Histone H3 Phosphorylation in Plants and Other Organisms

Moraes, Izabel Cristina Freitas; Casas-Mollano, J. Armando

doi:10.1007/978-3-319-07971-4_4

Cited by 1 publication

(2 citation statements)

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“…Indeed, mlk quadruple mutant is lethal [16,60], supporting the vital nature of MLKs in Arabidopsis. The role of the canonical plant CK1 in phosphorylation-dependent regulation of chromatin and cell cycle has been reviewed [43,46,49]. We described, here, the recent findings on the functions of plant CK1, especially MLK family members in light signaling, circadian rhythm, phytohormone and stress response.…”

Section: Biological Functions Of Plant Ck1mentioning

confidence: 96%

“…Identification of upstream kinases and the target site(s) of individual enzyme is complicated due to the fact that there are numerous candidate kinases responsible for histone phosphorylation and that multiple sites of plant histones are potential phosphorylation targets. In plants, histone phosphorylation modulated by the canonical kinases, such as AtAurora3 and AtHaspin, has been recently reviewed [43,46,49]. In vitro assay showed that Chlamydomonus Mut9p and Arabidopsis MLK1 and MLK4 phosphorylated histones including H3, H2A and H4, albeit at different intensity [14,22,37].…”

Section: Histones Targeted By Mlk Famliy Membersmentioning

confidence: 99%

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Mut9p-LIKE KINASE Family Members: New Roles of the Plant-Specific Casein Kinase I in Plant Growth and Development

Wang

2020

IJMS

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Casein kinase I (CK1), a ubiquitous serine/threonine (Ser/Thr) protein kinase in eukaryotes, plays pivotal roles in a wide spectrum of cellular functions including metabolism, cell cycle progression, developmental control and stress response. Plant CK1 evolves a lineage expansion, resulting in a unique branch of members exclusive to the kingdom. Among them, Arabidopsis Mut9p-LIKE KINASEs (MLKs) target diverse substrates including histones and the key regulatory proteins involving in physiological processes of light signaling, circadian rhythms, phytohormone and plant defense. Deregulation of the kinase activity by mutating the enzyme or the phosphorylation sites of substrates causes developmental disorders and susceptibility to adverse environmental conditions. Recent findings suggest that MLKs have evolved as a general kinase that modifies transcription factors or primary regulatory proteins in a dynamic way. Here, we summarize the current knowledge of the roles of MLKs and MLK orthologs in several commercially important crops.

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