Histology of Tympanosclerosis

Abstract

Light-and electronmicroscopic studies of tissue from pithological middle ears revealed in sixteen cases changes typical of tympanosclerosis, i.e. collagenous connective tissue poor in cells, with hyaline degeneration and occasional calcium deposits. In one case new formed cartilaginous tissue was present. In several specimens we found granulation tissue, which is assumed to represent the incipient stage in the pathogenesis of tympanosclerosis. Electronmicroscopy has revealed that ths degenerative process involves not only connective tissue, but also the epidermis of the tympanum. It is stressed that the diagnosis of tympanosclerosis can be established only by means of microscopic study of the removed tisrue.

Myringosclerosis Develops within 9 h of Myringotomy

“…Clinical studies have shown that myringosclerotic lesions have dynamic properties and may either increase or decrease both in number and extension [4][5][6][7]. The histology of sclerotic deposits has been thoroughly investigated at both the light-microscopic and at the ultrastructural levels [8][9][10][11]. However, in none of these previous studies was the time course of the development of sclerotic lesions investigated.…”

Ti̇mpanoskleroz Etyoloji̇si̇nde Allerji̇ni̇n Yeri̇

“…Orta kulak mukozasının lokal olarak IgE sentezlediği ve allerjik uyarana cevap olarak effüzyon oluştuğu düşünülmüştür (2,8). Veltri ve Sprinkle, EOM da IgE nin effüzyon/serum oranını birden yüksek bulmuşlar ve orta kulakta IgE nin lokal sentezinden sözederek, IgE bağımlı Tip I hipersensitivite reaksiyonunun EOM patogenezinde rolü olduğunu ileri sürmüşlerdir.…”

Changes of Pars tensa in Secretory Otitis

“…The degree of degeneration, however, varied greatly, ranging from diffuse and massive to localized and minimal tympanosclerosis. In the majority of other ears the tympanosclerosis can prob ably be demonstrated histologically {Sorensen and True, 1971;Tos and BakPedersen, 1974).…”