Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Schneider, Robert; Bannister, Andrew J.; Myers, Fiona A.; Thorne, Alan W.; Crane‐Robinson, Colyn; Kouzarides, Tony

doi:10.1038/ncb1076

Cited by 701 publications

(634 citation statements)

References 22 publications

Supporting

Mentioning

556

Contrasting

Unclassified

Order By: Relevance

“…Thereby, the changes in the H3K27me2 and H3K4me3 methylation profiles of the WRKY70 nucleosomes were consistent with patterns known to accompany transcriptional activation. 13,27 However, H3K9me2 modification appeared not to be involved in regulating WRKY70 expression.…”

Section: Resultsmentioning

confidence: 99%

Epigenetic Control of a Transcription Factor at the Cross Section of Two Antagonistic Pathways

Álvarez-Venegas¹,

Al‐Abdallat²,

Guo³

et al. 2007

Epigenetics

152

109

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Epigenetic Control of a Transcription Factor at the Cross Section of Two Antagonistic Pathways

Álvarez-Venegas¹,

Al‐Abdallat²,

Guo³

et al. 2007

Epigenetics

152

109

View full text Add to dashboard Cite

“…For instance, active transcriptional enhancers contain relatively high levels of H3K4me1, a reliable predictive feature [89]. However, active genes themselves possess a high enrichment of H3K4me3, which marks the transcriptional start site (TSS) [86,90]. In addition, H3K36me3 is highly enriched throughout the entire transcribed region [91].…”

Section: Euchromatinmentioning

confidence: 99%

Regulation of chromatin by histone modifications

2011

Self Cite

View full text Add to dashboard Cite

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a key role in this regulation is the modification of histones. There is an ever-growing list of these modifications and the complexity of their action is only just beginning to be understood. However, it is clear that histone modifications play fundamental roles in most biological processes that are involved in the manipulation and expression of DNA. Here, we describe the known histone modifications, define where they are found genomically and discuss some of their functional consequences, concentrating mostly on transcription where the majority of characterisation has taken place.

show abstract

“…H3 K36 dimethylation is primarily localized to the transcribed regions of genes and is created by the histone methyltransferase Suvar39 enhancer of zeste trithorax (SET2), which is recruited by RNA polymerase II during transcription elongation (32,33). To determine a possible role of a SET2-like factor in this system, ChIP analysis was performed in 1-kb increments downstream of the HLA-DRA promoter using Abs to H3 dimethyl K36 in both Raji and RJ2.2.5 cells (Fig.…”

Section: Histone H3 K36 Dimethylation Is Associated With the Hla-dra mentioning

confidence: 99%

“…Histone H3 K4 trimethylation is one of the few histone modifications that is clearly associated with transcriptionally active genes (32,33). ChIP analysis for this mark was performed as above (Fig.…”

Section: Trimethylation Of Histone H3 At Lysine 4 Is Restrictedmentioning

confidence: 99%

X Box-Like Sequences in the MHC Class II Region Maintain Regulatory Function

Gómez

Majumder

Nagarajan

et al. 2005

The Journal of Immunology

View full text Add to dashboard Cite

Sequences homologous to the canonical MHC class II (MHC-II) gene X box regulatory elements were identified within the HLA-DR subregion of the human MHC and termed X box-like (XL) sequences. Several XL box sequences were found to bind the MHC class II-specific transcription factors regulatory factor X and CIITA and were transcriptionally active. The histone code associated with the XL boxes and that of the HLA-DRA X box was determined. Using CIITA-positive and -negative B cell lines, CIITA-specific histone modifications were identified and found to be consistent among the active XL boxes. Although a remarkable similarity was observed for most modifications, differences in magnitude between the HLA-DRA promoter for modifications associated with the assembly of the general transcription factors, such as histone H3 lysine 9 acetylation and H3 lysine 4 trimethylation, distinguished the very active HLA-DRA promoter from the XL box regions. In response to IFN-γ, XL box-containing histones displayed increased acetylation, coincident with CIITA expression and that observed in B cells, suggesting that the end point mechanisms of chromatin remodeling for cell type-specific MHC-II expression were similar. Lastly, an interaction between one XL box and the HLA-DRA promoter was observed in a chromatin-looping assay. Therefore, these data provide evidence that certain XL box sequences contribute to a global increase in chromatin accessibility of the HLA-DR region in B lymphocytes and in response to IFN-γ and supports the involvement of these XL sequences in the regulation of MHC-II genes.

show abstract

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Cited by 701 publications

References 22 publications

Epigenetic Control of a Transcription Factor at the Cross Section of Two Antagonistic Pathways

Epigenetic Control of a Transcription Factor at the Cross Section of Two Antagonistic Pathways

Regulation of chromatin by histone modifications

X Box-Like Sequences in the MHC Class II Region Maintain Regulatory Function

Contact Info

Product

Resources

About