Histopathological and electron microscopic studies of lymphangiectasia of the small intestine in Behcet's disease

Recurrent Oral Ulceration [Abridged Report]

“…In a similar study of 10 patients with Behcet's disease, one was found to have cceliac disease, the remaining patients having no related intestinal symptoms, normal radiology and jejunal biopsies (Ritchken et al 1977). This differs from Japanese studies (Oshima et al 1963), where 50% of such patients had minor intestinal symptoms, butjejunal biopsies in 15 patients failed to show atrophic villi (Asakura et al 1973).…”

Enfermedad de Behçet y enteropatía perdedora de proteínas secundaria a linfangiectasia intestinal

“…Esto contrasta con lo descrito por Asakura et al 11 en 1978, en donde 4 de los 15 pacientes con linfangiectasia intestinal no presentaban hipoproteinemia sérica. Debido a la coexistencia de hipogammaglobulinemia y linfopenia 6 , las infecciones son frecuentes y pueden aumentar la mortalidad 12 .…”

“…El tratamiento se basa en la reposición de proteínas de alto peso molecular, restricción de grasas, suplementos vitamínicos 16,17 y manejo de la enfermedad de base. La restricción de grasas de cadena corta previene la rotura de los vasos linfáticos 11 . Se ha descrito en la literatura la eficacia de octeotrida, a pesar de que su mecanismo de acción no está esclarecido 18 .…”

Extensive alimentary and genital ulceration, mesenteric cysts, malabsorption, T-lymphocyte depletion and subsequent anaplastic bladder carcinoma

“…Both ulceration of the small bowel and necrotizing oesophagitis have been recorded in Beh9et's syndrome (B0e, Dalgaard and Scott, 1958;Baba et al, 1976). But more typical changes are ulcerative colitis (B0e et al, 1958;Empey, 1972;Smith, Kime and Pitcher, 1973;Baba et al, 1976) and lymphangiectasia (Asakura et al, 1973;Tsuchiya et al, 1976). Atrophic villi were thought not to be a feature of the disease (Asakura et al, 1973).…”