Histomorphometric evaluation of highly bioactive glass processed in implant surface: an experimental study

Effect of titanium surface functionalization with bioactive glass on osseointegration: An experimental study in dogs

“…To date, few studies have evaluated thin bioactive glass films deposited onto Ti surfaces (Goller, ; Izquierdo‐Barba et al, ; Lopez‐Esteban et al, ; Saiz et al, ; Xuereb, Camilleri, & Attard, ). This was mainly due to the fact that differences in the thermal expansion coefficients of bioglass and medical grade Ti alloys resulted in the low adhesion values of such coatings (Cao & Hench, ; Goller, ; Xuereb et al, ) and in chips off the implant, which in turn could lead to negative biological effects (Granito et al, ; Zanetta‐Barbosa et al, ). Although different coating technologies have been proposed to improve the mechanical properties of bioglass coatings (Junker et al, ), most of them are not integrated by the industry due to complexity, high cost, and inconclusive results when tested in vivo.…”

“…In vitro (Kido et al, 2013;Moura et al, 2007) and in vivo studies (Granito et al, 2009;Kido et al, 2013;Pinto et al, 2013;Renno et al, 2013) evaluating BSF18 as a bone graft substitute have confirmed that it exhibits biological performance similar to Biosilicate and the gold standard 45S5 Bioglass ® . Implants functionalized with BSF18, however, failed to exhibit statistically significant differences in osseointegration parameters compared to uncoated microrough implants (Chinaglia et al, 2012;Zanetta-Barbosa et al, 2013). A new method for the functionalization of implants with BSF18, protected by the patent BR10 2014 003817 5, was thus developed.…”