Histopathological analysis of central nervous system tumor; an observational study

Abstract

Background: Though the central nervous system tumor comprises ~2% of all the tumors, an overall increase has been observed especially in less developed countries. This increase in the incidence may be due to exposure of population to various risk factors or improved diagnosis with advancement in the ancillary studies. This study aims to provide a single centre histopathological spectrum of this type of tumor.Materials and Methods: A retrospective cross sectional study on a series of cases was performed in the Department of Pathology, Annapurna Neurological Institute & Allied Science , Maitighar , Kathmandu, Nepal from April 2013 to Jan 2016. Data were analyzed using SPSS version 21.0.Results: A total of 221 brain and CNS tumors (125 females and 96 males) were studied. The mean age at diagnosis was 43.77 years. The most common tumor was meningioma(67 cases, 30.3%), followed by astrocytic tumor (57 cases, 25.7%) and pituitary adenoma(30 cases,13.6%). The frequency of WHO grade I, II,III and IV tumor were 94 cases (55%), 34 cases (19.9%),10 cases (5.8%), and 33 cases (19.3%) respectively. The astrocytic tumor was most frequent tumor in children (7/20 caes, 37 %).Conclusion: This study showed the most common CNS tumor to be meningioma followed by astrocytic tumors and pituitary adenoma. The spectrum of CNS tumor in children showed divergent histologic pattern according to the age. In age group 0-10 years embryonal tumors were common whereas ages group of 12-years showed propensity towards astrocytoma as in adults.

Histomorphological spectrum of intracranial space occupying lesions: Experience at tertiary care centre

“…11,12,16 Amongst gliomas, in our study the most common type was glioblastoma (41.1%) followed by astrocytomas (18%). Our findings were concordant with studies by Masoodi et al, Pachori et al, Khonglah et al, Adnan et al, Thambi et al and Kakshapati et al 8,10,11,15,21,24 68.6% of glioblastomas belonged to age group 31-60 years. Masoodi 15 In present study, the most common histologic subtype amongst meningiomas was meningothelial meningioma represented by 25 cases (49.03%) followed by 8 cases of atypical meningioma (15.69%) and 6 cases of transitional meningioma (11.76%).…”

“…Other studies showed variable distribution of histomorphological subtypes of meningioma. 2,6,11,12,19,[24][25][26][27] Meningiomas showed female predominance of 29 cases (57%). Our findings were concordant with studies by Nibhoria et al, Khonglah et al, Adnan et al, Kakshapati et al and Priscilla et al 6,11,15,24,26 In our study, grade I tumours were in majority (41%) followed by grade II and IV tumours which were 24% each and grade III tumours (11%).…”

“…2,6,11,12,19,[24][25][26][27] Meningiomas showed female predominance of 29 cases (57%). Our findings were concordant with studies by Nibhoria et al, Khonglah et al, Adnan et al, Kakshapati et al and Priscilla et al 6,11,15,24,26 In our study, grade I tumours were in majority (41%) followed by grade II and IV tumours which were 24% each and grade III tumours (11%). Similar findings were also observed in studies by Shihora et al, Kakshapati et al, Jat et al, Priscilla et al and Jaiswal et al 12,[24][25][26]28 Out of 300 ICSOLs, the most common non neoplastic ICSOL was abscess (5.3%) closely followed by epidermoid cyst (5%).…”

Histomorphological approach of central nervous system (CNS) tumors: A retrospective study at a tertiary teaching care center

“…In the present study, the common age group affected was 41-50 years, which was like Ghanghoria et al [6] , Mondal et al [9] and Kakshapati et al [12] . In our study meningiomas was the commonest tumor with female preponderance like that of studied by Vimal et al [8] and Thambi et al [11] .…”