2020
DOI: 10.1101/2020.11.28.402172
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Histone H1 protects telomeric repeats from H3K27me3 invasion inArabidopsis

Abstract: Linker histones play a pivotal role in shaping chromatin architecture, notably through their globular H1 (GH1) domain that contacts the nucleosome and linker DNA. Yet, the interplay of H1 with chromatin factors along the epigenome landscape is poorly understood. Here, we report that Arabidopsis H1 favors chromatin compaction and H3K27me3 marking on a majority of Polycomb-targeted protein-coding genes while preventing H3K27me3 accumulation on telomeres and pericentromeric interstitial telomeric repeats (ITRs). … Show more

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Cited by 14 publications
(21 citation statements)
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References 152 publications
(473 reference statements)
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“…D) Telo -box motifs recruit Polycomb repressive complexes (PRC2) via interactions of PRC2 subunits with TRB (Zhou et al 2016; Zhou et al 2018, this study) CLF, CURLY LEAF; SWN, SWINGER; EMF2, EMBRYONIC FLOWER 2; VRN2, VERNALIZATION 2. E) Histone H1 prevents the invasion of H3K27me3 and TRB1 over telomeres and long interstitial telomeric regions (Teano et al 2020). F) TRB proteins, as subunits of the PEAT (PWO-EPCR-ARID-TRB) complex, are involved in heterochromatin formation and gene repression, but also have a locus-specific activating role, possibly through the promotion of histone acetylation (Tan et al 2018; Tsuzuki and Wierzbicki 2018; Mikulski et al 2019).…”
Section: Resultsmentioning
confidence: 99%
“…D) Telo -box motifs recruit Polycomb repressive complexes (PRC2) via interactions of PRC2 subunits with TRB (Zhou et al 2016; Zhou et al 2018, this study) CLF, CURLY LEAF; SWN, SWINGER; EMF2, EMBRYONIC FLOWER 2; VRN2, VERNALIZATION 2. E) Histone H1 prevents the invasion of H3K27me3 and TRB1 over telomeres and long interstitial telomeric regions (Teano et al 2020). F) TRB proteins, as subunits of the PEAT (PWO-EPCR-ARID-TRB) complex, are involved in heterochromatin formation and gene repression, but also have a locus-specific activating role, possibly through the promotion of histone acetylation (Tan et al 2018; Tsuzuki and Wierzbicki 2018; Mikulski et al 2019).…”
Section: Resultsmentioning
confidence: 99%
“…Several non-exclusive mechanisms can be envisaged, including changes in PRC2 catalytic activity or its genomic targeting. Dual H3K9me and H3K27me activities of E(z)-like proteins in ciliates [ 106 ], DNA methylation and/or H3K9me preventing H3K27me3 targeting to TEs in various eukaryotes [ 49 ] and recently reported prevention of H3K27me3 targeting to telomeric sequences by histone H1 in A. thaliana [ 307 ] may provide important hints.…”
Section: Emerging Patterns and Questions In Prc2 Evolutionmentioning
confidence: 99%
“…H1 is further involved in H3K27me3 homeostasis [46,47], as H1 favors H3K27me3 enrichment at Polycomb-regulated genes and prevents over-accumulation of H3K27me3 at interstitial telomeric repeats [47].…”
Section: Specific Roles For Histone Variants In Somatic Cellsmentioning
confidence: 99%
“…H3K27me3 plays a central role in gene expression control during development [48][49][50] and a common function of several histone variants seems to be the regulation of this repressive mark not only by ensuring maintenance at the replication fork [16,43] or preventing redistribution along the genome [46,47] but also by facilitating rapid H3K27me3 reprogramming [51,52]. An example for the latter is incorporation of the atypical histone variant H3.15 that lacks lysine 27 (Figure 1) and is induced upon wounding in roots.…”
Section: Specific Roles For Histone Variants In H3k27me3 Reprogrammin...mentioning
confidence: 99%