Histopathological analysis and clinical correlation of drug reaction with eosinophilia and systemic symptoms (DRESS)

Chi, Ming-Hui; Hui, Rosaline Chung‐Yee; Yang, Chao-Ping; Lin, Jing; Lin, Yi‐Ting; Ho, Hung‐Yao; Chung, Wen Hung; Kuo, Tseng‐Tong

doi:10.1111/bjd.12783

Cited by 57 publications

(68 citation statements)

References 13 publications

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“…EBV viral capsid antigen IgG, D early antigen as well as EBV nuclear antigen titres were high in this case suggesting a possible reactivation of virus 20. Histological findings associated with DRESS are variable and not very specific 21. Common themes in the histopathology of DRESS are a dense superficial dermal infiltrate, denser than usual common drug eruptions that may be perivascular or band like, extravasated erythrocytes, dermal oedema and occasionally small granulomas in the superficial dermal infiltrate.…”

Section: Discussionmentioning

confidence: 68%

Drug rash with eosinophilia and systemic symptoms (DRESS) caused by phenytoin

Riaz¹,

Ragsdale²,

Rahman

et al. 2017

BMJ Case Reports

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Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare but potentially life-threatening condition with high mortality. Diagnosis is challenging due to variable clinical presentation and a protracted latency period following initiation of the offending drug. DRESS is a complex interplay that starts by introduction of the offending drug, reactivation of viruses and activation of the immune system. Herpes virus reactivation is considered a diagnostic marker and indicator of illness severity. Prompt recognition and the removal of offending agent remain the key to successful treatment. In cases of severe organ involvement, corticosteroids, immunoglobulins, antiviral and specialist consultation may be helpful. Here we present a case of a 36-year-old African-American male who presented with symptoms mimicking sepsis with an associated skin eruption that was diagnosed as DRESS.

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Section: Discussionmentioning

confidence: 68%

Drug rash with eosinophilia and systemic symptoms (DRESS) caused by phenytoin

Riaz¹,

Ragsdale²,

Rahman

et al. 2017

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…Intriguingly, the expansion of regulatory T-cells has also been associated to HHV-6 reactivation and DRESS syndrome development [14]. The histologic pattern of skin rash in DRESS syndrome usually displays spongiosis, acanthosis and lymphocytic infiltration in the superficial dermis with few eosinophils [15]. Timely recognition of this entity is of utmost importance since it is associated with a significant mortality rate of 10%-30%.…”

Section: Discussionmentioning

confidence: 99%

Atypical DRESS Syndrome Induced by Lenalidomide in Chronic Hemodialysis

Vlachopanos¹,

Kokkona²,

Zerva³

et al. 2016

J Clin Exp Pathol

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“…It is most commonly associated with antiepileptics, allopurinol and sulfonamides 1 5 6 17 18. DRESS syndrome typically presents with fever, followed by a maculopapular rash covering the limbs, trunk and face, lymphadenopathy, haematological abnormalities and multiorgan involvement, with liver involvement being the most common 1 5–7 15 19 20 Table 3. depicts the range of involvement of different body systems.…”

Section: Discussionmentioning

confidence: 99%