Histopathological and biochemical findings of congenital copper deficiency: are these similar to those of caprine arthritis-encephalitis?

Özkul, İbrahim Ayhan; Alçiğir, Günay; Sepici-Dinçel, Aylin; Yonguc, A. D.; Akcora, A.; Turkaslan, J.

doi:10.4142/jvs.2012.13.1.107

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Ozkul et al. () described congenital copper deficiency in goats – swayback disease. The kids with a twisted carpal joint were identified; the animals walked on their articulus carpii and newborn goats had stiff legs.…”

Section: Assessmentmentioning

confidence: 99%

Revision of the currently authorised maximum copper content in complete feed

2016

EFS2

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The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) reviewed (i) the copper requirements of food-producing and pet animals, (ii) the copper concentration in feed materials and complete feed, (iii) the copper bioavailability, and (iv) the calculated background copper concentration of complete feed. Also considered were (i) the influence of dietary copper on gut microbiota profile and on the bacterial antibiotic resistance in target animals and (ii) the environmental occurrence of bacterial heavy metal tolerance (copper resistance) and resistance to certain antibiotics. The data collected supported the possibility of a reduction in some of the currently authorised maximum contents (CAMC) for total copper in feed. The EFSA Panel developed an algorithm to derive newly proposed maximum contents (NPMC) from the requirement and the native dietary copper content. The NPMC (mg Cu/kg complete feed) comprised of maintained (m), decreased (d) and increased (i) values: 15 for bovine before the start of rumination (m), 30 for other bovine (d), 35 for caprine (i), 15 for ovine (m), 50 for crustacean (m) and 25 for other animal species ((d) for piglets up to 12 weeks, (m) for all other species). The NMPC support health, welfare and economic productivity of target animals, except piglets; performance of weaned piglets would be impacted. The NPMC values would not likely have any consequences on the consumers' intake of copper and are of no concern for the safety of the consumer. The reduction from 170 mg to 25 mg Cu/kg feed piglets would have the capacity to save 1,200 tonnes copper/year being spread in the field and thus, to reduce total copper emissions from farm animal production by about 20%. Thus, the reduction of the CAMC to the NPMC would have a significant impact on the concentrations of copper in the environment of piggeries.

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Section: Assessmentmentioning

confidence: 99%

Revision of the currently authorised maximum copper content in complete feed

2016

EFS2

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“…All of these morphological lesions are suggestive of Cu deficiency and have previously been described in outbreaks of the late form of EA (BANTON et al, 1990;SANTOS et al, 2006;GUEDES et al, 2007;OZKUL et al, 2012;SILVA et al, 2014;OHFUJI, 2015 p. 625-628). As in the present case, the most significant findings were the degeneration of axons and myelin in the cerebellum and motor tracts of the spinal cord (RADOSTITS et al, 2007).…”

Section: Histopathological Studymentioning

confidence: 61%

Outbreak of enzootic ataxia in lambs in the semi-arid state of Pernambuco, Brazil

Filho¹,

Soares²,

Miranda³

et al. 2019

Rev Agr Acad

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Outbreak of enzootic ataxia in lambs in the semi-arid state of Pernambuco, Brazil. Surto de ataxia enzoótica em cordeiros no semiárido do estado de Pernambuco, Brasil. AbstractAn outbreak of delayed enzootic ataxia in lambs in southern in the southern semi-arid state of Pernambuco. Affected lambs (n=18) showed symptoms of ataxia of the hind limbs, as well as difficulty in getting up and inability to walk, with a "dog sitting" posture. Histopathological examination of the spinal cord revealed vacuolization, axonal spheroids and myelin remains phagocytosed by macrophages and demyelination of the white matter. Low serum concentration of copper (6.88 μmol/L) was observed. Serum iron, zinc and molybdenum concentrations were at normal levels for the species. Clinical and laboratory data allowed concluding diagnosis of primary enzootic ataxia. ResumoDescreve-se surto de ataxia enzoótica em cordeiros no semiárido do estado de Pernambuco. Os cordeiros afetados (n=18) apresentaram sintomas de ataxia dos membros posteriores, além de dificuldade de se levantar e incapacidade de andar, com postura de "cão sentado". O exame histopatológico da medula espinhal revelou vacuolização, esferoides axonais e restos de mielina fagocitados por macrófagos e desmielinização da substância branca. Baixa concentração sérica de cobre (6,88 μmol/L) foi observada. Concentrações séricas de ferro, zinco e molibdênio estavam em níveis normais para a espécie. Os dados clínicos e laboratoriais permitiram concluir diagnóstico de ataxia enzoótica primária.

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“…The positive impact of some Cu forms on reducing the incidence of gastrointestinal nematodes was mentioned (Burke et al, 2010;Miller et al, 2011). Authors Ozkul et al (2012) describe relationship between significantly decreased serum Cu levels and the swayback disease in goats. Copper deficiency in goats is also associated with osteoporosis, dwarfism, and anemia (Buck et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Copper metabolism in goat-kid relationship at supplementation of inorganic and organic forms of copper

Páleníková¹,

Hauptmanová²,

Pitropovská³

et al. 2014

CZECH J ANIM SCI

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AbstrACt:The aim of the experiment was to compare the effect of inorganic and organic forms of copper (Cu) supplementation on Cu status of goats and their kids, colostrum and milk composition and quality, and on the Cu concentrations in amniotic fluids and fetal membranes. The experiment involved 22 clinically healthy pregnant goats with similar mean Cu concentration in blood serum. Goats were divided into 3 groups: E1, E2, and C. Basal feed ration differed only in Cu form and concentration in a grain mixture. The goats of experimental groups E1 and E2 received the supplement of Cu sulfate and Cu chelate, respectively. Control group C was without Cu supplementation. Blood samples from goats and kids were collected on the day of parturition (day 0; in kids before colostrum intake) and on days 2, 7, and 21 postpartum. On the same days the kids were weighed. Colostrum or milk samples were collected on days 0, 5, and 30. During delivery, also samples of amniotic fluids and fetal membranes were collected. Both forms of Cu supplementation resulted in higher average concentration of Cu (compared to control group) in blood serum of goats (19.5 ± 1.7 and 18.5 ± 2.5 vs. 15.2 ± 4.4 µmol/l, respectively) and blood serum of kids (6.7 ± 0.8 and 6.0 ± 0.5 vs. 6.0 ± 1.0 µmol/l, respectively). Significant differences in Cu serum concentration on the day of parturition in goats were observed in group E1 compared to control (P < 0.05) and also in kids of group E1 compared to group E2 and control (P < 0.05). The Cu concentration in the blood of kids on the day of parturition was significantly (P < 0.01) lower compared to that in maternal blood. Percentages of Cu concentration in the blood of kids in groups E1, E2, and C were 34, 33, and 39% of that in maternal blood. The results of Cu concentration in blood serum of goats on days 2, 7, and 21 were without significant differences between groups. Significantly higher Cu serum concentrations (P < 0.05) were observed in kids on day 2 in group E1 compared to control group and also on day 21 in group E1 compared to group E2. Colostrum Cu concentration was significantly (P < 0.05) higher in group E1 (10.6 ± 3.3 µmol/l) compared to group E2 (7.1 ± 1.5 µmol/l). There were no significant differences observed in Cu concentration in amniotic fluids and fetal membranes. The kids on both forms of Cu supplementation (on day 0 in group E1 and on days 2, 7, and 21 in group E2) had significantly (P < 0.05) higher average weight than the kids from control group. Our results are suggesting that the inorganic form of Cu (copper sulfate) is more efficient than organic (copper chelate) in influencing the Cu metabolism in goat-kid relationship and that Cu supplementing has a positive effect on the weight of kids.

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Histopathological and biochemical findings of congenital copper deficiency: are these similar to those of caprine arthritis-encephalitis?

Cited by 5 publications

References 10 publications

Revision of the currently authorised maximum copper content in complete feed

Revision of the currently authorised maximum copper content in complete feed

Outbreak of enzootic ataxia in lambs in the semi-arid state of Pernambuco, Brazil

Copper metabolism in goat-kid relationship at supplementation of inorganic and organic forms of copper

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