Histone demethylase KDM4A and KDM4B expression in granulosa cells from women undergoing in vitro fertilization

Krieg, Adam J.; Mullinax, Sarah R.; Grimstad, Frances; Marquis, Kaitlin M.; Constance, E.S.; Yu, Hong; Krieg, Sacha A.; Roby, Katherine F.

doi:10.1007/s10815-018-1151-3

Cited by 10 publications

(7 citation statements)

References 80 publications

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“…The raw genomic sequencing data from this work have been uploaded to the NCBI SRA database with accession number PRJNA560632 ( ). The variation data reported in this paper has been deposited in the Genome Variation Map [ 56 ] in National Genomics Data Center [ 57 ], China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences, under accession number GVM000114 at .…”

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confidence: 99%

Whole Genome Sequencing Reveals the Effects of Recent Artificial Selection on Litter Size of Bamei Mutton Sheep

Yao

Pan

et al. 2021

Animals

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Bamei mutton sheep is a Chinese domestic sheep breed developed by crossing German Mutton Merino sheep and indigenous Mongolian sheep for meat production. Here, we focused on detecting candidate genes associated with the increasing of the litter size in this breeds under recent artificial selection to improve the efficiency of mutton production. We selected five high- and five low-fecundity Bamei mutton sheep for whole-genome resequencing to identify candidate genes for sheep prolificacy. We used the FST and XP-EHH statistical approach to detect the selective sweeps between these two groups. Combining the two selective sweep methods, the reproduction-related genes JUN, ITPR3, PLCB2, HERC5, and KDM4B were detected. JUN, ITPR3, and PLCB2 play vital roles in GnRH (gonadotropin-releasing hormone), oxytocin, and estrogen signaling pathway. Moreover, KDM4B, which had the highest FST value, exhibits demethylase activity. It can affect reproduction by binding the promoters of estrogen-regulated genes, such as FOXA1 (forkhead box A1) and ESR1 (estrogen receptor 1). Notably, one nonsynonymous mutation (p.S936A) specific to the high-prolificacy group was identified at the TUDOR domain of KDM4B. These observations provide a new opportunity to research the genetic variation influencing fecundity traits within a population evolving under artificial selection. The identified genomic regions that are responsible for litter size can in turn be used for further selection.

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confidence: 99%

Whole Genome Sequencing Reveals the Effects of Recent Artificial Selection on Litter Size of Bamei Mutton Sheep

Yao

Pan

et al. 2021

Animals

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“…In the developing ovarian follicle, granulosa cells are the main producers of estrogen. KDM4B is expressed in granulosa cells at early stages of folliculogenesis and its level is correlated with pregnancy failure in IVF patients (40). KDM4B expression in the uterus is also associated with recurrent pregnancy loss in women (41).…”

Section: Discussionmentioning

confidence: 99%

Whole-Genome Sequencing of Bamei Mutton Sheep for Screening the Genes and SNPs Associated with Litter Size under Selection

Yao

Pan

et al. 2020

Preprint

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Background: Bamei mutton sheep is a Chinese domestic sheep breed developed by crossing German Mutton Merino sheep and indigenous Mongolian sheep for meat production. Here, we focused on increasing the litter size of this breed to improve the efficiency of mutton production.Results: We selected five high- and five low-fecundity Bamei mutton sheep for whole-genome resequencing to identify candidate genes for sheep prolificacy. We used the FST and XP-EHH statistical approach to detect the selective sweeps between these two groups. Combining the two selective sweep methods, the reproduction-related genes JUN, ITPR3, PLCB2, HERC5, and KDM4B were detected. JUN, ITPR3, and PLCB2 play vital roles in GnRH, oxytocin, and estrogen signaling pathway. Moreover, KDM4B, which had the highest FST value, exhibits demethylase activity. It can affect reproduction by binding the promoters of estrogen-regulated genes, such as FOXA1 and ESR1. Notably, one nonsynonymous mutation (p.S936A) specific to the high-prolificacy group was identified at the TUDOR domain of KDM4B.Conclusion: These observations provide a new opportunity to research the genetic variation influencing fecundity traits within a population evolving under artificial selection. The identified genomic regions of KDM4B that are responsible for litter size can in turn be used for further selection.

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“…KDM4A and KDM4B are located in human oocytes, granulosa cells, theca cells, and luteal cells in reproductive-aged women ( Krieg et al, 2018 ). Deletion of KDM4A during oogenesis had no significant impact on ovulation since KDM4A –/– and wild-type females ovulated similar numbers of fertilizable oocytes.…”

Section: Epigenetic Modification Involved Systematically In Oocytes Dmentioning

confidence: 99%

Mechanisms of Oocyte Maturation and Related Epigenetic Regulation

Zhang

Yang

et al. 2021

Front. Cell Dev. Biol.

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Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins-induced ovulation happens. Once meiosis gets started, the oocytes undergo the leptotene, zygotene, and pachytene stages, and then arrest at the dictyate stage. During each estrus cycle in mammals, or menstrual cycle in humans, a small portion of oocytes within preovulatory follicles may resume meiosis. It is crucial for females to supply high quality mature oocytes for sustaining fertility, which is generally achieved by fine-tuning oocyte meiotic arrest and resumption progression. Anything that disturbs the process may result in failure of oogenesis and seriously affect both the fertility and the health of females. Therefore, uncovering the regulatory network of oocyte meiosis progression illuminates not only how the foundations of mammalian reproduction are laid, but how mis-regulation of these steps result in infertility. In order to provide an overview of the recently uncovered cellular and molecular mechanism during oocyte maturation, especially epigenetic modification, the progress of the regulatory network of oocyte meiosis progression including meiosis arrest and meiosis resumption induced by gonadotropins is summarized. Then, advances in the epigenetic aspects, such as histone acetylation, phosphorylation, methylation, glycosylation, ubiquitination, and SUMOylation related to the quality of oocyte maturation are reviewed.

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Histone demethylase KDM4A and KDM4B expression in granulosa cells from women undergoing in vitro fertilization

Cited by 10 publications

References 80 publications

Whole Genome Sequencing Reveals the Effects of Recent Artificial Selection on Litter Size of Bamei Mutton Sheep

Whole Genome Sequencing Reveals the Effects of Recent Artificial Selection on Litter Size of Bamei Mutton Sheep

Whole-Genome Sequencing of Bamei Mutton Sheep for Screening the Genes and SNPs Associated with Litter Size under Selection

Mechanisms of Oocyte Maturation and Related Epigenetic Regulation

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