Histopathologic prognostic factors in adenocarcinomas of the peripheral lung less than 2 CM in diameter

Abstract

The histologic prognostic factors of pulmonary adenocarcinomas of the lung less than 2 cm in diameter were analyzed in 75 patients who had undergone surgical resection. The pathologic stage, lymph node involvement, and pleural involvement were found to be the major determinants of prognosis (P less than 0.01). In addition, other single factors, such as tumor differentiation (P less than 0.01), vascular invasion (P less than 0.01), the degree of collagenization in the fibrotic focus (P less than 0.01), the standard deviation (SD) of nuclear areas (P less than 0.05), and mitotic index (P less than 0.05) correlated significantly with prognosis by the log-rank test on the Kaplan-Meier survival curves of these factors. Patients with dense infiltration of "T-zone histiocytes" survived significantly longer than those with less infiltration (P less than 0.05). Cox's proportional hazard general linear model analysis showed the importance of factors, such as lymph node or pleural involvement and the SD of nuclear area, when the pathologic stage was excluded, and of the mitotic index when all four factors were excluded to emphasize the cellular characteristics. It is possible to predict the postoperative prognosis of patients with small pulmonary adenocarcinoma more precisely by combination of the above histopathologic factors.

Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma

“…The precise mechanism underlying the worse OS with the T/T genotype being associated with p53 status remains unknown [32]. However, tumors of MDM2 T/T patients tended to be positive in LVI and pleural invasion (Table 3), which have been reported to be worse prognostic factors associated with tumor proliferation and aggressiveness [33,34]. These results indicate that the tumors of T/T patients in the stage I period might have overall malignant potential, although p53 tumor suppressor function is normal.…”

Ets-1 Proto-Oncogene as a Potential Predictor for Poor Prognosis of Lung Adenocarcinoma

“…The prognosis of lung cancer correlates with histopathological type and differentiation (Takise et al 1988). The development and progression of carcinoma is thought to follow a series pathological type, clinical features and patient prognosis after resection.…”

Prognostic factors in resectable pathological N2 disease of non-small cell lung cancer

“…Previous studies had reported that several pathological factors were related to survival rate; these factors include visceral pleural invasion, [19][20][21][22] vascular invasion, [23] perineural invasion, [24][25][26] histologic grade, [27] and nuclear atypia. [28] Our multivariate analysis indicated that only perineural invasion had a significant effect on disease-free and overall survival rates among N2 NSCLC patients. Perineural invasion was defined as cancer cell spreading to the space surrounding a nerve and was confirmed by the pathologist.…”