Histometrical Study of the Pulmonary Arteries in Normal Postnatal Development and in Patients with Ventricular Septal Defect

Honda, Takeo; Horiuchi, T; Abe, Tadaaki; Koyamada, K; Ishitoya, Takeshi; Ishizawa, E

doi:10.1620/tjem.102.403

Cited by 9 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6][7][8] Cross-sections of arterial branches were selected from the histological slide and projected onto a sheet of tracing paper. Arterial sections with severe PVD were discarded because secondary atrophy of the muscular coat might affect the histometrical result.…”

Section: Grading Of Pvdmentioning

confidence: 99%

Quantitative analysis of pulmonary vascular disease in complete transposition of the great arteries.

Yamaki¹,

Tezuka²

1976

Circulation

View full text Add to dashboard Cite

SUMMARY Forty autopsy cases of complete transposition of the great arteries (TGA) and 22 autopsy cases of ventricular septal defect (VSD) were analyzed histologically for evidence of vascular damage due to pulmonary vascular disease (PVD). Positive correlations were generally observed between an index of pulmonary vascular disease (IPVD) and blood pressure of pulmonary circulation. No significant difference in IPVD was found between TGA and VSD in the first five months of life, when cases of each disease were compared at similar blood pressure levels. After that age, however, IPVD was much higher in TGA, and particularly severe PVD in this disease was DEVELOPMENT OF PULMONARY VASCULAR DISEASE (PVD) as a result of pulmonary hypertension in some congenital heart diseases is a major factor in the prognosis and postoperative course of patients. Although the role of pulmonary hypertension in inducing pulmonary vascular lesions is established in general terms, a number of authors have pointed out that complete transposition of the great arteries (TGA) in particular is characterized by early onset and development of severe vascular changes.'-3 The high vulnerability of the pulmonary artery in TGA suggests that factors other than elevated blood pressure also play a role in the production of vascular lesions. For this reason, a structural analysis of the arterial wall may contribute to the understanding of vascular lesions in this disease.Histopathological studies seem to have been limited to direct correlation of histological vascular lesions with clinical records of blood pressure.3 ' The response of the pulmonary artery to elevated blood pressure prior to the appearance of vascular injuries has not yet been sufficiently investigated. Histometrical and histological methods are used in this study to quantitate hypertrophy of the arterial muscular coat and to estimate the grade of vascular lesions. These methods are expected to facilitate the analysis of the behavior of the muscular coat to elevated blood pressure and the relation of pulmonary hypertension to vascular lesions. VSD. None were complicated by other serious cardiac malformations, except for three cases of associated coarctation of the aorta in the age group under 5 months. In three other cases, the patients had each undergone a Mustard procedure at least eight months before death. For comparative analysis, 22 autopsy cases of VSD (aged from 46 days to 24 years), and 33 autopsy cases of apparently normal cardiovascular systems and normal pulmonary circulation (aged from 10 months of gestation to 32 years) were studied. Premature infants were excluded from the control group. Pulmonary arterial pressure had been recorded during catheterization within two months prior to death in 23 cases of TGA and in all the cases of VSD. From the record the peak systolic pressure was estimated in each case and used for correlation with vascular lesions and medial hypertrophy (table 1). About 30 samples of lung were randomly excised from formalin-fixed specimens of both lungs ...

show abstract

Section: Grading Of Pvdmentioning

confidence: 99%

Quantitative analysis of pulmonary vascular disease in complete transposition of the great arteries.

Yamaki¹,

Tezuka²

1976

Circulation

View full text Add to dashboard Cite

show abstract

“…We obtained higher product moment correlations after distribution of the patients into groups of comparable age. For the older children, when the development of the lung vessels usually is finished (13,14,17,22,23), we found a closer relation than in the whole collective. In cases with the same pressure ratios the younger children showed a higher relative thickness of the media than the older patients.…”

Section: Discussionmentioning

confidence: 47%

The correlation between blood pressure and morphometric findings in children with congenital heart disease and pulmonary hypertension

et al. 1981

View full text Add to dashboard Cite

The lungs of 68 children with malformations of the heart or the great vessels which could cause pulmonary hypertension were obtained at autopsy. We analysed the media of muscular pulmonary arteries morphometrically and calculated the area ratio (area media/total area of the vessel). As hemodynamic parameter we used the systolic blood pressure ratio (pulmonary/systemic). Additionally we employed the mean pressure of the pulmonary artery in 38 cases. We analysed the correlation between hemodynamic and morphometric parameters and obtained a product moment correlation of 0.7. There was a linear correlation between the area and pressure ratios. Younger children showed a higher relative thickness of the media than older children with comparable pressure ratios. After dividing the children into three age groups, we obtained an even higher correlation (r = 0.90 in the oldest group). We found these correlations not only in cases with left-to-right shunt but also in children with other heart defects. There was also a good correlation between the quantitatively measured data and the qualitative Heath and Edwards classification.

show abstract

“…The muscular layer is progressively attenuated with advancing postnatal development. Honda et al (1970) demonstrated histometri cally a rapid decline of the medial strength of the pulmonary artery in the first six postnatal months. In rare instances, however, this physiological attenuation of the muscular coat seems to be retarded or incompletely accomplished.…”

Section: Discussionmentioning

confidence: 96%

Histometrical Studies of the Pulmonary Artery in Sudden Death of Young and Apparently Healthy Subjects

Niwa

1971

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Histometrical Study of the Pulmonary Arteries in Normal Postnatal Development and in Patients with Ventricular Septal Defect

Cited by 9 publications

References 9 publications

Quantitative analysis of pulmonary vascular disease in complete transposition of the great arteries.

Quantitative analysis of pulmonary vascular disease in complete transposition of the great arteries.

The correlation between blood pressure and morphometric findings in children with congenital heart disease and pulmonary hypertension

Histometrical Studies of the Pulmonary Artery in Sudden Death of Young and Apparently Healthy Subjects

Contact Info

Product

Resources

About