Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study

Gamba, Conrado de Oliveira; Dias, EJ; Ribeiro, Lorena Gabriela Rocha; Campos, Leonardo; Estrela‐Lima, Alessandra; Ferreira, Ênio; Cassali, Geovanni Dantas

doi:10.1016/j.tvjl.2012.08.022

Cited by 23 publications

(44 citation statements)

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“…Tumors subclassified as micropapillary carcinomas were particularly noteworthy in this study. These tumors were associated with lower overall survival compared with other tumors, as described in previous studies 40, 41, 42, 43…”

Section: Discussionsupporting

confidence: 75%

Quantitation of the Regional Lymph Node Metastatic Burden and Prognosis in Malignant Mammary Tumors of Dogs

Araújo

Campos

Ferreira

et al. 2015

Veterinary Internal Medicne

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BackgroundAs in women, regional lymph node status impacts survival in dogs with malignant mammary tumors. However, few studies have evaluated regional lymph node metastases in dogs with malignant mammary gland tumors.ObjectivesTo estimate overall survival based on the assessments of the lymph node status and the morphologic and morphometric features in female dogs with malignant mammary gland tumors.Materials and MethodsIn total, 178 lymph nodes from 97 female dogs were assessed and reviewed, and after confirmation by immunohistochemistry (IHC), 161 lymph nodes were selected for analysis of metastases. Animals were considered metastasis‐free (negative lymph nodes) only after IHC analysis for cytokeratin AE1/AE3. The number of positive lymph nodes, the number of metastatic foci, the maximum diameter and the area of metastasis were analyzed, and estimates of overall survival were made.ResultsDogs with metastasis had lower mean survival than those with metastasis‐free regional lymph nodes, showing a direct relationship between the number of affected lymph nodes and shorter survival. However, histologic analysis of the lymph nodes identified lower survival rates in animals with macrometastases and isolated tumor cells, areas of metastasis >20.11 mm², and metastatic diameters >7.32 mm.ConclusionThe identification of ≥1 lymph nodes positive for metastasis and morphometric characterization of lymphatic metastases indicate the prognostic relevance of lymph nodes status in dogs with mammary tumors.

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Section: Discussionsupporting

confidence: 75%

Quantitation of the Regional Lymph Node Metastatic Burden and Prognosis in Malignant Mammary Tumors of Dogs

Araújo

Campos

Ferreira

et al. 2015

Veterinary Internal Medicne

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“…Here, we explored only the endogenous nuclear localization of EGFR in IMPC. Cassali et al [4, 6] showed that canine IMPC is an important comparative model to the human IMPC counterpart and indicated that the morphological and immunohistochemical features of the canine model is similar to what is observed in humans [4, 6, 12, 14]. The five cases of IMPC evaluated in our study presented poor prognosis, high rates of lymph nodes metastasis, high tumor size and poor overall survival [12-14].…”

Section: Discussionsupporting

confidence: 71%

“…Cassali et al [4, 6] showed that canine IMPC is an important comparative model to the human IMPC counterpart and indicated that the morphological and immunohistochemical features of the canine model is similar to what is observed in humans [4, 6, 12, 14]. The five cases of IMPC evaluated in our study presented poor prognosis, high rates of lymph nodes metastasis, high tumor size and poor overall survival [12-14]. The EGFR is not present within the nucleus or in the INM in CMT, which has better prognosis than other malignant histological types [5, 7].…”

Section: Discussionmentioning

confidence: 99%

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Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Rodrigues

Gamba

Faria

et al. 2016

Pathology - Research and Practice

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The epidermal growth factor receptor (EGFR) has been described in the nucleus of primary tumors. Accumulation of EGFR at the nucleus is linked to DNA synthesis and cell proliferation, but the pathological significance of nuclear EGFR is not completely understood. The aim of this study was to investigate the nuclear localization of EGFR in invasive micropapillary carcinoma (IMPC) that is an aggressive neoplasm of canine mammary gland. Confocal immunofluorescence of formalin and paraffin-embedded tissue was used to access the subcellular localization of EGFR. Our results demonstrated that EGFR co-localizes with the inner nuclear envelope marker, Lamin B1 in IMPC. Furthermore, EGFR was not localized within the nucleus or at the inner nuclear envelope membrane in mammary carcinoma in mixed tumor (CMT) that is associated with a better prognosis than other malignant histological types. This finding could be useful as a predictive biomarker of therapeutic response for IMPC.

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“…Ao ser pesquisado na literatura dados sobre a ocorrência de neoplasias mamárias na fêmea Bichon Frisé, foram encontrados apenas estudos retrospectivos citando a raça dentre outras (BRONDEN et al, 2010;CHU et al, 2011ab;GAMBA et al, 2013;STEVENS, 2014;MALATESTA, 2015;RIBEIRO et al, 2015).…”

Section: Introductionunclassified

Complex Adenocarcinoma of the Mammary Gland in a Bichon Frisé Bitch

Soares

Daneze²,

Salomão

et al. 2018

Nucleus Animal.

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RESUMO:Dentre as neoplasias mamárias de cadelas, os adenocarcinomas possuem incidência de 25 a 50% dos casos. Além de serem localmente invasivos, podendo ser únicos ou múltiplos, ulcerados ou não, possuem amplo potencial metastático para linfonodos regionais e pulmões. O presente trabalho teve como objetivo relatar o caso de uma cadela da raça Bichon Frisé que foi atendida com histórico de aumento de volume bilateral nas glândulas mamárias abdominal caudal e inguinal, com evolução de aproximadamente dois meses, apresentando secreção sanguinolenta em mama abdominal caudal esquerda. A paciente não era esterilizada, se apresentava dispnéica e com hipertermia. No exame clínico notou-se aumento de volume com aspecto em placa única que atingia glândulas abdominais (cranial e caudal) e inguinal esquerda e abdominal caudal e inguinal direita, com aproximadamente 8,0 cm de diâmetro, consistência firme, superfície lisa e ulceração na porção cranial da glândula abdominal caudal esquerda. Após exames complementares, deduziu-se tratar-se de um caso de neoplasia mamária. Devido às condições físicas e clínicas da paciente optou-se pelo tratamento clínico de manutenção para posterior reavaliação. Contudo, como a terapia clínica adotada não foi satisfatória para o controle do quadro clínico da paciente, resultando na evolução das lesões neoplásicas e piora clínica após 50 dias do inicio do tratamento, foi realizada eutanásia. No exame histopatológico foi diagnosticado adenocarcinoma complexo grau II.Palavras-Chave: Bichon frisé. Cadela. Mama. Neoplasia. COMPLEX ADENOCARCINOMA OF THE MAMMARY GLAND IN A BICHON FRISÉ BITCH SUMMARY:Among the bitches breast tumors, adenocarcinomas possess incidence of 25 to 50% of cases. In addition to being locally invasive and can be single or multiple, ulcerated or not, have extensive metastatic potential for regional and lung lymph nodes. This study aimed to report the case of a bitch Bichon Frize breed that has been met with an increase in history of bilateral volume in the abdominal mammary flow and inguinal glands, an increase of about two months, with bloody discharge in abdominal breast left flow. The patient was not sterilized, had dyspnea and hyperthermia. The clinical examination showed an increase in volume with a single plate in aspect reached abdominal glands (cranial and caudal) abdominal and inguinal flow rate and left and right inguinal, approximately 8.0 cm in diameter, firm consistency, smooth surface and ulceration cranial portion of the left caudal abdominal gland. After further examination, it was inferred that this is a case of mammary neoplasia. Due to the physical and clinical conditions of the patient, the clinical treatment of maintenance was chosen for later reevaluation. However, as the adopted medical therapy was not satisfactory for the control of the clinical picture of the patient, resulting in the evolution of neoplastic lesions and clinical deterioration after 50 days of initiation of treatment, the patient was euthanized. In histopathological examination, grade II...

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Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study

Cited by 23 publications

References 31 publications

Quantitation of the Regional Lymph Node Metastatic Burden and Prognosis in Malignant Mammary Tumors of Dogs

Quantitation of the Regional Lymph Node Metastatic Burden and Prognosis in Malignant Mammary Tumors of Dogs

Inner nuclear membrane localization of epidermal growth factor receptor (EGFR) in spontaneous canine model of invasive micropapillary carcinoma of the mammary gland

Complex Adenocarcinoma of the Mammary Gland in a Bichon Frisé Bitch

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