Histomorphometric Evaluation of Cortical Bone Thickness Surrounding Miniscrew for Orthodontic Anchorage

Deguchi, Toru; Yabuuchi, Toshinori; Hasegawa, Masakazu; Garetto, Lawrence P.; Roberts, W. Eugene; Takano‐Yamamoto, Teruko

doi:10.1111/j.1708-8208.2009.00197.x

Cited by 32 publications

(23 citation statements)

References 13 publications

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“…However, Deguchi et al . found that compressive stress enhances the osteogenesis of cortical bone around miniscrews and the miniscrew-bone contact rate7. These findings suggested that compressive stress may regulate activities of both osteoblast and osteoclast.…”

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confidence: 87%

Magnitude-dependent response of osteoblasts regulated by compressive stress

Shen

Geng

Liu

et al. 2017

Sci Rep

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The present study aimed to investigate the role of magnitude in adaptive response of osteoblasts exposed to compressive stress. Murine primary osteoblasts and MC3T3-E1 cells were exposed to compressive stress (0, 1, 2, 3, 4, and 5 g/cm2) in 3D culture. Cell viability was evaluated, and expression levels of Runx2, Alp, Ocn, Rankl, and Opg were examined. ALP activity in osteoblasts and TRAP activity in RAW264.7 cells co-cultured with MC3T3-E1 cells were assayed. Results showed that compressive stress within 5.0 g/cm2 did not influence cell viability. Both osteoblastic and osteoblast-regulated osteoclastic differentiation were enhanced at 2 g/cm2. An increase in stress above 2 g/cm2 did not enhance osteoblastic differentiation further but significantly inhibited osteoblast-regualted osteoclastic differentiation. This study suggested that compressive stress regulates osteoblastic and osteoclastic differentiation through osteoblasts in a magnitude-dependent manner.

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confidence: 87%

Magnitude-dependent response of osteoblasts regulated by compressive stress

Shen

Geng

Liu

et al. 2017

Sci Rep

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“…Therefore the thickness of dense cortical bone has been suggested as a critical factor affecting the primary stability of miniscrews, (Deguchi et al 2011) and larger diameter miniscrews have showed a higher removal torque than smaller ones, (Wilmes et al 2006;Topcuoglu et al 2013) which means better stability. However, there is a limitation to improving stability by increasing the diameter of miniscrews because they should be small enough to be placed into the narrow area between the roots of the teeth.…”

Section: Introductionmentioning

confidence: 99%

Effect of TiO2 nanotubes arrays on osseointegration of orthodontic miniscrew

Jang

Shim

Choi

et al. 2015

Biomed Microdevices

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To increase the stability of orthodontic miniscrews, TiO2 nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly ordered TiO2 nanotube arrays were grown on the surface of orthodontic miniscrews. Ethylene glycol based electrolyte was used in the anodic oxidation process. Two-step anodic oxidation was conducted to obtain clean and open windows in TiO2 nanotube arrays. The diameter and length of the TiO2 nanotube arrays were ~ 70 nm and ~ 5 μm, respectively. The miniscrews with TiO2 nanotube arrays were implanted in the legs of New Zealand white rabbits for 8 weeks. Histological osseointegration was assessed by bone-to-implant contact ratio, and three-dimensional bone volume ratio was measured by micro-computed tomography analysis. The miniscrews with TiO2 nanotube arrays had a greater mean bone-to-implant contact ratio of 52.8 % than the control, 29.3 %. Mean bone volume ratio (BV/TV) was also higher in the miniscrews with TiO2 nanotube arrays, at 81.2 % than those in the control via micro-CT analysis. Our findings support that TiO2 nanotube arrays on the surface of miniscrews enhance osseointegration and improve the stability of the miniscrew.

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“…One is the low mechanical stability between the miniscrew and the cortical bone. 1,[16][17][18] This results in even higher failure rates in patients with a high mandibular plane angle 1,19 and in growing patients 20 than in patients with a low or an average mandibular plane angle and adult patients. Another factor is the close proximity of the miniscrew to the dental root.…”

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confidence: 93%