Histopathologic Alterations in the Decidua in Human Spontaneous Abortion: Loss of Cells With Large Cytoplasmic Granules

Abstract

The histopathology of decidua obtained from the placental bed was evaluated by phloxine-tartrazine staining, which allows clear definition of cells with cytoplasmic granules. Mononuclear cells with large granules were seen in biopsy specimens taken from women at 8-31 weeks of normal pregnancy. In contrast, cells with large granules were missing in sections taken from the decidua of five women who were aborting or were destined to abort. Since the presence of suppressor cell activity in murine decidua correlates with the success of pregnancy and since this suppression is associated with small lymphocytes with cytoplasmic granules, the observations made using human placental bed biopsy material suggest that a possible suppressor cell deficiency might occur in the early stages of spontaneous abortion in human females.

The Nutritional Classification of Pregnant Women Using Support Vector Machine (SVM)

“…Jika kebutuhan energi, protein, lemak, vitamin, dan mineral yang meningkat ini tidak dapat dipenuhi melalui makanan yang dikonsumsi oleh ibu hamil maka akan mengalami kekurangan gizi. Kekurangan gizi selama kehamilan dapat meningkatkan risiko kematian ibu, selain itu kekurangan gizi juga dapat meningkatkan risiko kelahiran prematur, yang dapat menyebabkan berbagai masalah kesehatan pada bayi, termasuk sindrom gangguan pernapasan, infeksi, dan keterlambatan perkembangan, berat badan lahir rendah, yang dikaitkan dengan peningkatan risiko kematian bayi dan masalah kesehatan jangka panjang seperti keterlambatan perkembangan dan penyakit kronis (Clark DA et al, 1987) (Rahadini, A.A., & Rahmat, R.R., 2018) (Sastri, N., 2022). Semakin muda usia ibu hamil, semakin banyak nutrisi yang dibutuhkannya.…”