Histone post-translational modifications — cause and consequence of genome function

Millán-Zambrano, Gonzalo; Burton, Adam; Bannister, Andrew J.; Schneider, Robert

doi:10.1038/s41576-022-00468-7

Cited by 499 publications

(316 citation statements)

References 236 publications

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“…Notch 3 protein is a transmembrane receptor and was recently shown to be involved in late megakaryocyte differentiation ( 35 ). Transcriptomic changes might be linked to our here reported histone post-translational modifications, where histone acetylation and propionylation are marks of active chromatin ( 44 – 46 ). Further, flow cytometry analysis revealed that C3 also increased CD61 surface expression, a marker of megakaryocyte maturation.…”

Section: Discussionmentioning

confidence: 73%

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

et al. 2022

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Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow. Increased megakaryocyte expansion across common autoimmune diseases was shown for RA, systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). In this context, we evaluated the role of the microbial-derived short chain fatty acid (SCFA) propionate on hematopoietic progenitors in the collagen induced inflammatory arthritis model (CIA) as we recently showed attenuating effects of preventive propionate treatment on CIA severity. In vivo, propionate treatment starting 21 days post immunization (dpi) reduced the frequency of MEPs in the bone marrow of CIA and naïve mice. Megakaryocytes numbers were reduced but increased the expression of the maturation marker CD61. Consistent with this, functional analysis of platelets showed an upregulated reactivity state following propionate-treatment. This was confirmed by elevated histone 3 acetylation and propionylation as well as by RNAseq analysis in Meg-01 cells. Taken together, we identified a novel nutritional axis that skews platelet formation and function.

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Section: Discussionmentioning

confidence: 73%

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

et al. 2022

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“…Gene regulation can also be performed by influencing the affinity between other transcription factors and structural genes promoters. 19 Among them, histone methylation and acetylation are well studied (Fig. 2 ).…”

Section: Epigenetic Regulatory Mechanismsmentioning

confidence: 99%

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Shi

Zhang

Huang

et al. 2022

Sig Transduct Target Ther

157

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Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and association analyses and candidate gene approaches illustrate the multigenic complexity of cardiovascular disease. Several epigenetic mechanisms, such as DNA methylation, histone modification, and noncoding RNA, which are of importance for cardiovascular disease development and regression. Targeting epigenetic key enzymes, especially the DNA methyltransferases, histone methyltransferases, histone acetylases, histone deacetylases and their regulated target genes, could represent an attractive new route for the diagnosis and treatment of cardiovascular diseases. Herein, we summarize the knowledge on epigenetic history and essential regulatory mechanisms in cardiovascular diseases. Furthermore, we discuss the preclinical studies and drugs that are targeted these epigenetic key enzymes for cardiovascular diseases therapy. Finally, we conclude the clinical trials that are going to target some of these processes.

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“…Histone post-translational modifications (hPTMs) impact chromatin structure and accessibility, which ultimately influence transcription regulation. The histone code is finely regulated and particularly difficult to study as it can include more than 100 different hPTMs that are often gene- and cell-specific (Millán-Zambrano et al, 2022 ). However, some experience-dependent marks have been linked to CP regulation, such as phosphorylated H3 and H3/H4 acetylation (Putignano et al, 2007 ).…”

Section: Insight On Epigenetic Mechanisms Within Fs-pv Cellsmentioning

confidence: 99%

Non-Cell-Autonomous Factors Implicated in Parvalbumin Interneuron Maturation and Critical Periods

Gibel-Russo

Benacom

Nardo

2022

Front. Neural Circuits

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From birth to adolescence, the brain adapts to its environmental stimuli through structural and functional remodeling of neural circuits during critical periods of heightened plasticity. They occur across modalities for proper sensory, motor, linguistic, and cognitive development. If they are disrupted by early-life adverse experiences or genetic deficiencies, lasting consequences include behavioral changes, physiological and cognitive deficits, or psychiatric illness. Critical period timing is orchestrated not only by appropriate neural activity but also by a multitude of signals that participate in the maturation of fast-spiking parvalbumin interneurons and the consolidation of neural circuits. In this review, we describe the various signaling factors that initiate critical period onset, such as BDNF, SPARCL1, or OTX2, which originate either from local neurons or glial cells or from extracortical sources such as the choroid plexus. Critical period closure is established by signals that modulate extracellular matrix and myelination, while timing and plasticity can also be influenced by circadian rhythms and by hormones and corticosteroids that affect brain oxidative stress levels or immune response. Molecular outcomes include lasting epigenetic changes which themselves can be considered signals that shape downstream cross-modal critical periods. Comprehensive knowledge of how these signals and signaling factors interplay to influence neural mechanisms will help provide an inclusive perspective on the effects of early adversity and developmental defects that permanently change perception and behavior.

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Histone post-translational modifications — cause and consequence of genome function

Cited by 499 publications

References 236 publications

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Non-Cell-Autonomous Factors Implicated in Parvalbumin Interneuron Maturation and Critical Periods

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