2 Becerril-Ramírez et al, in their 10-years study found a total of 22 cases of submandibular gland neoplasms, in which 19 cases (86%) were benign and 3 cases (14%) were malignant. 3 Munir and Bradley reviewed series of the pleomorphic adenoma affecting submandibular gland over a period of 16 years and reported that all patients presented with clinically visible and palpable mass of submandibular fossa among which 84% of cases were asymptomatic and 16% presented with pain. 4 Rapidis et al, analyzed clinicopathologic features of 23 patients with submandibular gland tumors, in which nine were benign and 14 were malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic adenoma of submandibular gland: not so common occurrence

et al. 2018

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INTRODUCTIONSalivary gland tumors are uncommon and comprise only 1-4% of head-face-neck tumors. Majority of the salivary gland tumors affect parotid gland with more than 70% of the cases. Several studies have been conducted on the tumors of the parotid and minor salivary glands, but very few reports in the literature have focused on submandibular gland tumors as they are rare and are usually grouped with other salivary glands. Submandibular gland is affected in 5-10% of the cases with pleomorphic adenoma being the most common tumor. 1The most frequent neoplasms in the submandibular glands are: pleomorphic adenoma (36%), adenoid cystic ABSTRACT Background: The salivary glands tumour are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes. Several studies have been conducted on the tumors of the parotid and minor salivary glands, but very few reports in the literature have focused on submandibular gland tumors as they are rare and are usually grouped with other salivary glands. Approximately 70% of the salivary gland tumors affect parotid gland with the submandibular gland being affected in 5-10% of the cases, sublingual gland in 1% and minor glands in 5-15% of the cases. So, author describe a series of 50 patients of pleomorphic adenoma affecting submandibular gland. Methods: The prospective study was conducted at Department of General Surgery, Indira Gandhi Government Medical College, Nagpur between January 2008 to December 2017. Results: Out of the 50 patients, 10 were male and 40 were female. Thus, male to female ratio is 1:4. Most of the 42 (84%) patients presented with painless swelling in submandibular region. Clinically the tumour has the texture of cartilage and has an irregular and bosselated surface observed in all the patients. The size of tumour was 3 to 6 cm in 32 (64%) patients observed in the present study. Fine needle aspiration cytology was performed in all the patients. All patients were managed by surgical excision. Recurrence occurred in a single patient who was managed with radical excision including a neck dissection with postoperative radiotherapy. Conclusions: Submandibular gland pleomorphic adenoma being common benign tumor, occurring commonly between the 3 rd and 5 th decade of life and presenting as slow growing asymptomatic swelling with female preponderance. The precise surgical excision along with whole submandibular salivary gland and postoperative radical radiotherapy required for recurrence as the accepted mode of management. However, further long-term studies involving submandibular gland have to be carried out to know the pattern of tumor recurrence.

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Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Pleomorphic adenoma of submandibular gland: not so common occurrence

et al. 2018

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“…Previous reports have shown that several histopathologic features may predict poor outcome, including a cystic component of less than 20%, 4 or more mitotic figures per 10 high-power fields, neural involvement, necrosis, and anaplasia. [18][19][20] Interestingly, for tumors of equal histopathologic grade, the prognosis appeared to be better if the tumor was located in the parotid gland than in the submandibular gland. 21 In a large study on salivary gland tumors, Goode et al concluded that age, tumor size, and preoperative symptoms affected patient outcome.…”

Section: Discussionmentioning

confidence: 99%

Submandibular Salivary Gland Tumors: Clinical Course and Outcome of a 20-Year Multicenter Study

et al. 2017

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The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. One hundred ninety-three patients were identified, of whom 108 (56%) had non-neoplastic disorders (sialolithiasis and sialadenitis). The remaining 85 patients (44%) had a submandibular salivary gland tumor. The most common benign neoplasm was pleomorphic adenoma (53 patients). Twenty tumors (24%) were malignant: adenoid cystic carcinoma in 11 patients, mucoepidermoid carcinoma in 6 patients, and adenocarcinoma in 3 patients. Recurrence was noted in 7 patients with submandibular gland malignancy and in 2 patients with pleomorphic adenoma. The 5-year disease-free survival rate was 63%. Tumors of the submandibular gland are infrequently malignant. Recurrent submandibular salivary gland pleomorphic adenoma is rare compared with recurrences in the parotid gland.

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“…Th ese tumors are classifi ed as semi-malignant to make clinicians aware of their potential malignant behavior. Th eir multilocular structure, with fi ngerlike elongations, is a reason for possible tumor penetration into the surrounding tissue [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Relapse of Pleomorphic Adenoma from Childhood to Adulthood: Case Report

Grabovac¹

2017

ACC

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Pleomorphic adenoma is rarely seen in childhood. After detailed literature search, we did not come across a case of frequent relapse of this benign tumor from childhood to adulthood. The World Health Organization defines relapse of pleomorphic adenoma as a histologically benign tumor that can have local or distant metastasis. There is one hypothesis how benign tumor can metastasize. According to this hypothesis, probably during the first operative procedure the tissue around the tumor becomes permeable for tumor cells, which can lead to implantation of tumor cells into the surrounding tissue. In this case report, we present a case of a 30-year-old woman with pleomorphic adenoma of the submandibular gland, which relapsed three times. The patient was first operated on in 1993, at the age of 7 years. The first two relapses occurred in 1998 and 2001, at the age of 12 and 15, respectively. The last relapse occurred in 2015, at the age of 29 years. All relapses were localized in the submandibular region on the right side of the neck, where the primary tumor had been operated on.

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Histology of Submandibular Gland Tumours, 10 Years’ Experience

Cited by 8 publications

References 9 publications

Pleomorphic adenoma of submandibular gland: not so common occurrence

Pleomorphic adenoma of submandibular gland: not so common occurrence

Submandibular Salivary Gland Tumors: Clinical Course and Outcome of a 20-Year Multicenter Study

Relapse of Pleomorphic Adenoma from Childhood to Adulthood: Case Report

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