Histology of sun-damaged human skin

Montagna, William; Kirchner, Stephen J.; Carlisle, Kay S.

doi:10.1016/s0190-9622(89)70276-0

Cited by 185 publications

(106 citation statements)

References 39 publications

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“…Another prominent feature of photoaged skin is solar elastosis. 10 Some studies showed that solar elastosis could relate with increased tropoelastin gene expression 11 or an increased expression of fibrillin in the photodamaged skin. 12 In addition, degradation of elastic fibers by UV-induced MMP-12 might contribute to the pathology.…”

Section: Discussionmentioning

confidence: 99%

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Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis

Park

Sohn

Lee

et al. 2010

Journal of the American Academy of Dermatology

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Background: Repeated exposure to ultraviolet radiation from the sun results in premature photoaging. Photodynamic therapy (PDT) has been shown to be effective for treatment of photoaging, although the data from most studies have been based on clinical observation.Objectives: We investigated whether 5-aminolevulinic acid (ALA)-PDT induced histologic changes suggesting photorejuvenation.Methods: Fourteen patients with one to three actinic keratoses on the face were treated twice with ALA-PDT by using a 1200 W metal halogen lamp at 1-month intervals. Skin biopsy before and 1 month after the PDT was performed. Twenty-five pairs of specimens were obtained. We examined the specimens with routine and immunohistochemical staining and evaluated the parameters associated with photoaging by using image analysis.Results: After ALA-PDT, the mean epidermal thickness and dermal inflammatory infiltrate were reduced. The total collagen volume in the dermis significantly increased with expression of type I and III procollagen. The level of transforming growth factor b and transforming growth factor b type II receptors in the epidermis also increased. The elastotic material with co-localizing fibrillin-1 and tropoelastin expression in the dermis decreased after treatment. The expression of matrix metalloproteinases-1, -3, and -12 also decreased.Limitations: The study was limited by the small sample size.Conclusions: ALA-PDT resulted in histological changes indicating restoration of photoaged skin. These data suggest that ALA-PDT could be effective for photorejuvenation. ( J Am Acad Dermatol 2010;62:85-95.)

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Section: Discussionmentioning

confidence: 99%

“…9 Solar elastosis, the deposition of dystrophic elastotic material within the dermis, is also a characteristic of photoaged skin. 10 The mechanism causing this damage remains unclear. However, it may be related to the increased production of elastic fibers, which consist of elastin and fibrillin-rich microfibrils.…”

Section: Introductionmentioning

confidence: 99%

Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis

Park

Sohn

Lee

et al. 2010

Journal of the American Academy of Dermatology

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“…The diagnostic criteria were based on published studies according to the presence or absence of specific changes 9,12,[16][17][18][19][20] shown in Figures 1, 2 and 3 and described below:…”

Section: Methodsmentioning

confidence: 99%

Queilite actínica adjacente ao carcinoma espinocelular do lábio como indicador de prognóstico

Abreu

Silva

Pimentel

et al. 2006

Rev. Bras. Otorrinolaringol.

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Many studies have shown an association between actinic cheilitis and squamous carcinoma of the lips. Aim: The aim of the study was to observe the relation between actinic cheilitis and the prognosis of squamous carcinoma of the lips. Materials and Methods: This is a retrospective crosssectional cohort study of squamous carcinoma of the lips. Histological sections of squamous carcinoma tumors done at the the Departament of Pathology of the Sao Paulo Federal University between 1993 and 2000 were reviewed for evidence of actinic cheilitis in the lip vermillion adjacent to the tumor. Patient reports were reviewed to find information about exposure to sun, metastases and relapses. The occurrence or absence of relapses and metastases was correlated with the presence or absence of actinic cheilitis in the lip vermillion. Data was analyzed by Fisher's Exact test. Results: Of the 31 selected patients, most were caucasian, males and with lower lip involvement. Statistical analysis demonstrated independence between the occurrence of metastases and relapse and gender, skin color and site (lower or upper lips). There was dependence between actinic cheilitis and solar elastosis, and between the absence of actinic cheilitis and the occurrence of metastases. There was no dependence between the absence of actinic cheilitis and the occurrence of relapses. Conclusion: It may be concluded that tumors originating from actinic cheilitis have a better prognosis.

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“…These signs of chronological aging and photo-damage are associated with a general slow-down of cell renewal in the epidermis and loss of collagen synthesis in the dermis [5][6][7][8][9]. It was demonstrated that exposure of skin cells to sunlight radiation is associated with subclinical inflammation that induces release of degrading enzymes such as collagenase (Matrix Metalloproteinase-1, MMP1) and gelatinase (Matrix Metalloproteinase-9, MMP9) that degrades collagen in the dermis [10][11][12], and with the synthesis and accumulation of non functional elastin [13][14][15]. In the epidermis, chronological and photo aging lead to an atrophy of the epidermis with a loss of the micro relief as well as an irregular distribution of melanin [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

Oddos¹,

Roure²,

Leyden³

et al. 2012

JCDSA

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Retinol is an ingredient used in cosmetic products for reducing the appearance of the signs of aging and photo-damage. Currently, most of these products contain 0.1% of retinol. However, at this concentration, some irritation can occur. We have evaluated in vitro and in a clinical study the potential efficacy of a combination of actives to improve the facial skin aging signs while using low concentration of retinol. We demonstrated, in vitro, that a chromone derivative, 5,7-di-hydroxy-2-methyl chromone (DMC), is able to enhance the collagen synthesis in culture of normal human dermal fibroblasts. The enhancement of retinol anti-wrinkle efficacy by DMC was confirmed in a small scale clinical trial. Specifically, a product associating low concentration of retinol (0.04%) and DMC (0.1%) in combination with low molecular weight hyaluronic acid fragments (50,000 Dalton of average molecular weight) has been applied topically for 8 weeks. Clinical results show significant improvement of various signs of facial skin aging such as wrinkles, pigmentary spots, tone unevenness, dullness and the overall photo-damage score. Improvements were still visible 4 weeks after the cessation of the test product application. This study demonstrates that significant lasting improvement of facial skin aging can be obtained with well tolerated low concentration of retinol when adequately formulated with other anti-aging ingredients.

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Histology of sun-damaged human skin

Cited by 185 publications

References 39 publications

Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis

Photorejuvenation induced by 5-aminolevulinic acid photodynamic therapy in patients with actinic keratosis: A histologic analysis

Queilite actínica adjacente ao carcinoma espinocelular do lábio como indicador de prognóstico

A Placebo-Controlled Study Demonstrates the Long-Lasting Anti-Aging Benefits of a Cream Containing Retinol, DihydroxyMethylChromone (DMC) and Hyaluronic Acid

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