1998
DOI: 10.1590/s0100-879x1998001000013
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Histopathological analysis of rat mesentery as a method for evaluating neutrophil migration: differential effects of dexamethasone and pertussis toxin

Abstract: In the present study, histopathological analysis of rat mesentery was used to quantify the effect of two anti-inflammatory agents, dexamethasone (Dex) and pertussis toxin (Ptx), on leukocyte migration. The intravenous injection of Dex (1 mg/kg) and Ptx (1,200 ng) 1 h prior to the intraperitoneal injection of the inflammatory stimuli lipopolysaccharide (LPS) or formyl-methionyl-leucyl-phenylalanine (fMLP) significantly reduced the neutrophil diapedesis (LPS: Ptx = 0.86 ± 0.19 and Dex = 0.35 ± 0.13 vs saline (S)… Show more

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Cited by 3 publications
(2 citation statements)
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“…Moreover, PTx caused an increase in the amount and proportion of neutrophils that adhered to the endothelium. Consistent with our finding in mice, PTx treatment in rats also results in increased leukocyte adhesion to the vessel wall ( 46 ). During rolling, intracellular Ca 2+ stores from the endoplasmic reticulum (ER) are released into the cytoplasm through other receptor pathways.…”
Section: Discussionsupporting
confidence: 91%
“…Moreover, PTx caused an increase in the amount and proportion of neutrophils that adhered to the endothelium. Consistent with our finding in mice, PTx treatment in rats also results in increased leukocyte adhesion to the vessel wall ( 46 ). During rolling, intracellular Ca 2+ stores from the endoplasmic reticulum (ER) are released into the cytoplasm through other receptor pathways.…”
Section: Discussionsupporting
confidence: 91%
“…The total and differential cell counts were performed as described elsewhere. 24,25 The results are reported as the number of leukocytes and neutrophils per milliliters of exsudate.…”
Section: Peritonitismentioning
confidence: 99%