Histones on fire: the effect of Dun1 and Mrc1 on origin firing and replication of hyper-acetylated genomes

Gershon, Lihi; Kupiec, Martin

doi:10.1007/s00294-021-01175-2

Cited by 1 publication

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References 46 publications

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“…Nevertheless, hyper-acetylation of H3K56 in yeast has been shown to induce replicative stress. In this case, the replisome must process a histone configuration that is usually found behind the replication fork, rather than in front of it, which may induce the stalling or even the collapse of the fork [ 104 ]. In addition, pericentromeric heterochromatin in mouse ES cells switches from early-mid to late S-phase replication upon differentiation due to an increase in chromatin condensation and a decrease in its acetylation [ 105 ].…”

Section: Other Sources Of Replication Stress During Replication and Their Potential Relation-ship With Replication Timingmentioning

confidence: 99%

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship

Briu

Maric

Cadoret

2021

IJMS

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The replication-timing program constitutes a key element of the organization and coordination of numerous nuclear processes in eukaryotes. This program is established at a crucial moment in the cell cycle and occurs simultaneously with the organization of the genome, thus indicating the vital significance of this process. With recent technological achievements of high-throughput approaches, a very strong link has been confirmed between replication timing, transcriptional activity, the epigenetic and mutational landscape, and the 3D organization of the genome. There is also a clear relationship between replication stress, replication timing, and genomic instability, but the extent to which they are mutually linked to each other is unclear. Recent evidence has shown that replication timing is affected in cancer cells, although the cause and consequence of this effect remain unknown. However, in-depth studies remain to be performed to characterize the molecular mechanisms of replication-timing regulation and clearly identify different cis- and trans-acting factors. The results of these studies will potentially facilitate the discovery of new therapeutic pathways, particularly for personalized medicine, or new biomarkers. This review focuses on the complex relationship between replication timing, replication stress, and genomic instability.

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Section: Other Sources Of Replication Stress During Replication and Their Potential Relation-ship With Replication Timingmentioning

confidence: 99%

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship

Briu

Maric

Cadoret

2021

IJMS

View full text Add to dashboard Cite

show abstract

Histones on fire: the effect of Dun1 and Mrc1 on origin firing and replication of hyper-acetylated genomes

Cited by 1 publication

References 46 publications

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship

Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship

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