Histomorphometry of mast cells in the convexity of human intracranial dura mater

Rosas, Emanuela Paz; Paz, Silvânia Tavares; Costa, Raisa Ferreira; Silva, Amanda A da; Silva, Romildo L da; Silva, Ana P F da; Silva, Sabrina R S da; Medeiros, Paloma Lys de; Freitas, Manuela Figueiroa Lyra de; Valênça, Marcelo Moraes

doi:10.1111/joa.13585

Cited by 5 publications

(3 citation statements)

References 57 publications

(62 reference statements)

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“…Recently, we described the histomorphometric aspects of mast cells located in the convexity of the human dura mater. 8 We observed that the mast cells are located close to blood vessels, with a more significant number of cells next to the venous vessels of the periosteal layer and in the proximal region of the superior sagittal sinus. 8 Different from rat (with two), three distinctive dural layers (periosteal, meningeal, and dural border cell layers) are identified in the human dura mater, with a thickness of 564 ± 50 µm.…”

Section: Discussionmentioning

confidence: 61%

“…8 We observed that the mast cells are located close to blood vessels, with a more significant number of cells next to the venous vessels of the periosteal layer and in the proximal region of the superior sagittal sinus. 8 Different from rat (with two), three distinctive dural layers (periosteal, meningeal, and dural border cell layers) are identified in the human dura mater, with a thickness of 564 ± 50 µm. 12 The cells are slightly erratically oriented in the periosteal and meningeal layers.…”

Section: Discussionmentioning

confidence: 61%

“…[5][6][7] Several studies have looked at the involvement of dura mater mast cells as a co-factor in the generation of migraine pain, particularly regarding the hypothesis of neurogenic inflammation. [8][9][10] Little is known about mast cells in the pericranium.…”

Section: Introductionmentioning

confidence: 99%

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Presence of mast cells in the rat pericranium – a tissue very sensitive to pain

et al. 2023

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ObjectiveTo evaluate mast cell presence in the pericranium of Wistar rats.MethodsFive male rats of the Wistar strain were used. The animals were housed under a 12 h light cycle with ad libitum access to food and water and allowed 10 days of acclimatization before tissue sampling. The five rats were anesthetized by intraperitoneal injection of ketamine/xylazine, 10/20 mg/kg. Following aseptic preparation of the head skin, a midline longitudinal incision was made to expose the pericranium. Two samples of the pericranium were taken, one from the right and one from the left. These samples were fixed in 10% buffered formaldehyde for 24 h. After fixation, tissue samples were paraffin-embedded and sectioned at 4 μm. Then, slides were deparaffinized, stained with a concentration of 0.1% toluidine blue for 1 min, and washed with distilled water. Last, slides were photomicrographed under 400x magnification to identify mast cells.ResultsMast cells were identified in the dura mater and the five rats' pericranium. In the dura mater, mast cells were also found in these rats. We found both granulated (intact) and degranulated mast cells.ConclusionWe suggest that future preclinical studies investigating the involvement of dural mast cells and other meningeal cell populations should also include pericranium samples to explore this structure's relevance in migraine pain and other headache disorders.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 61%

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Presence of mast cells in the rat pericranium – a tissue very sensitive to pain

et al. 2023

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Is calcitonin gene-related peptide (CGRP) the missing link in food histamine-induced migraine? A review of functional gut-to-trigeminovascular system connections

de Mora,

Messlinger

2024

Drug Discovery Today

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IL-33 triggers lung autophagy in anaphylaxis mice models

Haggag,

El-Shinnawy,

Badr

et al. 2024

JoBAZ

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Background The relationship between the alarming cytokine interleukin-33 (IL-33) and lung autophagy in systemic anaphylaxis mouse models is not yet fully elucidated, hence, the current study attempts to explain the regulation of lung autophagy in systemic anaphylactic mouse models. IL-33 plays a critical role in endoplasmic reticulum (ER) stress and autophagy regulation via insulin-like growth factor-binding protein-3 (IGFBP-3). Results The results of the present study confirmed the induction of systemic anaphylaxis in mice through the elevated mast cell mediators in the peritoneal lavage. Consequently, lung stress triggered IL-33 secretion that influenced autophagy markers; IGFBP-3, activating transcription factor-6 (ATF-6), autophagy related gene 4B (ATG4B), p62, microtubule-associated protein light chain3-II (LC3-II) as well as DNA damage-regulated autophagy modulator 1 (DRAM1). Conclusion This research is a trial to investigate lung autophagy in compound 48/80 or ovalbumin-induced systemic anaphylaxis mouse models and pay a particular attention to the role of IL-33 in lung autophagy in such models. Graphical abstract

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Histomorphometry of mast cells in the convexity of human intracranial dura mater

Cited by 5 publications

References 57 publications

Presence of mast cells in the rat pericranium – a tissue very sensitive to pain

Presence of mast cells in the rat pericranium – a tissue very sensitive to pain

Is calcitonin gene-related peptide (CGRP) the missing link in food histamine-induced migraine? A review of functional gut-to-trigeminovascular system connections

IL-33 triggers lung autophagy in anaphylaxis mice models

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