Histone deacetylase inhibitor potentiates chemotherapy-induced apoptosis through Bim upregulation in Burkitt’s lymphoma cells

Abstract

The study provides strong evidence for the synergistic effects of the association with HDCI and chemotherapy in BL cells.

Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration

“…However, few studies, so far, have suggested cross-talk between FOXO signaling and Rho expression. Previously, we found that HDACi potentiate chemotherapy-induced apoptosis via the up-regulation of Bim [12], a transcriptional target of FOXO3 [56].…”

“…To improve the BL treatment response in specific groups of patients, further understanding of the molecular biology of this disease is necessary. Our group has shown the promising potential of a combination therapy consisting of an HDACi and chemotherapy for BL cells [12]. We observed a synergistic effect of the sodium butyrate/etoposide combination and noted the involvement of PI3K signaling in the treatment response [7].…”

“…Western blot analysis was performed as described previously [12]. The anti-RhoB, -RhoC, and -Cdc42 antibodies were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA).…”

Quantitative analysis of CDKN2A methylation, mRNA, and p16INK4a protein expression in children and adolescents with Burkitt lymphoma: Biological and clinical implications

“…Although single epigenetic agents have limited activity, the combination of epigenetic drugs, or epigenetic agent with chemotherapy have been synergistically effective in inducing apoptosis and growth inhibition in B-cell lymphomas [41,54,55]. Therefore, these novel approaches should improve treatment strategies to circumvent unresponsive BL patients in the future.…”

Current understanding of the role and regulation of miRNAs in Burkitt lymphoma

“…Treatment with the combination of histone deacetylase inhibitor and chemotherapy results in induction of apoptosis in BL cells through the proapoptotic BCL2-related family member Bim protein 104. A recent study of the same group describes that the use of combination of histone deacetylase inhibitor and chemotherapy could prevent cell growth in BL by regulating PI3K/Akt, suggesting that other targets, such as the PI3K/Akt signaling network, in addition to MYC should be further explored 105.…”