Histone acetyltransferase KAT2A modulates neural stem cell differentiation and proliferation by inducing degradation of the transcription factor PAX6

Dong, Zhangji; He, Wei; Guo, Lin; Chen, Xu; Cao, Sixian; Guan, Tuchen; Sun, Yu; Zhang, Yufang; Qi, Mengwei; Guo, Boling; Zhou, Zhihao; Zhuo, Run; Wu, Ronghua; Liu, Mei; Liu, Yan

doi:10.1016/j.jbc.2023.103020

Cited by 4 publications

(3 citation statements)

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“…Like KAT6A, KAT6B activates osteogenic differentiation by interacting with RUNX2 through the C‐terminal serine/methionine domains (Pelletier et al, 2002). Two other HATs, KAT2A (also known as GCN5) and KAT2B (also known as PCAF) control craniofacial chondrocyte differentiation and maturation programs through direct histone acetylation of H3K9 as well as through non‐HAT activity and indirect control of the mTORC1 pathway (Dong et al, 2023; Pezoa et al, 2020; Sen et al, 2018).…”

Section: Dual Activating and Repressing Functions Of Histone Modifica...mentioning

confidence: 99%

“…Chromatin remodeling disorders associated with craniofacial malformation (Dong et al, 2023;Pezoa et al, 2020;Sen et al, 2018) (Continues) Investigating the cell type-specific nature of specialized dual roles of DNMT3B and its accessory function is needed to determine its functions in non-neural crest tissues or whether its function in neural crest development is cell autonomous.…”

Section: Ncc Formation and Differentiationmentioning

confidence: 99%

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Epigenetic regulation of craniofacial development and disease

Shull,

Artinger

2023

Birth Defects Research

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BackgroundThe formation of the craniofacial complex relies on proper neural crest development. The gene regulatory networks (GRNs) and signaling pathways orchestrating this process have been extensively studied. These GRNs and signaling cascades are tightly regulated as alterations to any stage of neural crest development can lead to common congenital birth defects, including multiple syndromes affecting facial morphology as well as nonsyndromic facial defects, such as cleft lip with or without cleft palate. Epigenetic factors add a hierarchy to the regulation of transcriptional networks and influence the spatiotemporal activation or repression of specific gene regulatory cascades; however less is known about their exact mechanisms in controlling precise gene regulation.AimsIn this review, we discuss the role of epigenetic factors during neural crest development, specifically during craniofacial development and how compromised activities of these regulators contribute to congenital defects that affect the craniofacial complex.

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Section: Dual Activating and Repressing Functions Of Histone Modifica...mentioning

confidence: 99%

Section: Ncc Formation and Differentiationmentioning

confidence: 99%

Epigenetic regulation of craniofacial development and disease

Shull,

Artinger

2023

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…Recently, Dong et al . uncovered a novel posttranslational regulatory mechanism that reduces Pax6 protein levels in NSCs ( 7 ). The central player in this new pathway is the histone acetyltransferase Kat2a (aka Gcn5; general control nonrepressed protein 5) known to promote transcription through chromatin remodeling ( 8 ).…”

mentioning

confidence: 99%