Histopathologic diagnosis of ultra‐early autoimmune gastritis: A case report

Terao, Shuichi; Suzuki, Shigeaki; Kushima, Ryoji

doi:10.1002/ccr3.7458

Cited by 2 publications

(2 citation statements)

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“…There was a lack of significant lymphocytic infiltration in Case 2, which diverged from previous reports on early-stage AIG. Terao et al (27) suggested that the identification of early-stage AIG should focus on the slight degeneration of the parietal cells and pseudopyloric gland metaplasia of the chief cells. Our histopathology revealed pseudohypertrophy of the parietal cells and pseudo-pyloric gland metaplasia, supporting the findings of Terao et al Therefore, whether both lymphocytic infiltration and parietal cell degeneration are necessary, and the sequence of their appearance needs to be further clarified.…”

Section: Discussionmentioning

confidence: 99%

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Unveiling early stage autoimmune gastritis: novel endoscopic insights from two case reports

Yu,

Shangguan,

et al. 2024

Front. Immunol.

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The predominant characteristic of autoimmune gastritis (AIG) is corpus-dominant advanced atrophy, which is mostly observed in the middle to late stages. More reports are needed on the endoscopic features of the early stage. In this report, we present two cases of early-stage AIG in which endoscopic examinations showed no atrophy of the gastric mucosa but displayed a transition of collecting venules from a regular to an irregular arrangement. In addition, yellowish-white cobblestone-like elevations were observed in the fundic gland region. Histologically, the observed manifestations included pseudohypertrophy and protrusion of parietal cells into the lumen, possibly along with hyperplasia of G cells, lymphocytic infiltration and potentially pseudopyloric gland metaplasia. Serologically, the anti-parietal cell antibody returned positive results, whereas the anti-intrinsic factor antibody yielded negative results. In this study, we summarized some endoscopic features of two patients, aiming to provide clues for endoscopists to detect early-stage AIG.

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Section: Discussionmentioning

confidence: 99%

“…Terao et al. ( 27 ) suggested that the identification of early-stage AIG should focus on the slight degeneration of the parietal cells and pseudopyloric gland metaplasia of the chief cells. Our histopathology revealed pseudohypertrophy of the parietal cells and pseudo-pyloric gland metaplasia, supporting the findings of Terao et al.…”

Section: Discussionmentioning

confidence: 99%