Histomorphometric Comparative Analysis between Oral Dysplastic Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Pereira, Natália; Pinheiro, Tiago Novaes

doi:10.1055/s-0039-1688734

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Furthermore, eosinophils infiltration was elevated in OSCC compared to dysplastic lesions suggesting that eosinophils may be necessary for malignant transformation (51). Similarly, both mast cells and eosinophil infiltration were increasingly elevated during the progression from normal epithelium to dysplasia to invasive cancer (52)(53)(54)(55). Currently, it remains unclear how other granulocytic cells alter the tumor microenvironment to facilitate the development pre neoplastic lesions and their transition to invasive cancer.…”

Section: The Evolution Of the Immunosuppressive Microenvironment In Oplmentioning

confidence: 99%

Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy

et al. 2022

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Oral premalignant lesions (OPLs) are the precursors to oral cavity cancers, and have variable rates of progression to invasive disease. As an intermediate state, OPLs have acquired a subset of the genomic alterations while arising in an oral inflammatory environment. These specific genomic changes may facilitate the transition to an immune microenvironment that permits malignant transformation. Here, we will discuss mechanisms by which OPLs develop an immunosuppressive microenvironment that facilitates progression to invasive cancer. We will describe how genomic alterations and immune microenvironmental changes co-evolve and cooperate to promote OSCC progression. Finally, we will describe how these immune microenvironmental changes provide specific and unique evolutionary vulnerabilities for targeted therapies. Therefore, understanding the genomic changes that drive immunosuppressive microenvironments may eventually translate into novel biomarker and/or therapeutic approaches to limit the progression of OPLs to potential lethal oral cancers.

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Section: The Evolution Of the Immunosuppressive Microenvironment In Oplmentioning

confidence: 99%

Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy

et al. 2022

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“…The presence of atypical and degranulated mast cells was found in cases with the presence of moderate and intense inflammatory infiltrate. Pereira and Pinheiro [2019] ( 18 ), in a comparative study between potentially malignant lesions and oral squamous cell carcinoma, found that mast cell density was lower in oral leukoplakia when compared to lesions of (OSCC), which in turn presented a significant increase in mast cells and microvessels suggesting tumor progression and aggression through the positive regulation of angiogenesis by these cells. Sathyakumar et al [2012] ( 17 ), reported the highest concentration of mast cells and blood vessels in oral leukoplakia lesions when compared to the normal oral mucosa.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric comparative analysis between the oral mucosa of fibrous inflammatory hyperplasia and oral leukoplakia

Silva¹,

Pinheiro²

2020

Transl Cancer Res TCR

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Background Oral leukoplakia is the most common potentially malignant lesion, the etiology of this change is still uncertain which makes it difficult to predict when this will undergo malignant transformation. Recent studies have examined the involvement of mast cells in this process, it is believed that these cells through the release of pro-angiogenic factors influence the processing mechanism of such lesions through promoting angiogenesis. It was the objective of this study to evaluate the inflammatory process in oral leukoplakia comparing it to a non-cancerous lesion correlating the intensity of mast cells with inflammatory infiltrate and vascularization in these lesions. Methods A total of 20 selected cases divided into two groups, oral leukoplakia and inflammatory fibrous hyperplasia (IFH). Histochemical Technique of Toluidine Blue was applied to enhance mast cells and histomorphometry for quantifying mast cells, blood vessels and inflammatory cell infiltration by capturing digital images of the samples and analysis software Image Java version 1.48v. Mast cells and blood vessels were counted in 10 different areas and the intensity of the inflammatory infiltrate was measured in three areas. The analysis of variance (ANOVA) was used for between-group variation, a P value of 0.05 for statistical significance. Results It was observed a reduction in the concentration of mast cells in oral leukoplakia compared fibrous inflammatory hyperplasia. In contrast to the concentration of blood vessels were present in higher concentrations in the Oral leukoplakia lesions. The inflammatory infiltrate in most cases was considered scarce, except in a case where that IFH was intense and a case of moderate inflammatory infiltrate in oral leukoplakia. Conclusions The results showed reduction in the number of mast cells in the oral leukoplakia and greater intensity in the inflammatory process in the IFH, suggesting a possible carcinogenic influence in the microenvironment oral leukoplakia.

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“…Angiogenesis facilitates the invasion and metastasis of cancer cells by remodeling the TME, and provides increased oxygen and nutrients for tumor growth. In the context of OSCC, a positive correlation between the MC and vascular densities in OSCC has been recently established, suggesting the ability of these cells to regulate angiogenesis [ 107 ]. This may explain the aggressive behavior and metastatic tendencies of these oral tumors.…”

Section: Oscc Immune Permissive Environment Induced By Periodontal Diseasementioning

confidence: 99%

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

Elebyary

Barbour

Fine

et al. 2021

Front. Oral. Health

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Periodontitis (PD) is increasingly considered to interact with and promote a number of inflammatory diseases, including cancer. In the case of oral squamous cell carcinoma (OSCC) the local inflammatory response associated with PD is capable of triggering altered cellular events that can promote cancer cell invasion and proliferation of existing primary oral carcinomas as well as supporting the seeding of metastatic tumor cells into the gingival tissue giving rise to secondary tumors. Both the immune and stromal components of the periodontium exhibit phenotypic alterations and functional differences during PD that result in a microenvironment that favors cancer progression. The inflammatory milieu in PD is ideal for cancer cell seeding, migration, proliferation and immune escape. Understanding the interactions governing this attenuated anti-tumor immune response is vital to unveil unexplored preventive or therapeutic possibilities. Here we review the many commonalities between the oral-inflammatory microenvironment in PD and oral-inflammatory responses that are associated with OSCC progression, and how these conditions can act to promote and sustain the hallmarks of cancer.

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Histomorphometric Comparative Analysis between Oral Dysplastic Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Cited by 9 publications

References 18 publications

Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy

Genetic Changes Driving Immunosuppressive Microenvironments in Oral Premalignancy

Histomorphometric comparative analysis between the oral mucosa of fibrous inflammatory hyperplasia and oral leukoplakia

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

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