Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes

Giglio, M.J.; Giannunzio, G.; Olmedo, Daniel Gustavo; Guglielmotti, M.B.

doi:10.1097/00008505-200009020-00006

Cited by 45 publications

(58 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At 14 days post-implantation the animals were killed by ether overdose, the tibiae were resected, fixed in formalin and radiographed. At 14 days post-implantation the experimental model employed in the present study exhibits unequivocal evidence of periimplant laminar bone tissue formation 7,11,28 .…”

Section: Surgical Proceduresmentioning

confidence: 63%

See 1 more Smart Citation

Local effect of titanium implant corrosion: an experimental study in rats

Olmedo

Duffó

Cabrini

et al. 2008

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

Section: Surgical Proceduresmentioning

confidence: 63%

“…The experimental model used in the present study is a suitable method to study newly formed bone around laminar implants under local and/or systemic conditions 7,[11][12][13]28 .…”

Section: Discussionmentioning

confidence: 99%

Local effect of titanium implant corrosion: an experimental study in rats

Olmedo

Duffó

Cabrini

et al. 2008

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

“…Thus, T1-diabetes likely influences both osteoblast number and maturation. Diabetes-associated suppression of osteoblast maturation is also suggested by: (1) reduced bone implant/healing of diabetic rat calvarial defects [Shyng et al, 2001], (2) decreased bone formation around titanium or hydroxyapatite bone implants [Takeshita et al, 1997;Giglio et al, 2000;Siqueira et al, 2003], and (3) decreased alveolar (jaw) bone formation [Mishima et al, 2002]. In bone marrow ablated mice, the ability of T1-diabetic mice to make bone was decreased (marked by decreased runx2 and osteocalcin mRNA levels) compared to controls at 4 and 6 days after ablation [Lu et al, 2003].…”

Section: T1-diabetic Bone Loss-osteoblast Activity Is Decreasedmentioning

confidence: 99%

Understanding the pathology and mechanisms of type I diabetic bone loss

McCabe

2007

J of Cellular Biochemistry

214

183

View full text Add to dashboard Cite

Type I (T1) diabetes, also called insulin dependent diabetes mellitus (IDDM), is characterized by little or no insulin production and hyperglycemia. One of the less well known complications of T1-diabetes is bone loss which occurs in humans and animal models. This complication is receiving increased attention because T1-diabetics are living longer due to better therapeutics, and are faced with their existing health concerns being compounded by complications associated with aging, such as osteoporosis. Both male and female, endochondrial and intra-membranous, and axial and appendicular bones are susceptible to T1-diabetic bone loss. Exact mechanisms accounting for T1-diabetic bone loss are not known. Existing data indicate that the bone defect in T1-diabetes is anabolic rather than catabolic, suggesting that anabolic therapeutics may be more effective in preventing bone loss. Potential contributors to T1-diabetic suppression of bone formation are discussed in this review and include: increased marrow adiposity, hyperlipidemia, reduced insulin signaling, hyperglycemia, inflammation, altered adipokine and endocrine factors, increased cell death, and altered metabolism. Differences between T1-diabetic- and age-associated bone loss underlie the importance of condition specific, individualized treatments for osteoporosis. Optimizing therapies that prevent bone loss or restore bone density will allow T1-diabetic patients to live longer with strong healthy bones.

show abstract

“…Failure may occur during the phase of periimplant bone healing or at a later date, leading to the loss of osseointegration. [3][4][5][6][7][8][9][10][11][12][13][14] Furthermore, Gwyniolo 11 has shown that early osseointegration may undergo changes induced by the material itself or by the environment, as have others. 15 Within this context, corrosion is one of the etiological factors that causes complication.…”

mentioning

confidence: 99%