Histopathologic basis of clinical findings in poliomyelitis

Bodian, David

doi:10.1016/0002-9343(49)90130-8

Cited by 186 publications

(85 citation statements)

References 9 publications

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“…4 E and F) and prominent signs of inflammation (Fig. 4 C and E-G), previously described with PV-caused poliomyelitis in patients (22). We detected mononuclear cell infiltrates of predominantly microglial͞macrophage origin diffusely distributed in the anterior horn gray matter (Fig.…”

Section: Resultssupporting

confidence: 73%

A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice

Dufresne

Gromeier

2004

Proc. Natl. Acad. Sci. U.S.A.

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Coxsackievirus A21 (CAV21) is classified within the species Human enterovirus C (HEV-C) of the Enterovirus genus of picornaviruses. HEV-C share striking homology with the polioviruses (PV), their closest kin among the enteroviruses. Despite a high level of sequence identity, CAV21 and PV cause distinct clinical disease typically attributed to their differential use of host receptors. PV cause poliomyelitis, whereas CAV21 shares a receptor and a propensity to cause upper respiratory tract infections with the major group rhinoviruses. As a model for CAV21 infection, we have developed transgenic mice that express human intercellular adhesion molecule 1, the cell-surface receptor for CAV21. Surprisingly, CAV21 administered to these mice via the intramuscular route causes a paralytic condition consistent with poliomyelitis. The virus appears to invade the CNS by retrograde axonal transport, as has been demonstrated to occur in analogous PV infections. We detected human intercellular adhesion molecule 1 expression on both transgenic mouse and human spinal cord anterior horn motor neurons, indicating that members of HEV-C may share PV's potential to elicit poliomyelitis in humans.

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Section: Resultssupporting

confidence: 73%

A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice

Dufresne

Gromeier

2004

Proc. Natl. Acad. Sci. U.S.A.

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“…Namely, it was expected that Mustafa's wrist-walking may be due to a vermal atrophy as the result of the suspected poliomyelitis because there were vermal atrophies in the wrist-walkers of the first and second families discovered (see Tan, 2005;Tan, 2006a,b,c). It is known that the spinal motor neurons may be partially destroyed by the poliomyelitis virus; other sites within the brain such as s medulla, cerebellar vermis, midbrain, thalamus, and cerebral cortex may also be affected as well (Bodian, 1949;Baker & Cornwell, 1954;Curnen & Chamberlin, 1962). The MRI scans showed, however, that all of the cerebral structures seemed to be normal.…”

Section: Discussionmentioning

confidence: 99%

A Wrist-Walker Exhibiting No “Uner Tan Sydnrome”: A Theory for Possible Mechanisms of Human Devolution Toward the Atavistic Walking Patterns

Tan

2007

International Journal of Neuroscience

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“…16 In contrast, in autopsy studies of polio patients, many other regions in the brainstem and basal ganglia were also affected. 2,3 Also, histologic, imaging and neuroendocrine studies in polio patients showed that the motor cortex, basal ganglia, and reticular activation system bore the brunt of injury. 6 Based on these observations, it is likely that the neurochemical mechanisms responsible for causing fatigue in postpolio patients are different from those pathways modulated by modafinil.…”

Section: Discussionmentioning

confidence: 99%

Randomized controlled trial of modafinil for the treatment of fatigue in postpolio patients

et al. 2005

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The purpose of this study was to test whether modafinil is effective in alleviating the symptoms of fatigue in postpolio patients, because it has been helpful for such symptoms in other neurologic disorders. Using a double-blind, randomized, placebo-controlled cross-over design, 14 postpolio patients with moderate to severe fatigue were assigned to receive modafinil or placebo first. Piper Fatigue Scale, Epworth Sleepiness Scale, digit span, and reaction time tests were done at baseline and then at weekly intervals. The Piper Fatigue Scale scores improved by 27 Ϯ 40% (mean Ϯ SD) following modafinil and by 43 Ϯ 36% following placebo. Scores for most of the other tests did not change during the study. Therefore, we conclude that modafinil was not effective in alleviating the symptoms of fatigue in postpolio patients.

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Histopathologic basis of clinical findings in poliomyelitis

Cited by 186 publications

References 9 publications

A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice

A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice

A Wrist-Walker Exhibiting No “Uner Tan Sydnrome”: A Theory for Possible Mechanisms of Human Devolution Toward the Atavistic Walking Patterns

Randomized controlled trial of modafinil for the treatment of fatigue in postpolio patients

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