Histone deacetylase inhibitors in medical therapeutics

Chun, Pusoon

doi:10.1016/b978-0-12-823928-5.00029-3

Cited by 2 publications

(3 citation statements)

References 291 publications

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“…In fact, HDAC inhibition regulates intrinsic and non-intrinsic apoptotic pathways through the induction of proapoptotic genes . Many studies have showed that HDAC inhibitors prevent cancer cell proliferation by inducing cell cycle arrest at the G0/G1 and/or G2/M phases . We also observe that safranal leads to G0/G1 and G2/M arrest in our cell cycle arrest analysis (Figure B) and acted similar to trichostatin A, a famous HDAC inhibitor in hepatoma cells.…”

Section: Resultssupporting

confidence: 72%

“…116 Many studies have showed that HDAC inhibitors prevent cancer cell proliferation by inducing cell cycle arrest at the G0/G1 and/or G2/M phases. 117 We also observe that safranal leads to G0/G1 and G2/M arrest in our cell cycle arrest analysis (Figure 5B) and acted similar to trichostatin A, a famous HDAC inhibitor in hepatoma cells. Trichostatin A also induces the accumulation of acetylated histones H3 and G0/G1 arrest.…”

Section: Modulation Of Phosphorylation On Histone Acetyltransferases ...supporting

confidence: 65%

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Quantitative Phosphoproteomics and Acetylomics of Safranal Anticancer Effects in Triple-Negative Breast Cancer Cells

et al. 2022

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Safranal, as an aroma in saffron, is one of the cytotoxic compounds in saffron that causes cell death in triplenegative breast cancer cells. Our recent research reported the anticancer effects of safranal, which further demonstrated its impact on protein translation, mitochondrial dysfunction, and DNA fragmentation. To better understand the underlying mechanisms, we identified acetylated and phosphorylated peptides in safranaltreated cancer cells. We conducted a comprehensive phosphoproteomics and acetylomics analysis of safranal-treated MDA-MB-231 cells by using a combination of TMT labeling and enrichment methods including titanium dioxide and immunoprecipitation. We provide a wide range of phosphoproteome regulation in different signaling pathways that are disrupted by safranal treatment. Safranal influences the phosphorylation level on proteins involved in DNA replication and repair, translation, and EGFR activation/ accumulation, which can lead the cells into apoptosis. Safranal causes DNA damage which is followed by the activation of cell cycle checkpoints for DNA repair. Over time, checkpoints and DNA repair are inhibited and cells are under a mitotic catastrophe. Moreover, safranal prevents repair by the hypo-acetylation of H4 and facilitates the transcription of proapoptotic genes by hyperacetylation of H3, which push the cells to the brink of death.

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Section: Resultssupporting

confidence: 72%

Section: Modulation Of Phosphorylation On Histone Acetyltransferases ...supporting

confidence: 65%

Quantitative Phosphoproteomics and Acetylomics of Safranal Anticancer Effects in Triple-Negative Breast Cancer Cells

et al. 2022

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“…An epidrug Panobinostat, a non-selective histone deacetylase inhibitor, has been approved by the U.S. F.D.A. for the treatment of multiple myeloma [60].…”

Section: Effects Of Epigenetics On Human Healthmentioning

confidence: 99%

Epigenetics: Science of Changes without Change in DNA Sequences

Dhargawe¹,

Lakkakul²,

Hirapure³

2024

Modifications in Biomacromolecules

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The mechanisms for epigenetic modifications include modification of histone proteins or modifications of the DNA itself (not affecting the DNA sequence). These include acetylation, methylation, phosphorylation, SUMOylation, ubiquitylation, etc. For example, DNA methylation (cytosine methylation) or histone acetylation (lysine acetylation). Recent studies have indicated that the activity of non-coding RNAs, such as microRNAs, long non-coding RNAs, and small interfering RNAs also affects epigenetic mechanisms. In a genome, the collection of all the modifications that regulate gene expression is called its epigenome. Improper occurrence of the epigenetic mechanisms can lead to deleterious health and behavioral effects. For instance, the most studied epigenetic modification is DNA hypermethylation, which leads to the silencing of antitumorigenic genes, and this has been shown to cause cancer. Various techniques are employed for DNA methylation profiling such as pyrosequencing, bisulfite-PCR, ChIP seq (Chromatin Immunoprecipitation), bisulfite seq, and specialized RNA seq. This chapter will introduce epigenetics, describe the different epigenetic mechanisms, and discuss in brief how to study these mechanisms and their effects on the plant as well as human health.

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Histone deacetylase inhibitors in medical therapeutics

Cited by 2 publications

References 291 publications

Quantitative Phosphoproteomics and Acetylomics of Safranal Anticancer Effects in Triple-Negative Breast Cancer Cells

Quantitative Phosphoproteomics and Acetylomics of Safranal Anticancer Effects in Triple-Negative Breast Cancer Cells

Epigenetics: Science of Changes without Change in DNA Sequences

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