Histomorphological Pattern of Non-Neoplastic and Pre-Neoplastic Lesions of Cervix

Jain, Rashmi; Nigam, Rajendra Kumar; Malik, Reeni; Jain, Parul; Trichal, V. K.; Shrivastava, Abhishek

doi:10.14260/jemds/2016/1116

Cited by 1 publication

(1 citation statement)

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“…17 Jain et al observed that few patients presented with abnormal vaginal bleeding in his study which excluded malignant cases. 18 Other complaints observed in this study were vaginal discharge, uterovaginal prolapse, and abnormal colposcopy finding which include cervical masses, gross alteration in cervical appearance, and cervical erosion. Few patients had no symptom but had cytology report of high-grade intraepithelial lesion that led them to having cervical biopsy.…”

Section: Discussionmentioning

confidence: 62%

Spectrum, Clinicopathologic Profile, and p16 Expression Pattern of Nonmalignant Cervical Tissues in Enugu, South-East Nigeria

Eni,

Ndukwe,

Olusina

et al. 2023

Ibnosina Journal of Medicine and Biomedical Sciences

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Background p16 is a marker for p16-induced transformation of high-risk human papilloma virus (hrHPV)-infected cervical epithelium. HPV is a known etiologic agent of cervical cancer. Persistent hrHPV infection of cervical epithelium causes transformation of the infected epithelial cells resulting in increased proliferative potential of the cells and subsequent progression to frank malignancy. Early detection of transformation in cervical cells is crucial in reducing morbidity and mortality associated with cervical cancer. Materials and Methods We aimed to study the clinicopathologic profile of nonmalignant cervical lesions and their p16 staining pattern. Histopathology requisition forms, blocks, and slides of cases containing cervical tissue with nonmalignant diagnosis received into the morbid anatomy department of University of Nigeria Teaching Hospital, Enugu, from 2009 to 2018 were studied. Fresh sections from the blocks were immunohistochemically stained with p16 and examined. Results One-hundred and ninety-one cases were studied. Majority of the cases are normal cervical epithelium. Chronic nonspecific cervicitis was the major non-neoplastic lesion present and accounted for 33.3% of the biopsy and the mean age was 50.5 years. Other lesions were nabothian cyst (8.4%), cervical polyp (10.5%), low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL; 6.3 and 2.6%, respectively). The mean age for LSIL was 40.3 years, while that of HSIL was 45.2years. Four LSIL, two HSIL, one polyp, one chronic nonspecific cervicitis, and one lobular endocervical hyperplasia stained positively with p16. Conclusion The most common benign lesion of the cervix is cervicitis. Chronic cervicitis is negative to p16 immunoreactivity. There are more low-grade cervical intraepithelial neoplasia (CIN) than high-grade CIN. The low-grade CIN overexpress p16 in one-third of cases. There are more cases of p16-negative high-grade CIN in this study.

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Section: Discussionmentioning

confidence: 62%