Histology of Testes in Klinefelter’s Syndrome

The Klinefelter syndrome: current management and research challenges

“…Of the 120 workshop participants, only Alan Rogol and Eberhard Nieschlag had met Harry Klinefelter in person, the former as one of his medical teachers at John Hopkins in Baltimore and the latter at an International Klinefelter Symposium in Murnau in the Bavarian Alps in 1983 (Bandmann et al, 1984).…”

Robertsonian Translocation Associated with Azoospermia

“…Plasma hor mone levels were within normal ranges in our case. In patients with sex chromosome abnormality, severe hyalinization of seminiferous tubules and hyperplasia of Leydig cells are usually observed [11], Furthermore, hyper gonadotropic hypogonadism is common in sex chromo some abnormality [12]. These facts suggest that histolog ical changes of the testis and hormonal abnormalities are milder in Robertsonian translocation than in sex chro mosome abnormality.…”

An Azoospermic Male with Reciprocal Translocation t(3;4)(p12;q21)

“…Histological studies on tes ticular biopsies from patients with sex chromosome ab normality show severe hyalinization of seminiferous tu bules and hyperplasia of Leydig cells [10], In autosomal translocation, partial or complete arrest of spermatogene sis and slight hyperplasia of Leydig cells are observed [ 11], The histological changes of the testes are considered to be milder in autosomal translocation than in sex chromo some abnormalities. However, the elevation of plasma FSH and severe histological changes in the testis were observed in our case.…”