Histone modifications in embryo implantation and placentation: insights from mouse models

Bi, Sheng; Tu, Zhaowei; Chen, Dunjin; Zhang, Shuang

doi:10.3389/fendo.2023.1229862

Cited by 3 publications

(1 citation statement)

References 127 publications

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“…DNA methylation of several specific genes in early embryos may affect blastocyst formation and the gastrulation process by altering the transcriptional regulation of lineage-specific genes [64] . In a mouse model, histone modifications, such as methylation, acetylation, and ubiquitination, play crucial roles in regulating gene expression and chromatin remodeling during early embryonic development [65] . However, the current understanding of comparative histone modifications in split and intact human embryos is incomplete.…”

Section: Epigenetic Modificationsmentioning

confidence: 99%

Fate of human twin embryos generated unintentionally in in vitro fertilization: Clinical and ethical perspectives

Kinoshita,

Bhor

2024

Int. J. Clin. Obstet. Gynaecol.

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In vitro embryo splitting or twinning is a method of reproductive cloning that involves dividing a single early-stage embryo into two or more individual cells and growing them as identical embryos. The first successful intentional in vitro human embryo splitting, reported in 1993, sparked a heated ethical discussion on the cloning of human embryos. Later, the intricacies of the ethical debate related to cloning through human embryo splitting were globally recognized. In response to this, several countries and international organizations have implemented prohibitions either through legal statutes, official decrees, or public statements. However, most of the studies reported the post-implantation spontaneous embryo splitting in utero that results into monozygotic twins or multiples and aren't fall under the prohibitions of cloning. Recently, rare cases of unintentional in vitro embryo splitting were confirmed during their culture mostly due to naturally zona-free oocytes or zona manipulations. Due to the ambiguity of current legislation to discriminate between intentional or unintentional in vitro embryo splitting, the fate of those embryos to transfer or not, remains a question. After assessing the potential risk associated with, there is a need to reconsider the prohibitions imposed on transfer of unintentionally generated split embryos in poor responders and advanced maternal age patients undergoing IVF treatment, where the use of donor gametes is also prohibited. This review paper describes the various IVF laboratory procedures that rarely and unintentionally generates split embryos. Moreover, the cellular and molecular changes occurring in split embryos and ethical considerations about use of split embryos to transfer are also deliberated.

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Section: Epigenetic Modificationsmentioning

confidence: 99%

Fate of human twin embryos generated unintentionally in in vitro fertilization: Clinical and ethical perspectives

Kinoshita,

Bhor

2024

Int. J. Clin. Obstet. Gynaecol.

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Epigenetic alteration of uterine Leukemia Inhibitory Factor gene after glyphosate or a glyphosate-based herbicide exposure in rats

Almirón,

Lorenz,

Doná

et al. 2024

Environmental Toxicology and Pharmacology

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Hemoglobin mediates the link between 'weekend warrior' activity pattern and diabetic retinopathy

Li,

Ning,

Hou

et al. 2024

Preprint

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Diabetic retinopathy (DR), the leading cause of vision loss in the elderly, coupled with limited treatment options, has prompted efforts to identify modifiable risk factors associated with DR. The purpose of this study was to explore the association between WW physical activity patterns and DR risk in US adults and to examine how Hb levels mediate this relationship. Cross-sectional study data were obtained from nationally representative NHANES data from 2007-2018. PA patterns were categorized according to inactive, insufficiently active, WW, and regularly active (RA). Multivariate logistic regression models adjusting for demographics, behavioral factors, and health conditions were used to explore the association between PA patterns and DR. Finally, mediation analyses verified whether Hb mediated the relationship between PA and DR. The study ultimately included 5092 U.S. adults, including 857 participants with DR and 4235 participants with DM without DR. Multivariate logistic regression modelling indicated that both WW (OR=0.601, 95% CI=0.452-0.798, P<0.001) and RA (OR=0.728, 95% CI=0.554-0.956, P=0.023) were significant protective factors for DR when compared to inactive adults, and the association between RA insufficiently active, WW did not show a significant association with DR. Mediation analysis showed a significant mediation effect of Hb on the association between PA patterns and DR risk, with a mediation ratio of 5.23%. Our study reveals that WW and RA activity patterns are protective factors for DR and that Hb levels mediate this association. This suggests that WW activity patterns are more cost-effective for the prevention of DR.

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Histone modifications in embryo implantation and placentation: insights from mouse models

Cited by 3 publications

References 127 publications

Fate of human twin embryos generated unintentionally in in vitro fertilization: Clinical and ethical perspectives

Fate of human twin embryos generated unintentionally in in vitro fertilization: Clinical and ethical perspectives

Epigenetic alteration of uterine Leukemia Inhibitory Factor gene after glyphosate or a glyphosate-based herbicide exposure in rats

Hemoglobin mediates the link between 'weekend warrior' activity pattern and diabetic retinopathy

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