Histopathologic Evaluation of Liver Biopsy for Cirrhosis

Ma, Changqing; Brunt, Elizabeth M.

doi:10.1097/pap.0b013e31825c6bab

Cited by 14 publications

(11 citation statements)

References 70 publications

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“…Cirrhosis is the end result of liver injury characterized by distortion of the hepatic architecture by extensive fibrosis and formation of regenerative nodules [5]. Cirrhosis is defined by its typical pathological features: 1) presence of regenerating nodules of hepatocytes and 2) presence of bridging fibrosis between these nodules [5].…”

Section: Discussionmentioning

confidence: 99%

“…Cirrhosis is defined by its typical pathological features: 1) presence of regenerating nodules of hepatocytes and 2) presence of bridging fibrosis between these nodules [5]. CT findings of cirrhosis usually include diffuse hepatic surface nodularity and/or signs of portal hypertension such as splenomegaly, ascites, or portosystemic varices [6].…”

Section: Discussionmentioning

confidence: 99%

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Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy

Lee

Chang

et al. 2014

Cancer Res Treat

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Pseudocirrhosis refers to a condition that shows changes in hepatic contour that mimic cirrhosis radiographically in the absence of the typical histopathological findings of cirrhosis. This condition has been observed in patients with cancer metastatic to the liver, both in those who have undergone prior systemic chemotherapy and those who have not. Pseudocirrhosis may cause difficulty in interpretation of the response to chemotherapy and hepatic decompression and complication of portal hypertension have a negative effect on the prognosis. We report on a case of breast cancer with liver metastases that showed cirrhotic changes during disease progression. Progression of liver metastases was confirmed by F18 fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT). We also performed ultrasound-guided liver biopsy and confirmed tumor infiltration with severe desmoplastic fibrosis. This case suggests the pathogenesis of pseudocirrhosis through histopathological findings and the role of PET-CT in evaluation of the response to chemotherapy in patients with pseudocirrhosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy

Lee

Chang

et al. 2014

Cancer Res Treat

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“…Cirrhosis is considered to be the final stage of any chronic liver disease, characterized by the replacement of the normal hepatic tissue by extensive fibrosis, regenerative nodules formation, and bridging fibrosis leading to distortion of the normal hepatic architecture. [9] The radiological findings of cirrhosis include diffuse nodularity, and a lobulated and relatively small liver. Moreover, signs of portal hypertension, such as splenomegaly, ascites and portosystemic shunts [7] may be seen.…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy induced pseudo-cirrhosis in a breast cancer patient with liver metastasis: A case report and review of the literature

Lahav

Mowaswes

Fteiha

et al. 2016

CRIM

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We report a case of 55-year-old female patient with past medical history of left breast invasive ductal carcinoma in situ who was admitted to the hospital due to ascites and peripheral edema. Following an extensive investigations, the patient was diagnosed with chemotherapy induced pseudo-cirrhosis which developed after chemotherapeutic treatment with cyclophosphamide/adriamycin followed by cisplatin and gemfibrozil for recurrent breast cancer with, lungs, liver and bone metastasis which progressed to clinical cirrhosis. The patient was managed with aggressive diuresis and albumin infusions, however without resolution of both the clinical symptoms of cirrhosis and the pseudo-cirrhotic appearance of the liver. This case demonstrates that the development of chemotherapy induced pseudo-cirrhosis can rapidly progress to true clinical cirrhosis with its life-threatening complications. Thus, clinicians and radiologist should be well aware of this entity as early recognition and management can lead to a near complete recovery of liver function and much improved quality of life.

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“…Cirrhosis is the 14th dead cause worldwide in adults [1]; this pathology represents an hepatocellular alteration, which is defined histologically by a vascular remodeling that triggers formation of fibrotic interconnected septum that wraps the entire liver tissue and divides the parenchyma in nodules [2]; as a consequence, there is a reduction in hepatocellular mass as well as liver function and blood flow alterations. These pathologic characteristics are independent of disease etiology, which mainly could be alcoholic, biliary, and directed by viral or chronic hepatitis [3].…”

Section: Introductionmentioning

confidence: 99%

“…This is evident in successfully chronic hepatitis C treatment, in fibrosis resolution in hemochromatosis patients with effective treatment, and also in alcoholic liver illness patient who has suspended alcohol consumption [10]. A group of histopathological injuries of "reverted cirrhosis" has been described in the "hepatic reparatory complex" [9] including a thin, incomplete and perforated septum, through which hepatocytes are evident; there is a hepatocyte growing in terminal hepatic venules and little cumulus of thick collagen fibers in the parenchymal sinusoids [2]. Nevertheless, this disease could be considered as a pre-neoplastic state considering that 80% of hepatocellular carcinoma originated from cirrhosis [11].…”

Section: Introductionmentioning

confidence: 99%

Molecular and Cellular Aspects of Cirrhosis and How an Adenosine Derivative Could Revert Fibrosis

Rodríguez‐Aguilera¹,

Vaca²,

Guerrero‐Celis³

et al. 2019

Liver Cirrhosis - Debates and Current Challenges

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Hepatic fibrosis occurs in response to persistent liver damage and is characterized by an excessive accumulation of extracellular matrix. When the damage is prolonged, there is a chronic inflammation and persistent hepatic fibrosis eventually leads to cirrhosis, where in addition to the scar, there is an important vascular remodeling associated with portal hypertension and, if decompensated, leads to death or can develop hepatocellular carcinoma. We have been studying the pharmacologic functions of adenosine, finding that a derivative of this nucleoside, IFC-305, shows hepatoprotective effects in a CCl 4-induced rat cirrhosis model where it reverses liver fibrosis through modulation of fibrosis-related genes and by ameliorating hepatic function. Furthermore, this compound has the property to rescue cell cycle inhibition in vivo, prevents hepatic stellate cell activation, modulates antiinflammatory macrophage polarization, and favors a chromatin context that could decrease the genomic instability and characteristics of cirrhosis, enabling the recovery of gene expression profile. Here we show results that contribute to the comprehension of molecular and cellular mechanism of cirrhosis, give the opportunity to suggest biomarkers to the early diagnostic of this pathology, and constitute the fundaments to suggest IFC-305 as a coadjuvant for treatment of this disease.

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Histopathologic Evaluation of Liver Biopsy for Cirrhosis

Cited by 14 publications

References 70 publications

Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy

Pseudocirrhosis of Breast Cancer Metastases to the Liver Treated by Chemotherapy

Chemotherapy induced pseudo-cirrhosis in a breast cancer patient with liver metastasis: A case report and review of the literature

Molecular and Cellular Aspects of Cirrhosis and How an Adenosine Derivative Could Revert Fibrosis

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