Histomorphometric comparison between continuous and discontinuous distraction osteogenesis

Djasim, Urville M.; Mathot, Bas J.; Wolvius, Eppo B.; Neck, Johan W. van; Wal, K.G.H. van der

doi:10.1016/j.jcms.2009.03.006

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…These results corroborate with literature findings. [5–717] In agreement with the study by Djasim et al .,[16] we found new bone trabeculae formation in all groups, filled with fibrovascular tissues, and where the bone trabeculae were aligned in the direction vector of OD we found on the central area a minor quantity of bone formation, that indicates the limits/border of preexisting bone, and diminishing on the central area direction.…”

Section: Resultssupporting

confidence: 92%

“…[1314] In the present study the protocol activation of the device was 0.7 mm/day that is suggested by literature. Activations of 0.5 to 1 mm/day result in new bone formation, but when within large distraction sites and with a shorter duration, OD has been shown to form fibrous connections,[1516] and this situation was not observed in this present investigation. The results of these investigations have been tabulated in Table 3.…”

Section: Resultsmentioning

confidence: 51%

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Histological and physical analysis of bone neoformation by osteogenesis distraction: A preliminary report

Vannucci

Dreyer

Kreisner

et al. 2011

Ann Maxillofac Surg

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Introduction:Osteogenesis distraction (OD) is a mainstream technique in maxillofacial surgical reconstruction with varied applications. OD technique employs a distractor with the aim to get new bone in the site of interest. Osseous maturation time is necessary before the device can be removed and few patients’ complaint of related discomfort, especially when these devices are external, and induces superficial infections, paresthesia, hypertrophic scars and social relationship difficulties. The use of Low Level Laser Therapy (LLLT) has been proved beneficial to soft tissue and osseous repairs.Materials and Method:12 rabbits were randomly divided in to two groups. In all animals, distractor was placed and one group was exposed to LLLT while the other group served as control. After consolidation, animals were sacrificed, the new bone formed were subjected to investigations including histomorphometric, physical analysis and tomographical analysis. Statistical analyses were performed using SPSS software.Result:Newly formed bone was significantly different between the groups. The physical properties of the neobone were comparatively better when the animals were exposed to LLLT with varying statistical significance.Conclusion:The results obtained with smaller sample size in this study need to be interpreted with care. The results of this preliminary pilot study encourage the use of LLLT during healing period. However the histological, tomographical and physical findings need to be ascertained using a larger sample size to study the bio-stimulatory effects with laser therapy from basics to clinical relevance on wound and bone healing.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 51%

Histological and physical analysis of bone neoformation by osteogenesis distraction: A preliminary report

Vannucci

Dreyer

Kreisner

et al. 2011

Ann Maxillofac Surg

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“…No presente estudo, foi utilizado um protocolo de ativação do aparelho de 0,7 mm/dia, pois, segundo a literatura, ativações de 0,5 a 1mm/dia resultam em formação óssea, enquanto que distrações maiores e mais rápidas resultam em união fibrosa, fato não observado nesta investigação. 9,15,16 Apesar de estarem bem descritos e consagrados os eventos que ocorrem durante o processo de alongamento ósseo por DO, inclusive quando da irradiação com laser, julgou-se importante a realização deste estudo, a fim de avaliar as características físicas e histológicas do osso neoformado com e sem irradiação com laser 5,6,17 . Os resultados foram compilados e expressos conforme se apresenta no Quadro 2.…”

Section: Resultsunclassified

Osso neoformado por distração osteogênica: análises histológicas e físicas

Dreyer

Vannucci²,

Kreisner³

et al. 2011

cmbio

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<p class="MsoNormal" style="text-align: justify; line-height: normal; margin: 0in 0in 0pt 4.5pt; mso-layout-grid-align: none;">Este estudo teve como objetivo avaliar, por métodos histológicos, tomográficos e físicos, o efeito do laser de baixa potência (LLLT – 830 nm) no osso neoformado em mandíbulas de coelhos submetidas à fratura, sem ou com distração osteogênica (DO). Foi utilizado um total de doze coelhos. Para as análises histológicas, foram utilizados oito (quatro para o grupo de controle e quatro para o experimental), além de quatro coelhos para as análises tomográficas e físicas (um não-distraído e sem irradiação laser; um não-distraído e com irradiação laser; um distraído e sem irradiação laser; um distraído e com irradiação laser). Para os coelhos que sofreram alongamento ósseo por DO, foi adotado o seguinte protocolo: latência – três dias; ativação – sete dias 0,7mm/d; e consolidação – dez dias. Para os animais irradiados, utilizou-se o laser infravermelho (GaAl)As (J=830 nm, 40 mW) com o seguinte protocolo: dose pontual de 10 J/cm2, diretamente sobre o sítio ósseo submetido à fratura e (ou) DO, no período de consolidação óssea, respeitando-se intervalos de 48 horas. O percentual do osso neoformado foi maior no grupo com LLLT (57,89%) do que no de controle (46,75%), p=0,006. A análise tomográfica revelou aumento da densidade, medida em Unidades Hounsfield (HU), dos ossos fraturados que foram irradiados com laser. Com relação às propriedades físicas, nos ossos submetidos à DO, o laser não promoveu alteração da nanodureza, mas modificou os valores do módulo de elasticidade. A composição química revelou, a partir das razões de Ca e P, uma mineralização maior no grupo com LLLT. Os percentuais de cristalinidade indicaram maiores percentuais cristalinos nos coelhos com LLLT. As amostras indicaram semelhança da estrutura cristalina com as hidroxiapatitas, a partir dos difratogramas obtidos. Concluiu-se que o LLLT apresentou efeito positivo na densidade, no percentual de osso neoformado, na composição química e na cristalinidade do sítio da DO. </p>

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“…Further, the studies [5,6] provide the advantages of continuous DO for bone regeneration acceleration. For complex deformations, surgical methods are applied.…”

Section: Introductionmentioning

confidence: 99%

Method for Automated Bone Shape Correction within Bone Distraction Procedure

Blynskiy

2016

J. Phys.: Conf. Ser.

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Abstract. The method for automated bone shape correction within bone distraction procedure is presented. High precision deformation angle measurement is provided by the software for XRay images processing. Special BDC v.1.0.1. application is designed. The purpose of the BDC is modeling of the bone geometry structure to calculate the appropriate distraction forces. The correction procedure control is realized by the hardware of the distraction system.

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Histomorphometric comparison between continuous and discontinuous distraction osteogenesis

Cited by 18 publications

References 33 publications

Histological and physical analysis of bone neoformation by osteogenesis distraction: A preliminary report

Histological and physical analysis of bone neoformation by osteogenesis distraction: A preliminary report

Osso neoformado por distração osteogênica: análises histológicas e físicas

Method for Automated Bone Shape Correction within Bone Distraction Procedure

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