2016
DOI: 10.5858/arpa.2015-0389-oa
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Histopathologic Features of Prognostic Significance in High-Grade Osteosarcoma

Abstract: Context.-In osteosarcoma treated with neoadjuvant chemotherapy the extent of tumor necrosis on resection is considered an indicator of treatment response, and this has been shown to correlate with survival in most but not all studies.Objective.-To identify additional histologic variables of prognostic significance in high-grade osteosarcoma.Design.-Slides of pretreatment biopsy and primary postneoadjuvant chemotherapy resections from 165 patients with high-grade osteosarcoma were reviewed. Univariate (Kaplan-M… Show more

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Cited by 47 publications
(48 citation statements)
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“…Given that high mitotic counts are associated to OSA aggressiveness and poor prognosis [39] (Fig. 5a and b).…”
Section: Resultsmentioning
confidence: 96%
See 1 more Smart Citation
“…Given that high mitotic counts are associated to OSA aggressiveness and poor prognosis [39] (Fig. 5a and b).…”
Section: Resultsmentioning
confidence: 96%
“…After histological assessment of OSA tumors, we observed a signi cant increase in combined treatment-associated necrosis as well as a profound reduction in mitotic indices. These ndings bear high translational relevance given that necrosis rate in response to therapy and mitotic index determination are two histopathological parameters routinely used in the clinical management of OSA, linked to disease aggressiveness and prognosis [33,39]. Besides complementing chemotherapy, β-blockade using PPN could also show bene t during resection of primary or secondary OSA tumors in order to antagonize several deleterious mechanisms triggered by surgery, including in ammation and release of catecholamines, activation of proangiogenic and protumoral signaling pathways, tumor cell shedding, among others [46].…”
Section: Discussionmentioning
confidence: 99%
“…Tumors considered especially ''implantable'' such as chondrosarcoma [5,7] might provide an indication for biopsy tract removal. In addition, sarcomas treated with preoperative chemotherapy or radiation are less likely to have viable tumor cells in the tumor itself or biopsy tract [4,8]. Therefore, those patients who are not treated with preoperative radiation or chemotherapy might be better candidates for biopsy tract resection.…”
Section: Where Do We Need To Go?mentioning
confidence: 99%
“…Clinicopathologic features, inflammatory indices, nutritional indices, immune indices, and metabolic indices were the most commonly used and conventionally established prognostic indicators. [5][6][7][8][9][10] In contrast, some differentially expressed and tissue-specific proteins, micro-RNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) can also serve as reliable prognosticators in various neoplasms. [11][12][13][14] It is undoubtedly that all these predictors inherently and ineluctably harbor their merits and drawbacks.…”
Section: Introductionmentioning
confidence: 99%