Histone Kinases and Phosphatases

Watson, Nikolaus A.; Higgins, Jonathan M.G.

doi:10.1016/b978-0-12-802389-1.00004-6

Cited by 4 publications

(2 citation statements)

References 152 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histone phosphorylation for the first time discovered in 1967 (Gutierrez & Hnilica, 1967). Phosphate has negative charges thereby producing repulsion between histone and wrapped DNA consequently opening the nucleosome for transcriptional machinery (Watson & Higgins, 2016). Histone phosphorylation is mainly involved in DNA repair, transcription regulation, chromatin remodeling, apoptotic responses (Cao & Dang, 2018).…”

Section: Histone Phosphorylationmentioning

confidence: 99%

Epigenetic modifications and its basic mechanism

Bhattarai¹,

Maharjan²,

Acharya³

et al. 2021

Journal of Innovative Agriculture

View full text Add to dashboard Cite

Heritable changes in the plant's phenotype are attributed to genomic sequence change and also by epigenetic variations. These epigenetic variations are involved in controlling plants' developmental processes. Intense and close breeding has reduced the genetic variations in crop increasing their susceptibility to the changing environment. Epigenetic diversity has now emerged as a new source of variation for coping with changing environmental stresses in plants. Epigenetic modifications like DNA methylation, post-translational histone modifications, histone variants, and involvement of non-coding RNAs have played a major role in gene expression and regulation in plants. These epigenetic modifications have created the variability in phenotypic expression by selective turning on and turning off of the genomic sequence. These variabilities are created in plants in response to the environmental factors to which plants are exposed. These phenotypic variations accumulated by epigenetic modification are transferred and expressed in the next generation as they are heritable. DNA methylation and methylation of histone tails on the lysine 4, 9, and 27 positions are among the best-characterized epigenetic marks observed in both plants and animals. These modifications marks have altered the physical state of the DNA. The alternation in the physical state of DNA has changed the way cell reads the genes. This is the potential new area of the research as it creates phenotypic variability in response to stress factors without changing the chemical properties of the DNA. In this paper, we have presented the epigenetic modifications and the way they controlled the gene expression in plants and animals.

show abstract

Section: Histone Phosphorylationmentioning

confidence: 99%

Epigenetic modifications and its basic mechanism

Bhattarai¹,

Maharjan²,

Acharya³

et al. 2021

Journal of Innovative Agriculture

View full text Add to dashboard Cite

show abstract

“…A hiszton módosító enzimek elsősorban a "core" hiszton fehérjék farki részének poszt-transzlációs módosítását végzik, leggyakrabban acetil csoport hozzáadásával (HAThiszton acetiltranszferáz) és eltávolításával (HDAC -hiszton deacetiláz), metilációval (HMT -hiszton metiltranszferáz) és eltávolításával (HDM -hiszton demetiláz), vagy foszforilációval (HK -hiszton kináz) és eltávolításával (HP -hiszton foszfatáz) (2. ábra) [15][16][17] .…”

Section: Hiszton Módosítások Kromatin Remodeling éS Hiszton Variánsokunclassified

Epigenetikai módosítások hatásának és a cirkadián ritmus zavarának vizsgálata a Huntington-kór Drosophila modelljében

Faragó

View full text Add to dashboard Cite

Advances and Opportunities in Epigenetic Chemical Biology

2020

View full text Add to dashboard Cite

The study of epigenetics has greatly benefited from the development and application of various chemical biology approaches. In this review, we highlight the key targets for modulation and recent methods developed to enact such modulation. We discuss various chemical biology techniques to study DNA methylation and the post-translational modification of histones as well as their effect on gene expression. Additionally , we address the wealth of protein synthesis approaches to yield histones and nucleosomes bearing epigenetic modifications. Throughout, we highlight targets that present opportunities for the chemical biology community, as well as exciting new approaches that will provide additional insight into the roles of epigenetic marks.

show abstract

Histone Kinases and Phosphatases

Cited by 4 publications

References 152 publications

Epigenetic modifications and its basic mechanism

Epigenetic modifications and its basic mechanism

Epigenetikai módosítások hatásának és a cirkadián ritmus zavarának vizsgálata a Huntington-kór Drosophila modelljében

Advances and Opportunities in Epigenetic Chemical Biology

Contact Info

Product

Resources

About