Histones and chymotrypsin-like elastases play significant roles in the antimicrobial activity of tongue sole neutrophil extracellular traps

Wen, Li-Lian; Zhao, Mingli; Chi, Heng; Sun, Li

doi:10.1016/j.fsi.2017.11.004

Cited by 14 publications

(12 citation statements)

References 47 publications

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“…dogs, rodents, horses) (Etulain et al , ; Li, Ng & Tablin, ; Vargas et al , ) and non‐mammal vertebrate species (e.g. crocodile, fish, chicken) (Palić et al , ; Kozlowski et al , ; Pieper et al , ; Wen et al , ), as well as for invertebrates such as the social amoeba Dictyostelium discoideum (Zhang et al , ) and the earthworm Eisenia andrei (Homa et al , ). Since most research on the topic of ETs has focused on neutrophils, we similarly focus on neutrophils and NET formation in this review.…”

Section: Introductionmentioning

confidence: 99%

Root extracellular traps versus neutrophil extracellular traps in host defence, a case of functional convergence?

et al. 2019

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The root cap releases cells that produce massive amounts of mucilage containing polysaccharides, proteoglycans, extracellular DNA (exDNA) and a variety of antimicrobial compounds. The released cells – known as border cells or border‐like cells – and mucilage secretions form networks that are defined as root extracellular traps (RETs). RETs are important players in root immunity. In animals, phagocytes are some of the most abundant white blood cells in circulation and are very important for immunity. These cells combat pathogens through multiple defence mechanisms, including the release of exDNA‐containing extracellular traps (ETs). Traps of neutrophil origin are abbreviated herein as NETs. Similar to phagocytes, plant root cap‐originating cells actively contribute to frontline defence against pathogens. RETs and NETs are thus components of the plant and animal immune systems, respectively, that exhibit similar compositional and functional properties. Herein, we describe and discuss the formation, molecular composition and functional similarities of these similar but different extracellular traps.

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Section: Introductionmentioning

confidence: 99%

Root extracellular traps versus neutrophil extracellular traps in host defence, a case of functional convergence?

et al. 2019

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“…The NETs analysed, in this study, were released from viable neutrophils, suggesting a non-cell death pathway of NETosis in teleost [89]. Further studies by the same group found histones and chymotrypsin-like elastases to be involved in the antimicrobial activity of those teleost ETs [155]. Gratacap and colleagues used a transparent zebrafish swim bladder infection model to analyse NET formation [90].…”

Section: Extracellular Traps In Teleostsmentioning

confidence: 56%

Extracellular Traps: An Ancient Weapon of Multiple Kingdoms

Neumann

Brogden²,

Köckritz-Blickwede

2020

Biology

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The discovery, in 2004, of extracellular traps released by neutrophils has extended our understanding of the mode of action of various innate immune cells. This fascinating discovery demonstrated the extracellular trapping and killing of various pathogens by neutrophils. During the last decade, evidence has accumulated showing that extracellular traps play a crucial role in the defence mechanisms of various cell types present in vertebrates, invertebrates, and plants. The aim of this review is to summarise the relevant literature on the evolutionary history of extracellular traps used as a weapon in various kingdoms of life. Biology 2020, 9, 34 2 of 23On the basis of findings from several studies mostly performed with human and murine neutrophils, the following three different pathways that lead to the formation of ETs by innate immune cells have been identified: (1) Release of nuclear DNA by ETosis, a suicidal cell death associated with the rupture of the nuclear membrane prior to cell lysis [14,15]; (2) vesicular release of nuclear DNA by viable cells [16,17]; and (3) release of mitochondrial DNA [18,19]. However, the exact molecular mechanisms leading to one or the other phenotype of ET formation has still not been entirely clarified. A group of renowned scientists and experts on NETs has recently published an opinionated review on the subject due to the abundance of available data that has also led to some confusion in the NET/ET research community because of contradictory results and divergent scientific concepts, for example, the molecular pathways of ET formation or the origin of the DNA that forms the ET scaffold [20]. There is a strong consensus about the composition of ETs among the findings that NETs contain a high amount of granule proteins, for example, cell-type-specific proteases and other antibacterial molecules that are associated with DNA-histone complexes. However, it is still unclear how different triggers or pathways have led to phenotypical differences about the source of DNA or viability of the ET-releasing cell.Comparison of ET phenotypical differences between host species in relation to evolutionary aspects, especially by comparing data from phylogenetic groups, would help to understand the pathways of ET formation in more detail.

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“…However, although the mechanisms in which histones intervene in NETs in fish are still unknown, it is demonstrated that they play a fundamental role in the formation of these traps, since their blockage with specific antibodies inhibits their antimicrobial function (Wen et al . ).…”

Section: Antimicrobial Activities Of Fish Antimicrobial Peptidesmentioning

confidence: 97%

“…In vertebrates, it has been demonstrated that several histones or fractions cleaved from them develop a wide range of antimicrobial functions by penetrating into the bacteria through the membranes, binding then to its genetic material or entrapping the pathogens, forming neutrophil extracellular traps (NETs) (Kawasaki & Iwamuro 2008). However, although the mechanisms in which histones intervene in NETs in fish are still unknown, it is demonstrated that they play a fundamental role in the formation of these traps, since their blockage with specific antibodies inhibits their antimicrobial function (Wen et al 2018).…”

Section: Antimicrobial Activities Of Fish Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial peptides from fish: beyond the fight against pathogens

Valero

Saraiva‐Fraga

Costas

et al. 2018

Reviews in Aquaculture

100

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Fish antimicrobial peptides (AMPs) are small peptides whose actions have great implications in the innate immune response of teleost fish, being considered critical as the first line of defence against a wide spectrum of pathogens. Antibiotics have been widely used in aquaculture, resulting in bacterial resistance. The potential of AMPs as alternative to antibiotics makes them a very interesting tool as they represent lower‐risk peptides to develop resistances, or even in the fight against other pathogens such as viruses. Beyond their antimicrobial function, fish AMPs possess several relevant but little‐known characteristics and capabilities such as host‐defence peptides, antioxidants, active compounds of immunogenic drugs and as adjuvants. Moreover, their antitumour properties make them potential drugs to be used in oncological treatments in human subjects. Novel methodologies as clustered regularly interspaced short palindromic repeats associated proteins system (CRISPR‐Cas), or even their use as nutraceutics, seem to be promising instruments to enlarge the functions of fish AMPs. This review discusses these new methodologies, as well as the latest research on fish AMP functions, newly discovered properties of AMPs and their future applications in both the aquaculture industry and human health care.

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Histones and chymotrypsin-like elastases play significant roles in the antimicrobial activity of tongue sole neutrophil extracellular traps

Cited by 14 publications

References 47 publications

Root extracellular traps versus neutrophil extracellular traps in host defence, a case of functional convergence?

Root extracellular traps versus neutrophil extracellular traps in host defence, a case of functional convergence?

Extracellular Traps: An Ancient Weapon of Multiple Kingdoms

Antimicrobial peptides from fish: beyond the fight against pathogens

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