Histone Acetylation Dynamics Integrates Metabolic Activity to Regulate Plant Response to Stress

Hu, Yongfeng; Lu, Yue; Zhao, Yu; Zhou, Dao‐Xiu

doi:10.3389/fpls.2019.01236

Cited by 91 publications

(75 citation statements)

References 92 publications

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“…Histone and chromatin modifications are important epigenetic mechanisms controlling gene expression underlying growth and stress responses (Chinnusamy and Zhu, 2009; Weng et al, 2014; Lee et al, 2017). There are numerous reports which suggested the role of histone acetylation and methylation (specifically H3K4 di- and tri-methylation) in gene transcriptional activation underlying stress responses (Saleh et al, 2008; Hu et al, 2015; Hu et al, 2019; Ueda and Seki, 2020). Recently, Chen et al, 2019 showed that p300/CREB HISTONE ACETYLTRANSFERASE 1 (HAC1) in association with WRKY18/53 transcription factors regulate sugar responsive gene expression by modulation of histone acetylation (Chen et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

TOR coordinates with transcriptional and chromatin machinery to regulate thermotolerance and thermomemory

Sharma

Shukla

et al. 2020

Preprint

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Global warming exhibits profound effects on plant fitness and productivity. To withstand stress, plants sacrifice their growth and activate protective stress responses for ensuring survival. However, the switch between growth and stress is largely elusive. In the past decade, emerging role of Target of Rapamycin (TOR) has been studied linking energy and stress signaling. Here, we have identified an important role of Glc-TOR signaling in plant adaptation to heat stress (HS). We show that Glc-TOR signaling regulates thermotolerance and thermomemory response through distinct mechanisms. Glc-TOR via E2Fa signaling module governs the transcriptome reprogramming of a myriad set of genes involved in HS protection and recovery. Glc also epigenetically governs the transcription of core HS signaling genes in a TOR-dependent manner. TOR acts in concert with p300/CREB HISTONE ACETYLTRANSFERASE1 (HAC1) and dictates the epigenetic landscape of HS loci to regulate thermotolerance. Arabidopsis plants defective in TOR and HAC1 exhibited reduced thermotolerance with a decrease in expression of core HS signaling genes. TOR also promotes accumulation of histone H3K4me3 marks at the promoters of thermomemory-related genes and therefore, governs thermomemory. Further, genome-wide transcriptome of Glc-TOR shows huge overlap with targets of chromatin remodeler BRAHMA, especially with genes enriched in stress, chromatin remodelling and histone/protein modifications. Collectively, our findings thus reveal a mechanistic framework in which Glc-TOR signalling through multiple modules determines the integration of stress and energy signaling to regulate thermotolerance and thermomemory.

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Section: Resultsmentioning

confidence: 99%

TOR coordinates with transcriptional and chromatin machinery to regulate thermotolerance and thermomemory

Sharma

Shukla

et al. 2020

Preprint

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“…In plants, the activities of sirtuin HDACs are dependent on the NAD + level and NAD + /NADH ratio [21]. Thus, oxidative stress alters the redox status of NAD + , and may further imprint on HDAC activity.…”

Section: Redox Affecting Chromatin Remodelers and Other Chromatin-assmentioning

confidence: 99%

“…In recent years, many review papers covering the roles and regulatory mechanisms of epigenetic modifications have been published. The relationship between redox metabolites and some epigenetic modifications has also been discussed [8, [10][11][12][19][20][21][22]. However, the functions and mechanisms of redox mediators modulating the epigenetic modifications are not comprehensively summarized.…”

Section: Introductionmentioning

confidence: 99%

Redox Components: Key Regulators of Epigenetic Modifications in Plants

Wang

Zhang

et al. 2020

IJMS

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Epigenetic modifications including DNA methylation, histone modifications, and chromatin remodeling are crucial regulators of chromatin architecture and gene expression in plants. Their dynamics are significantly influenced by oxidants, such as reactive oxygen species (ROS) and nitric oxide (NO), and antioxidants, like pyridine nucleotides and glutathione in plants. These redox intermediates regulate the activities and expression of many enzymes involved in DNA methylation, histone methylation and acetylation, and chromatin remodeling, consequently controlling plant growth and development, and responses to diverse environmental stresses. In recent years, much progress has been made in understanding the functional mechanisms of epigenetic modifications and the roles of redox mediators in controlling gene expression in plants. However, the integrated view of the mechanisms for redox regulation of the epigenetic marks is limited. In this review, we summarize recent advances on the roles and mechanisms of redox components in regulating multiple epigenetic modifications, with a focus of the functions of ROS, NO, and multiple antioxidants in plants.

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“…This reduces the affinity of the histone tail for the DNA and contributes to release the interaction between histones and DNA, and to open the chromatin (Barnes et al, 2019). Due to its great impact on a myriad of cellular and developmental processes, the antagonistic action of two classes of enzymes, histone deacetylases (HDACs), and histone acetyltransferases (HATs), has been the subject of a growing number of studies (Liu et al, 2014;Hu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Insights Into the Function of the NuA4 Complex in Plants

et al. 2020

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Chromatin remodeling plays a key role in the establishment and maintenance of gene expression patterns essential for plant development and responses to environmental factors. Post-translational modification of histones, including acetylation, is one of the most relevant chromatin remodeling mechanisms that operate in eukaryotic cells. Histone acetylation is an evolutionarily conserved chromatin signature commonly associated with transcriptional activation. Histone acetylation levels are tightly regulated through the antagonistic activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs). In plants, different families of HATs are present, including the MYST family, which comprises homologs of the catalytic subunit of the Nucleosome Acetyltransferase of H4 (NuA4) complex in yeast. This complex mediates acetylation of histones H4, H2A, and H2A.Z, and is involved in transcriptional regulation, heterochromatin silencing, cell cycle progression, and DNA repair in yeast. In Arabidopsis and, other plant species, homologs for most of the yeast NuA4 subunits are present and although the existence of this complex has not been demonstrated yet, compelling evidence supports the notion that this type of HAT complex functions from mosses to angiosperms. Recent proteomic studies show that several Arabidopsis homologs of NuA4 components, including the assembly platform proteins and the catalytic subunit, are associated in vivo with additional members of this complex suggesting that a NuA4-like HAT complex is present in plants. Furthermore, the functional characterization of some Arabidopsis NuA4 subunits has uncovered the involvement of these proteins in the regulation of different plant biological processes. Interestingly, for most of the mutant plants deficient in subunits of this complex characterized so far, conspicuous defects in flowering time are observed, suggesting a role for NuA4 in the control of this plant developmental program. Moreover, the participation of Arabidopsis NuA4 homologs in other developmental processes, such as gametophyte development, as well as in cell proliferation and stress and hormone responses, has also been reported. In this review, we summarize the current state of knowledge on plant putative NuA4 subunits and discuss the latest progress concerning the function of this chromatin modifying complex.

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Histone Acetylation Dynamics Integrates Metabolic Activity to Regulate Plant Response to Stress

Cited by 91 publications

References 92 publications

TOR coordinates with transcriptional and chromatin machinery to regulate thermotolerance and thermomemory

TOR coordinates with transcriptional and chromatin machinery to regulate thermotolerance and thermomemory

Redox Components: Key Regulators of Epigenetic Modifications in Plants

Insights Into the Function of the NuA4 Complex in Plants

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