Histone deacetylase  A potential therapeutic target for ovarian dysfunction

Sunita, Sunita; Singh, Pankaj Kumar; Onteru, Suneel Kumar; Singh, Dheer

doi:10.2741/4603

Cited by 4 publications

(1 citation statement)

References 126 publications

(166 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As far as benign gynecological health conditions are concerned, Olaniyi et al have, for instance, suggested that the short chain fatty acid acetate successfully restores the ovarian function in experimentally induced polycystic ovarian syndrome (PCOS) rat models [77]. In addition, Sunita et al concluded that HDACIs embody effective therapeutic agents against infertility through the efficient restoration of normal reproductive mechanisms [78]. The present review of the literature, to our knowledge, constitutes the most comprehensive, up-to-date review article on the impact of histone modifications and their therapeutic targeting in endometriosis, a benign gynecological health disease which negatively affects the quality of life of many women worldwide.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities

Psilopatis

Vrettou

Fleckenstein

et al. 2023

Cells

View full text Add to dashboard Cite

Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the particular role of HDACs and their inhibitors in the context of endometriosis. HDAC1, HDAC2, HDAC3, Sirtuin 1, and Sirtuin 3, are the five most studied HDAC enzymes which seem to, at least partly, influence the pathophysiology of endometriosis. Both well-established and novel HDACIs could possibly represent modern, efficacious anti-endometriotic drug agents. Altogether, histone modifications and their therapeutic targeting have been proven to have a strong impact on endometriosis.

show abstract

Section: Discussionmentioning

confidence: 99%

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities

Psilopatis

Vrettou

Fleckenstein

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise

Chelucci,

Scarfò,

Piccarducci

et al. 2024

J Mol Neurosci

View full text Add to dashboard Cite

Physical activity has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseases (NDs). Biological responses to physical activity and vulnerabilities to NDs are emerging to be gender-related. Herein, known ND-associated markers (β-amyloid, tau, α-synuclein), main sex steroid hormones, antioxidant responses, and key gene transcription modulators were evaluated in the blood of physically active and sedentary women and men. In our hands, females presented higher basal erythrocytes β-amyloid and α-synuclein amounts than males. Regular physical activity was able to significantly reduce the erythrocyte content of β-amyloid in females and the tau levels in males, suggesting that these differences may be mediated by organizational actions of sex steroid hormones during development. Furthermore, despite a comparable plasma antioxidant capability (AOC) between males and females, in the latter group, physical activity significantly enhances AOC versus peroxynitrite radicals only. Finally, regular physical activity modulated the levels of transcription factor Nrf2 in erythrocytes, as well as the plasma concentration of the microRNA miR-195 and miR-153, suggesting the promotion of antioxidant/autophagic processes associated with ND-related proteins. Overall, these results could shed light on how cerebral adaptations to physical activity differ between males and females, especially with regard to blood accumulation of ND proteins and mechanisms of antioxidant responses to regular exercise.

show abstract

Sex differences in blood accumulation of neurodegenerative-related proteins and antioxidant responses to regular physical exercise

Chelucci,

Scarfò,

Piccarducci

et al. 2024

Preprint

View full text Add to dashboard Cite

Physical activity (PA) has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseases (NDs). Biological responses to PA and vulnerabilities to NDs are emerging to be gender-related. Herein, known ND-associated markers (β-amyloid, tau, α-synuclein), main sex steroid hormones, antioxidant responses, and key gene transcription modulators were evaluated in the blood of physically active and sedentary women and men. In our hands, females presented higher basal erythrocytes β-amyloid and α-synuclein amounts than males. Regular PA was able to significantly reduce the erythrocytes content of β-amyloid in females and the tau levels in males, suggesting that these differences may be mediated by organizational actions of sex steroid hormones during development. Furthermore, despite a comparable plasma antioxidant capability (AOC) between males and females, in the latter group PA significantly enhance AOC versus peroxynitrite radicals only. Finally, regular PA modulated the levels of transcription factor Nrf2 in erythrocytes, as well as the plasma concentration of the microRNA miR-195, miR-153, suggesting promotion of antioxidant/autophagic processes associated to ND-related proteins. Overall, these results could shed light on how cerebral adaptations to PA differs between males and females, especially with regard to blood accumulation of ND-proteins and mechanisms of antioxidant responses to regular exercise.

show abstract

Histone deacetylase A potential therapeutic target for ovarian dysfunction

Cited by 4 publications

References 126 publications

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities

Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise

Sex differences in blood accumulation of neurodegenerative-related proteins and antioxidant responses to regular physical exercise

Contact Info

Product

Resources

About