Histone profiles in cancer

Riedel, Simone S.; Neff, Tobias; Bernt, Kathrin M.

doi:10.1016/j.pharmthera.2015.07.004

Cited by 7 publications

(1 citation statement)

References 347 publications

(381 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other histone modifications, including acetylation and H3K4, H3K36, and H3K79 methylation, are associated with the transcriptionally active state, and some of the enzymes responsible for these modifications have been implicated in driving tumorigenesis (Bernt et al 2011;Colon-Bolea and Crespo 2014;Riedel et al 2015). From the perspective of cancer therapeutics, these activation-associated modifications represent attractive targets, insofar as inhibition of the enzymes that are involved in the gene activation process might be expected to down-regulate oncogenes that are aberrantly expressed in cancer.…”

Section: Modifying Nucleosomesmentioning

confidence: 99%

Mechanisms of Nucleosome Dynamics In Vivo

Henikoff

2016

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

Nucleosomes function to tightly package DNA into chromosomes, but the nucleosomal landscape becomes disrupted during active processes such as replication, transcription, and repair. The realization that many proteins responsible for chromatin regulation are frequently mutated in cancer has drawn attention to chromatin dynamics; however, the basic mechanisms whereby nucleosomes are disrupted and reassembled is incompletely understood. Here, I present an overview of chromatin dynamics as has been elucidated in model organisms, in which our understanding is most advanced. A basic understanding of chromatin dynamics during normal developmental processes can provide the context for understanding how this machinery can go awry during oncogenesis.

show abstract

Section: Modifying Nucleosomesmentioning

confidence: 99%

Mechanisms of Nucleosome Dynamics In Vivo

Henikoff

2016

Cold Spring Harb Perspect Med

View full text Add to dashboard Cite

show abstract

Aberrant DNA Methylation and Histone Modifications in Cancer

Hudler

2016

Encyclopedia of Life Sciences

View full text Add to dashboard Cite

DNA (deoxyribonucleic acid) methylation of cytosines in CpG dinucleotides and post‐translational modifications of histone amino acids are epigenetic mechanisms that are in normal cells involved in specific cell functions, particularly in regulation of transcription and maintenance of stable chromatin. The epigenetic code is highly dynamic and enables the cells to regulate their responses to the intrinsic or environmental signals. Aberrations of DNA methylation patterns and histone modifications are major features observed in all types of cancer. Integrated research of genomic alterations, erroneous gene expression and modifications of epigenomes in cancer cells has revealed the complexity and heterogeneity of this disease. Some of the novel therapeutic and diagnostic approaches based on aberrant promoter hypermethylation and histone modifications, particularly acetylation, have already been translated into a clinical setting, whereas a number of others are being examined in clinical trials. Key Concepts DNA methylation and histone modifications cooperate in regulation of certain cell functions and responses. Cancer development and progression are characterised by diverse aberrations in epigenetic profiles. Changes in DNA methylation profiles could be used to define specific subsets of cancers, which harbour characteristic genetic alterations. Hypermethylation or hypomethylation of gene promoters, resulting in silencing or activating the gene transcription, respectively, are fundamental in the identification of novel tumour suppressors and oncogenes. Unravelling the functional consequences of methylation signature in nonpromoter regions is complex and will require further research efforts to discern their role in healthy and diseased cells. Epigenetic profiling of cancers has already identified and is still identifying novel targets for the development of therapeutic and diagnostic approaches.

show abstract

Epigenetics in the Diagnosis, Prognosis, and Therapy of Cancer

Fu,

Liu

2023

Epigenetics and Human Health

View full text Add to dashboard Cite

Histone profiles in cancer

Cited by 7 publications

References 347 publications

Mechanisms of Nucleosome Dynamics In Vivo

Mechanisms of Nucleosome Dynamics In Vivo

Aberrant DNA Methylation and Histone Modifications in Cancer

Epigenetics in the Diagnosis, Prognosis, and Therapy of Cancer

Contact Info

Product

Resources

About