Histomorphometric evaluation of 3D printed graphene oxide-enriched poly(ε-caprolactone) scaffolds for bone regeneration

Alazab, Maha H.; Abouelgeit, Salma A.; Aboushelib, Moustafa N.

doi:10.1016/j.heliyon.2023.e15844

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…Also, studies by Li et.al showed that human adipose stem cells differentiated toward osteogenic lineage on 3D printed alginate-based scaffolds coated with GO [82]. Several studies have shown the combination of synthetic polymers, such as PCL, PLLA, PVA, and PLA, and graphene-based materials for the development of 3D printed bone scaffolds with high compressive strength, modulus, cytocompatibility, and bioactivity for osteogenesis [88,[169][170][171][172][173]. Finally, 3D printed graphene-based scaffolds have demonstrated tremendous impact on the treatment of osteosarcoma and bone regeneration [144,174].…”

Section: Hard Tissue Engineeringmentioning

confidence: 99%

Graphene in 3D Bioprinting

Patil,

Alimperti

2024

JFB

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Three-dimensional (3D) bioprinting is a fast prototyping fabrication approach that allows the development of new implants for tissue restoration. Although various materials have been utilized for this process, they lack mechanical, electrical, chemical, and biological properties. To overcome those limitations, graphene-based materials demonstrate unique mechanical and electrical properties, morphology, and impermeability, making them excellent candidates for 3D bioprinting. This review summarizes the latest developments in graphene-based materials in 3D printing and their application in tissue engineering and regenerative medicine. Over the years, different 3D printing approaches have utilized graphene-based materials, such as graphene, graphene oxide (GO), reduced GO (rGO), and functional GO (fGO). This process involves controlling multiple factors, such as graphene dispersion, viscosity, and post-curing, which impact the properties of the 3D-printed graphene-based constructs. To this end, those materials combined with 3D printing approaches have demonstrated prominent regeneration potential for bone, neural, cardiac, and skin tissues. Overall, graphene in 3D bioprinting may pave the way for new regenerative strategies with translational implications in orthopedics, neurology, and cardiovascular areas.

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Section: Hard Tissue Engineeringmentioning

confidence: 99%

Graphene in 3D Bioprinting

Patil,

Alimperti

2024

JFB

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“…Surface properties of biomaterials obviously can be analyzed not only by MSI methods, but many others can also serve in this field. A typical example could be given: atomic force microscopy (AFM) [ 1 , 2 ], Raman spectroscopy [ 3 , 4 ], X-ray photoelectron spectroscopy (XPS) [ 5 , 6 ], energy dispersive X-ray spectroscopy (EDX) [ 7 , 8 ], Fourier transform infrared spectroscopy (FT-IR) [ 9 , 10 ] or scanning electron microscopy (SEM) [ 11 , 12 , 13 ]. In fact, several of the above-mentioned methods are simultaneously used to obtain reliable results.…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry Imaging of Biomaterials

Kret,

Bodzon-Kulakowska,

Drabik

et al. 2023

Materials

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The science related to biomaterials and tissue engineering accounts for a growing part of our knowledge. Surface modifications of biomaterials, their performance in vitro, and the interaction between them and surrounding tissues are gaining more and more attention. It is because we are interested in finding sophisticated materials that help us to treat or mitigate different disorders. Therefore, efficient methods for surface analysis are needed. Several methods are routinely applied to characterize the physical and chemical properties of the biomaterial surface. Mass Spectrometry Imaging (MSI) techniques are able to measure the information about molecular composition simultaneously from biomaterial and adjacent tissue. That is why it can answer the questions connected with biomaterial characteristics and their biological influence. Moreover, this kind of analysis does not demand any antibodies or dyes that may influence the studied items. It means that we can correlate surface chemistry with a biological response without any modification that could distort the image. In our review, we presented examples of biomaterials analyzed by MSI techniques to indicate the utility of SIMS, MALDI, and DESI—three major ones in the field of biomaterials applications. Examples include biomaterials used to treat vascular system diseases, bone implants with the effects of implanted material on adjacent tissues, nanofibers and membranes monitored by mass spectrometry-related techniques, analyses of drug-eluting long-acting parenteral (LAPs) implants and microspheres where MSI serves as a quality control system.

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3D‐printed graphene‐reinforced composites: Opportunities and challenges

Banupriya,

Jeevan,

Divya

et al. 2024

Polymer Composites

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Abstract3D printing, also known as additive manufacturing, is an innovative technology that allows for the construction of complex, three‐dimensional structures layer by layer using digital plans. This technology has transformed industries including as aerospace, automotive, healthcare, and consumer items by allowing for rapid prototyping, customization, and the manufacture of complex geometries. Graphene, a single layer of carbon atoms organized in a hexagonal lattice, is well‐known for its superior electrical and thermal conductivity, as well as its great tensile strength. When graphene is mixed with composite materials, it greatly improves their mechanical and functional properties, resulting in composites with higher strength, conductivity, lower weight, and greater durability. The combination of 3D printing and graphene‐reinforced composites creates new opportunities for the production of high‐performance, application‐specific structures. This review identifies key advancements in the synthesis, processing, and application of these composites, while also addressing critical challenges such as material dispersion, scalability, and the impact of graphene on the 3D printing process itself. A significant conclusion of this review is the recognition that overcoming these challenges is not only feasible but essential for harnessing the full potential of 3D‐printed graphene‐reinforced composites across diverse industrial sectors. The unique contribution of this work lies in providing a comprehensive roadmap for future research, guiding efforts to bridge current gaps and drive innovation in this emerging field.

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Histomorphometric evaluation of 3D printed graphene oxide-enriched poly(ε-caprolactone) scaffolds for bone regeneration

Cited by 8 publications

References 31 publications

Graphene in 3D Bioprinting

Graphene in 3D Bioprinting

Mass Spectrometry Imaging of Biomaterials

3D‐printed graphene‐reinforced composites: Opportunities and challenges

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