Histone lysine demethylases as targets for anticancer therapy

Højfeldt, Jonas W.; Agger, Karl; Helin, Kristian

doi:10.1038/nrd4154

Cited by 415 publications

(339 citation statements)

References 178 publications

Supporting

Mentioning

331

Contrasting

Unclassified

Order By: Relevance

“…The ATL-specific coherent relationship comprising the epigenetic "writer" and "eraser" may contribute to locking or stabilizing the epigenetic states. 58 We also approached the regulatory mechanisms of EZH2 abundance and genomic occupancy. A series of experiments in normal T cells and in ATL models demonstrated the necessity of a complicated signaling network for sufficient EZH2 induction.…”

Section: Discussionmentioning

confidence: 99%

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Fujikawa¹,

Nakagawa²,

Hori³

et al. 2016

Blood

135

129

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Fujikawa¹,

Nakagawa²,

Hori³

et al. 2016

Blood

135

129

View full text Add to dashboard Cite

show abstract

“…This is largely due to the requirement for chromatin to be reorganized to create access to key differentiation loci. The opening of chromatin is aided by the recruitment of histone acetyl transferases (HATs), chromatin remodelling enzymes and histone methyltransferases (HMTs), as well as the recently discovered histone lysine demethylases (KDMs) and ten-eleven translocation (TET; also known as methylcytosine dioxygenase) proteins that initiate DNA demethylation [130][131][132][133][134][135][136] (FIG. 5b).…”

Section: Dna Accessibility By Modification Of Dna and Histonesmentioning

confidence: 99%

Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease

2016

View full text Add to dashboard Cite

| CD4 + T cells differentiate and acquire distinct functions to combat specific pathogens but can also adapt their functions in response to changing circumstances. Although this phenotypic plasticity can be potentially deleterious, driving immune pathology, it also provides important benefits that have led to its evolutionary preservation. Here, we review CD4 + T cell plasticity by examining the molecular mechanisms that regulate it -from the extracellular cues that initiate and drive cells towards varying phenotypes, to the cytosolic signalling cascades that decipher these cues and transmit them into the cell and to the nucleus, where these signals imprint specific gene expression programmes. By understanding how this functional flexibility is achieved, we may open doors to new therapeutic approaches that harness this property of T cells.

show abstract

“…In contrast, inhibition of histone demethylases would shift the balance between methylation and demethylation towards higher methylated histones. Histone (de)methylating enzymes are also specific, with several dozen specimens in several families described to date (reviewed in Højfeldt et al, 2013). So far, however, there are no reports of active demethylation processes in insects.…”

Section: Pharmaceutical Manipulation Of Global Histone Modificationsmentioning

confidence: 99%

Epigenetics and locust life phase transitions

Ernst

Hiel

Depuydt

et al. 2015

Journal of Experimental Biology

View full text Add to dashboard Cite

Insects are one of the most successful classes on Earth, reflected in an enormous species richness and diversity. Arguably, this success is partly due to the high degree to which polyphenism, where one genotype gives rise to more than one phenotype, is exploited by many of its species. In social insects, for instance, larval diet influences the development into distinct castes; and locust polyphenism has tricked researchers for years into believing that the drastically different solitarious and gregarious phases might be different species. Solitarious locusts behave much as common grasshoppers. However, they are notorious for forming vast, devastating swarms upon crowding. These gregarious animals are shorter lived, less fecund and transmit their phase characteristics to their offspring. The behavioural gregarisation occurs within hours, yet the full display of gregarious characters takes several generations, as does the reversal to the solitarious phase. Hormones, neuropeptides and neurotransmitters influence some of the phase traits; however, none of the suggested mechanisms can account for all the observed differences, notably imprinting effects on longevity and fecundity. This is why, more recently, epigenetics has caught the interest of the polyphenism field. Accumulating evidence points towards a role for epigenetic regulation in locust phase polyphenism. This is corroborated in the economically important locust species Locusta migratoria and Schistocerca gregaria. Here, we review the key elements involved in phase transition in locusts and possible epigenetic regulation. We discuss the relative role of DNA methylation, histone modification and small RNA molecules, and suggest future research directions. KEY WORDS: Locust phase, Polyphenism, Locust swarming, Locusta migratoria, Schistocerca gregaria, Apis mellifera, Invertebrate, DNA methylation, Histone modification, Methylome IntroductionThe term epigenetics tends to take a variety of meanings (Haig, 2004;Jablonka and Lamb, 2002). In its narrow sense, it can be defined as 'meiotically and mitotically heritable changes in gene expression, not based on DNA sequence alterations ' (Riggs et al., 1996). In a broader sense, it can also be interpreted as 'modifications of chromosome structure ' (Bird, 2007). Independent of the interpretation, however, epigenetics did not receive much attention in insect research until recent years.The most prominent epigenetic mechanisms, namely (1) methylation of cytosine in DNA, (2) modifications of histone proteins and (3) nucleosome positioning and regulation by noncoding RNA, were only rarely the focus of the entomology field. This may have been due to the general low, often almost undetectable, levels of methylation in insects and other invertebrates REVIEW Functional Genomics and Proteomics Lab, KU Leuven, Naamsestraat 59, bus 2465, B-3000 Leuven, Belgium.*Author for correspondence (Liliane.Schoofs@bio.kuleuven.be) (Glastad et al., 2011), including the prime model organisms Drosophila melanogaster and Caenorhabdi...

show abstract

Histone lysine demethylases as targets for anticancer therapy

Cited by 415 publications

References 178 publications

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease

Epigenetics and locust life phase transitions

Contact Info

Product

Resources

About