Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats

Hasheminia, Seyed Mohsen; Razavi, SeyedMohammad; Feizi, Mostafa

doi:10.2334/josnusd.53.15

Cited by 12 publications

(14 citation statements)

References 28 publications

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“…The results showed minor inflammatory infiltration after 7 days, which then returned to normal after 30 days. The same observation was recorded by others (Farhad et al 2011, Parirokh et al 2011, and they reported a less severe or no inflammatory reaction of subcutaneous tissue to an implanted empty tube after 30 days. Olsson et al (1981) concluded that all dental materials have distinct irritability.…”

Section: Discussionsupporting

confidence: 83%

Biocompatibility of BioAggregate and mineral trioxide aggregate on the liver and kidney

Khalil

Eid

2013

Int Endodontic J

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Section: Discussionsupporting

confidence: 83%

Biocompatibility of BioAggregate and mineral trioxide aggregate on the liver and kidney

Khalil

Eid

2013

Int Endodontic J

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“…60 or 90 days 9 . As regards the groups evaluated, zinc oxide presented the highest degrees of inflammatory infiltration, as has previously been observed, due its cytotoxicity 25 . Although this substance presented good results with respect to tissue repair, probably due to its anti-oxidant power, anti-inflammatory potential and tissue repair activity 26,27 .…”

Section: Discussionsupporting

confidence: 65%

The biocompatibility of a new endodontic paste used in dental trauma

Soares

Prado

Brazão

et al. 2015

Rev. odontol. UNESP

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<title>Abstract</title><sec><title>Objective</title>This study investigated the short-term subcutaneous tissue reaction of a new endodontic paste, based on the association among calcium hydroxide [Ca(OH)2], 2% chlorhexidine gel (CHX) and zinc oxide (ZnO) in comparison with a control paste, and the individual substances alone.</sec><sec><title>Material and method</title>Twenty-four male wistar rats were used. Polyethylene tubes containing the materials were implanted into the dorsal connective tissue of rats. Empty implanted tubes served as controls. The materials used were: Ca(OH)2+CHX+ZnO paste in two different proportions (2:1:2) and (2:1:3), a control paste, Ca(OH)2+CHX (2:1), and the substances alone. After time intervals of 2, 3, 7 and 15 days, the animals were euthanized and the specimens prepared for histological processing. Data were evaluated qualitatively according to the levels of tissue repair and the degree of inflammation.</sec><sec><title>Result</title>On the second day all the materials were observed to cause a severe inflammatory response. On the third day, the pastes Ca(OH)2+CHX+ZnO (2:1:2) and (2:1:3) showed reduction in degree of inflammation. On seventh day the tissue was already more organized with presence of collagen fibers in all materials. After 15 days it was found that compound Ca(OH)2+CHX+ZnO (2:1:2) showed areas with no inflammatory infiltrate.</sec><sec><title>Conclusion</title>The experimental pastes, Ca(OH)2+CHX+ZnO in two different proportions (2:1:2) and (2:1:3), showed favorable results with respect to biocompatibility, when evaluated for a short-term.</sec>

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“…Because of the physical limitations of core materials, sealers play an important role in root canal obturation, as they fill all voids and spaces within the tooth [2].…”

Section: Introductionmentioning

confidence: 99%

Determination of trace elements in kidneys, livers and brains of rats with sealer implants by ICP-MS

Şımşek

Akinci

Alan

et al. 2017

Biotechnology & Biotechnological Equipment

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Following root canal treatment, sealers may contact periapical tissue. The purpose of this study was to evaluate the systemic toxic effects of epoxy resin-based sealers (AH Plus and Obtuseal). Inductively coupled plasma-mass spectrometry (ICP-MS) was used to measure levels of trace elements (beryllium, magnesium, aluminium, calcium, chromium, arsenic and lead) in the brain, kidney and liver of rats. Twenty sterilized polyethylene tubes were then filled with AH Plus and Obtuseal and implanted into the dorsal subcutaneous tissue of 10 rats; three unoperated animals were used as a control group. After 45 days, the rats were sacrificed by cervical dislocation following anaesthesia, and brains, kidneys and livers were removed from all experimental animals. ICP-MS analysis was used to determine levels of trace elements. Data were analysed using KruskalWallis and Connover post hoc tests. No significant differences were found in aluminium and calcium levels, but brains, kidneys and livers showed significantly higher amounts of magnesium and chromium than the corresponding controls. In the kidney and liver samples, arsenic levels were found to be higher than in the control group. Lead was detected at higher levels only in liver samples from the AH Plus group. Beryllium was not detected in any organ. It was concluded that AH Plus and Obtuseal release minimal quantities of trace elements when in contact with subcutaneous tissue, and further studies are needed to understand the systemic effects of these materials.

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Histopathologic evaluation of subcutaneous tissue response to three endodontic sealers in rats

Cited by 12 publications

References 28 publications

Biocompatibility of BioAggregate and mineral trioxide aggregate on the liver and kidney

Biocompatibility of BioAggregate and mineral trioxide aggregate on the liver and kidney

The biocompatibility of a new endodontic paste used in dental trauma

Determination of trace elements in kidneys, livers and brains of rats with sealer implants by ICP-MS

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