Histomorphological Characteristics and Pathological Types of Hyperproliferation of Gastric Surface Epithelial Cells

Wang, Yangkun; Shen, Lan; Zhao, Guang Quan; Li, Baohui; Bu, Jianxue; Zhu, Chaoya; Jiang, Bo; Wang, Sunan

doi:10.1155/2021/8828326

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…As such, the method cannot reflect the histopathological characteristics, nor can it provide any information about the relationship between clinical Hp infection and gastric cancer, and is not conducive to evaluating the relationship between Hp infection and carcinogenesis. The authors' previous study found that Hp infection caused a papilloma-like proliferation of glandular epithelial cells 11 and also led to extensive segmental atrophy of the glands in the lamina propria of the gastric mucosa. 12 The World Health Organization classified Hp infection as a carcinogen of gastric cancer, accordingly, giving rise to a trend to eliminate Hp to prevent gastric cancer through the detection and treatment of the bacteria.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa

Wang¹,

Li²,

Zhou³

et al. 2022

JIR

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To investigate the histopathological characteristics of Helicobacter pylori (Hp) infection in the gastric mucosa in the process from occurrence to intraepithelial neoplasia. Methods: Specimens obtained from the endoscopic biopsy and endoscopic submucosal dissection of 2457 cases of gastric Hp infection were observed and assessed in detail using histology and immunohistochemistry techniques. The condition was divided according to the histopathological characteristics of gastric mucosal damage caused by Hp infection. The histopathological characteristics and immunophenotype of each stage were subsequently elucidated. Results: Helicobacter pylori is initially implanted in the mucus layer covered by the epithelium on the surface of the gastric mucosa. It then selectively adheres to the cytoplasm of the surface mucus cells, which makes the oval and spherical particles containing mucus that is wrapped by the bounded membrane in the cytoplasm on the nucleus of the surface mucus cells disappear, while the cytoplasm undergoes spiderweb-like vacuolar degeneration. This leads to the proliferation and transformation of the surface mucous cells before developing into intraepithelial neoplasia. In the process of histomorphology, mucosal ulcers, mucosal lymphoid tissue proliferation, gland atrophy, intestinal epithelial metaplasia, mucosa-associated lymphoid tissue lymphoma, and adenocarcinoma may occur. In this study, the condition was divided into five stages according to the histopathological characteristics of gastric mucosal damage caused by Hp infection, as well as the degree of gastric mucosal damage and involvement depth as follows: the mucus infection stage, the surface epithelial cell infection stage, the lamina propria lesion stage, the mucosal atrophy stage, and the intraepithelial neoplasia stage. Conclusion: Understanding the histopathological characteristics of gastric Hp infection in terms of its occurrence and development into intraepithelial neoplasia is conducive to the precise treatment and tracking of malignant cell transformation, and is of great significance in controlling the occurrence and development of gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa

Wang¹,

Li²,

Zhou³

et al. 2022

JIR

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“…There is some literature available on how to differentiate the severity and stage of MALT lymphoma using histopathological morphology, and this is beneficial for clinicians to provide accurate treatment. In our previous study, we found that H. pylori infection resulted in vacuolar degeneration and papillary proliferation of the glandular epithelium of the gastric mucosa [9] and the gastric mucosa infected by H. pylori showed excessive upward migration and insufficient downward proliferation in the affected regions, resulting in disordered proliferation of stem cells [10].…”

Section: Introductionmentioning

confidence: 99%

Histopathological staging and differential diagnosis of marginal zone lymphoma of gastric mucosa-associated lymphoid tissue

Ge,

Wang,

et al. 2024

European Journal of Gastroenterology &Amp; Hepatology

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The purpose of this study was to explore the histopathological staging and differential diagnosis of marginal zone lymphoma in gastric mucosa-associated lymphoid tissue (MALT lymphoma). We performed detailed histomorphology and immunohistochemistry investigations as well as genetic testing on endoscopic biopsy and endoscopic mucosal resection specimens from 18 patients with gastric MALT lymphoma. We found that gastric MALT lymphoma typically begins as a small, isolated area outside the lymphoid follicular mantle zone or proliferates in a multifocal, patchy manner, gradually spreads to the interfollicular zone, forming diffuse proliferation, invades the gastric mucosal glands, and infiltrates or proliferates into the center of peripheral reactive lymphoid follicles. Abnormally proliferating lymphocytes invade the surrounding lymphoid follicles, resulting in damage, atrophy, and disappearance of their normal follicles as well as of the gastric mucosa glands, forming diffuse proliferation. Redifferentiation and proliferation lead to the transformation of lymphocytes; that is, MALT transitions into highly invasive lymphoma. Based on our findings in this study, we propose the following five stages in the process of development and progression of gastric MALT lymphoma: the stage of cell proliferation outside the lymphoid follicular mantle zone; the stage of heterogeneous proliferative lymphoepithelial lesion; the stage of reactive lymphoid follicular implantation; the stage of lymphoid follicular clonal proliferation; and the stage of MALT transforming into highly invasive lymphoma. We examined the differential diagnosis of histopathological features at each stage. The clinicopathological staging of gastric MALT lymphoma can help clinicians provide accurate treatment and track malignant cell transformation, thus playing a significant role in controlling its development and progression.

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“… 9 Helicobacter pylori infection can lead to a papillary proliferation of the surface epithelial cells. 10 However, how Hp infection leads to gastric mucosa atrophy and the histological structural, as well as the cellular morphological changes that occur during its onset and development, have not been reported. This study aimed to investigate the occurrence and development of Hp infection and its histomorphological features, providing a reliable pathological basis for precise treatment by clinicians.…”

Section: Introductionmentioning

confidence: 99%

How Does Helicobacter pylori Infection Cause Gastric Mucosal Atrophy

Wang¹,

Zhou²,

Meng³

et al. 2022

IDR

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Objective To investigate the occurrence and development of gastric mucosal atrophy due to Helicobacter pylori (Hp) infection and the accompanying histomorphological features. Methods Detailed histological observations and immunohistochemical examinations were conducted via 197 endoscopic biopsies and endoscopic submucosal dissection specimens of gastric mucosal atrophic lesions with gastric Hp infection. Detailed observation was made of columnar cells in the proliferative region of the deep gastric pit and the isthmus of the gastric gland, as well as the upper part of the glandular cervix. Results The infection of the gastric mucosa by Hp firstly led to the proliferative disorder of stem cells in the normal proliferative region of the gastric mucosa. This caused substantial propagation of cells in the proliferative region of the deep gastric pit and the isthmus of the gastric gland, as well as the upper part of the glandular cervix, as a means to replenish the damaged surface mucus cells. However, the propagation of stem cells in the proliferative region was insufficient for downward migration, and the normal physiological process of differentiation into fundic/pyloric gland cells was disrupted, resulting in glandular atrophy of the intrinsic layer of the gastric mucosa. Persistent Hp infection and disruption of stem cell proliferation in the proliferative region subsequently resulted in extensive segmental hyperplasia of the gastric mucosa and glandular atrophy of the lamina propria. Conclusion The occurrence, development, and histomorphological features of gastric mucosal atrophy due to gastric Hp infection provide a reliable pathological basis for precise treatment by clinicians and are of great significance for controlling the development of gastric cancer.

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Histomorphological Characteristics and Pathological Types of Hyperproliferation of Gastric Surface Epithelial Cells

Cited by 5 publications

References 30 publications

Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa

Histopathological Features of Helicobacter pylori Infection in Gastric Mucosa

Histopathological staging and differential diagnosis of marginal zone lymphoma of gastric mucosa-associated lymphoid tissue

How Does Helicobacter pylori Infection Cause Gastric Mucosal Atrophy

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